Sentences with phrase «with epigenetic mechanisms»
«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms on human lung cancer cells».
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As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?
With increased understanding of the fundamental mechanism, appropriate DNA methylation including the proper functioning of the epigenetic machinery is highlighted to be essential for embryogenesis and adult health [1]- [3].
In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.
It is already known that various epigenetic mechanisms are associated with cell differentiation.
«But life is changing all the time, and the epigenetic code that controls your DNA is turning out to be the mechanism through which we change along with it.
Another important epigenetic mechanism is that the proteins that are packed together with DNA in the cell nucleus, called histones, can be chemically modified in their tails.
And because epigenetic changes typically occur early in life, it may one day be possible to identify young people at risk for suicide by studying their methylation patterns and then to treat them with drugs that regulate this mechanism, Szyf notes.
In order to identify the cancer stem cells from other cells in the tumor, the research team studied epigenetic mechanisms that distinguish between the least - sorted cells, with endless division properties and a potential to create growth, and the more sorted cells which lack this ability.
The ultimate goal is to precisely understand the mechanisms of checkpoint blockade effectiveness and bring next generation, sustainable immunotherapies to even more patients, perhaps using by using epigenetic drugs in combination with checkpoint blockade to allow epigenetic reprogramming of exhausted T cells into durable and functional memory T cells.
In this webinar, viewers will gain insight into the current status of epigenetics research, with an emphasis on understanding the mechanism and effects of DNA methylation.
«Grape - derived compounds may promote resilience against depression, researchers find: New study used DNA epigenetic mapping to analyze novel inflammatory mechanisms influencing brain circuitry associated with depression.»
FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer types as well.
Project description The PhD student position will be associated with projects concerning environmental toxicology and epigenetic mechanisms.
Such epigenetic mechanisms have already been exploited for diagnosis and treatment; for example, DNA hypomethylation therapy with 5 - azacytidine is approved for MDS and is in clinical trials for some other cancers.
In particular, our research focuses on developmental origins of health and disease with an emphasis on environmental exposures and epigenetic mechanisms (DNA methylation and noncoding RNA).
These methods, combined with quantitative, high - throughput, proteomic and genomic read - outs, will allow us to dissect the complex mechanisms governing chromatin dynamics, histone modifications and epigenetic inheritance.
«This discovery will advance our understanding of stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES cells, and help researchers with the rich source of information to better understand some of the unique features — such as self - renewal and pluripotency — of human embryonic stem cells,» said Ng Huck Hui, Ph.D., senior group leader at GIS and a member of the Singapore team that conducted this research.
Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.
Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...
However, the team also found that a chemical called GSKJ4, which had previously been shown to inhibit DIPG cells, worked synergistically with panobinostat, with the two agents counteracting known mechanisms of epigenetic dysfunction in the DIPG cells.
The causes of the widespread differential expression of non-coding RNAs in malignant compared with normal cells can be explained by the location of these genes in cancer - associated genomic regions, by epigenetic mechanisms and by alterations in the processing machinery.
Landmark research published by City of Hope researchers showed, for the first time, a connection between complex epigenetic mechanisms, blood glucose levels and diabetic complications in patients with metabolic memory.
In his view, new characteristics are generated and passed on via epigenetics, subject to the same mechanisms of evolution as those with a purely genetic origin.
While this concept of epigenetic germline inheritance has long been met with skepticism, evidence in support of this route of information transfer is now overwhelming, and some key mechanisms underlying germline transmission of acquired information are emerging.
She collaborates with her colleagues at the University of Minnesota and University of Wisconsin - Madison on understanding genetic and epigenetic mechanisms in regulation of stress response in maize.
Little research has been performed to understand the specific rules and mechanisms of minimal residual disease, including clonal evolution at the metastatic site, epigenetic programs, interaction with organ defense and immune systems, mechanisms of dormancy and re-awakening, and last but not least, mechanisms of therapy resistance in specific niches.
Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16
Recent advances in epigenetics now provide us with mechanisms that may explain how this occurs.
A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder.
Advances in neuroscience have revealed that the process of brain development is driven by a dynamic interaction between the genome (nature) and the environment (nurture).25 Epigenetic mechanisms like DNA methylation and histone acetylation are able to transduce experiences with the environment into long - lasting, even intergenerational changes in gene expression.26 — 35 So although the inherited genetic program is thought to provide a general blueprint for brain architecture, the environment is able to influence which genes are used, when they are used during the course of development, and where they are used within the developing brain.