Sentences with phrase «with epithelial cells»

The small intestine and the stomach are lined with epithelial cells that are connected together by tight junctions similar to the tight junctions in the blood brain barrier (BBB) of the brain.

The gut is lined with epithelial cells that are covered by a layer of mucus and a wide array of microbes.

We also found that several carriage strains had lost their type IV pili and that this loss correlated with reduced tumor necrosis factor alpha (TNF - α) expression when cultured with epithelial cells.

In further tests, he and his colleagues designed a mutated version of the botulism compound, based on the novel crystal structure, in which HA would not bind with the epithelial cell protein E-cadherin.

Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.

«An exciting outcome of this study was the allocation of known and novel specific sensory molecules associated with each epithelial cell type,» said Rogel.

Not exact matches

A piece of Wicht's bedsheet the night she was found dead contained another man's sperm, along with a man's epithelial cells.

The strict definition of celiac disease — positive antibodies to gliadin, intestinal endomysium, and tissue transglutaminase, together with the presence of HLA - DQ2 or HLA - DQ8 genes and an intestinal biopsy that shows at least 20 - 25 CD3 cells per 100 epithelial cells — will account for about 75 - 80 % of all those sensitive to gluten.

A 2012 study found that consuming maltodextrin increased bacterial adhesion to human intestinal epithelial cells and enhanced E. coli adhesion, which is associated with autoimmune disorders and dybiosis in your gut.

This process includes the removal of the milk - producing epithelial cells, whereby the alveolar epithelium undergoes apoptosis and is replaced with adipocytes.

Milk sodium concentration is a marker of tight junction closure between mammary epithelial cells; with the onset of secretory activation (stage II lactogenesis) milk sodium concentrations decrease sharply as potassium concentrations increase [14].

It didn't take her long to decide that she missed lab work; in 1985 she joined IFR with an in - house fellowship, investigating how gut epithelial cells interact with microbes.

«With Rudolph,» Farber says, «the coral DNA got inserted into a gene that is normally expressed in the nasal epithelial cells, the cells of his nose.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

People infected with HIV have few signs of microbial translocation during the first six months of infection as it takes time for the virus to kill off epithelial cells and weaken the gut wall so that bacteria can leak through — so treating them early could be more effective.

She and her group had studied the nature and function of epithelial cells, the gut - lining cells that come into contact with breast milk in nursing infants.

«And those are the types of patients, who potentially would eventually go to the intensive care unit, that we think could be treated early in infection with Accolate or Singulair to prevent infection of these epithelial cells and prevent lethal infection.»

The multinational research group utilized a model system where human retinal pigment epithelial cells were infected with Zika virus strain they isolated earlier from fetal brain [T1].

While the PIV - infected epithelial cells retained their natural elongated, columnar shape, the same cells infected with RSV balled up and puffed out of the airway epithelium, causing the infected cells to accumulate in the lumen of the airway.

Three years after publishing a groundbreaking paper in which she isolated adult retinal pigment epithelial stem cells, Temple is in preclinical trials with rats.

When they delivered this virus into the noses of mice and ferrets, the animals» epithelial cells produced the desired antibodies; they then «challenged» the animals with a range of dangerous influenza viruses that no single vaccine can outwit, including H5N1, which kills both birds and humans, and the H1N1 that caused the infamous 1918 pandemic.

The study, which followed four individuals for a year after they were treated with embryonic stem cell - derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.

He found that red ginseng extract improves the survival of human lung epithelial cells infected with influenza virus.

The scientists have been able to show that the corneal epithelial cells can be cultivated and transplanted onto the eyes of rabbits with experimentally induced blindness to surgically repair the front of the eye.

These structures were further examined by tissue - level and immunohistochemical tools, revealing ducts with «excessive layers» of epithelial cells, potentially pre-cancerous lesions that were «highly proliferative» compared to normal ducts, they add.

HER2 - positive breast cancer, which is associated with poor prognosis, has been traced to an excess of signaling through receptors, or docking ports, called HER2 found on the surface of certain mammary epithelial cells.

Frequently, a virus will infect an epithelial cell, which compared with a nerve cells are «real virus factories,» says Schiffer: They produce massive amounts of virus that can infect other nearby epithelial cells and can presumably also infect sexual partners.

To test their idea for the dry form, Amir Kashani of the University of Southern California in Los Angeles and his colleagues coated 6 by 4 - millimetre slithers of polymer with retinal pigment epithelial cells they had grown, then transplanted these into four people.

Irritated by the main cholera toxin, the intestine will gush fluid, and a person will develop cramping, vomiting, and, most notoriously, diarrhea that rapidly becomes a staggering volume of «rice - water» stool: a watery liquid filled with mucous flakes and epithelial cells.

Gut microbiota that live in the outer regions of the mucus and remain a safe distance from epithelial cells provide a benefit to the host, but Chassaing and Gewirtz hypothesize that microbiota that encroach upon host cells drive chronic inflammation that interferes with the normal action of insulin, promoting type 2 diabetes.

Alix therefore functions as a «molecular bridge» that also determines the polarity of individual epithelial cells, namely the way cells are oriented with respect to one another within the epithelial cell layer.

With the passage of time, patches of retinal pigment epithelial cells may die, resulting in bare spots known as geographic atrophy.

The Bäckhed study found that mice developed problems with the protective mucus layer in the colon after just 3 - 7 days of eating the low - fiber diet: this mucus layer became more penetrable and bacteria encroached upon the epithelial cells of the colon.

When a bacterium with the correct - shaped key — called an adhesin — comes by, it attaches itself to the corresponding epithelial cell.

The human airway is lined with two kinds of epithelial cells — those that possess hairlike fringes called cilia and those that don't.

Interestingly, CD44 + / CD24 − population can be generated by induction of epithelial — mesenchymal transition (EMT) by treating breast epithelial cells with EMT - inducing agents such as TGF - β1 (6).

In a study of 51 patients, researchers used a state - of - the art microfluidic device to capture circulating pancreas epithelial cells in 33 percent of patients with early pancreatic lesions and no clinical diagnosis of cancer.

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.

Researchers captured circulating epithelial cells in 73 percent of patients with cancer.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

MAIT cells are also activated by and kill epithelial cells expressing endogenous levels of MRI after infection with the invasive bacteria Shigella flexneri.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in immunocompromised mice with higher efficiency than their epithelial counterparts [5].

Briefly, single - cell suspensions of C57BL / 6 KO and wild - type lymphocytes, which had undergone a 96 hr in vitro boost with γ - irradiated (3,000 rad) BALB / c stimulator lymphocytes, were added to 96 - well microtiter plates (Corning Inc., Corning, NY) along with 2 × 104 51Cr - labeled BALB / c corneal epithelial or endothelial cells in a total volume of 200 μl / well.

Syto -59-stained C57BL / 6 CD4 + effector cells were cultured with BALB / c corneal epithelial or endothelial cells overnight.

Preliminary data we have now obtained further indicate that in somite cells, the activation of the NOTCH pathway triggers a «signalling module» that couples the initiation of myogenesis with the epithelial - mesenchymal transition (EMT) that allows them to migrate into the growing muscle.

Subsequent single - cell flow cytometric assays linked this shorter G1 phase to the more rapid loading of minichromosome maintenance (MCM) helicase complexes when compared to differentiated cells with longer G1 phases (neural progenitor cells and retinal pigmented epithelial cells).

0 Research ArticleRETINAL DISEASES Human ESC — derived retinal epithelial cell sheets potentiate rescue of photoreceptor cell loss in rats with retinal degeneration Karim Ben M'Barek 1,2,3, Walter Habeler1, 2,3, Alexandra Plancheron1, 2,3,

The membrane is coated with proteins that support 3 - D cell growth and it's seeded with human intestinal epithelial cells (from a cell line originally isolated from a colon cancer).

Interaction of oral bacteria with gingival epithelial cell multilayers.