Sentences with phrase «with epigenetic modifications»

Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.

Not exact matches

This method allows the scientists to measure very subtle effects with very high confidence, while eliminating the effect of any genetic or epigenetic modifications and cell culture related variations that could occur during the experiment.

But unlike with genetic mutations, we can «undo» bad epigenetic modifications.

«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

In addition to RNA transcripts linked with inflammation and stress, the study examines a series of epigenetic transcripts — RNA sequences that have undergone post-transcriptional modification.

While the technology was used with the goal of attaining very high quality genome assemblies, DOE JGI scientists have now additionally taken advantage of this sequencing platform to explore epigenetic (5mC, 6mA) modifications.

The alteration of gene activity, called epigenetics, might result from modification of RNA molecules that interact with genes; a modification of the packaging that carries DNA; molecular switches attached directly to the DNA itself; or even something to do with the cell's power - stations, the mitochondria, Baugh said.

Gene expression is regulated by epigenetic chemical modifications (including methylation and acetylation) on chromatin — histone proteins tightly associated with DNA.

In this research, the team used Arabidopsis thaliana with mutations in a gene related to DNA methylation, and by confirming the instances of hybrid vigor, they investigated which genes and epigenetic modifications regulating the genes were linked to hybrid vigor.

Last year, a study found thousands of epigenetic modifications to DNA in the sperm of obese men, as well as differing amounts of short pieces of RNA, when compared with lean men's sperm.

Since HIV infection itself alters epigenetic processes in the immune system, the research team wondered whether a distinct DNA methylation profile, a major epigenetic modification where methyl groups are added to DNA, occurs in those with HIV associated - cognitive impairment and whether it exists in distinct immune cell populations from the blood.

Recent studies have expanded the search for genetic links from identifying genes toward epigenetics, the study of factors that control gene expression and looks at chemical modifications of DNA and the proteins associated with it.

So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.

Collaborating with the labs of Salk Professors Joseph Ecker and Alan Saghatelian, the Izpisua Belmonte team performed extensive characterization of the new cells and found rsPSCs showed distinct molecular and metabolic characteristics as well as novel epigenetic signatures — that is, patterns of chemical modifications to DNA that control which genes are turned on or off without changing the DNA sequence.

Epigenetics began as a correlative field in which covalent modifications to DNA or histones, the proteins that help package DNA, were associated with gene expression or silencing.

Plotted together with the DNA methylation from MethylC - seq, the integrated picture of epigenetic modifications was quite striking:

With the genome engineering revolution came epigenome - engineering tools - zinc finger nucleases and TALENs fused to epigenetic modifiers enabled epigenetic modifications at a user - specified locus.

These methods, combined with quantitative, high - throughput, proteomic and genomic read - outs, will allow us to dissect the complex mechanisms governing chromatin dynamics, histone modifications and epigenetic inheritance.

Dr. Loftus» current research integrates the identification of these types of epigenetic modifications that mark the melanocyte regulatory genomic landscape with regulatory protein and transcription factor chromatin - binding domains, thus defining groups of non-coding DNA sequences utilized in the control of melanocyte gene expression.

The discovery of small molecule regulators (activators or inhibitors) of epigenetic modification enzymes provides researchers with pharmacological tools with which to investigate the biological consequences of chromatin modifications.

Epigenetic modifications in bacteria, such as DNA methylation, have been shown to affect gene regulation, thereby generating cells that are isogenic but with distinctly different phenotypes.

Tinkering with gene switches can have a profound effect on how they behave, and labs around the world are now scanning the genome in hopes of identifying epigenetic modifications — sometimes called «marks» or «tags» — that could serve as biomarkers, helping to predict and identify a wide range of conditions.