However it was found that estrogen alone does not have so many drawbacks like the other hormonal therapies, therefore women who have had their uterus removed by hysterectomy are prescribed
with estrogen alone.
(Progesterone is added to hormone therapy to protect the uterus lining from a risk of cancer seen
with estrogen alone.)
Not exact matches
In the Women's Health Initiative — a massive study of 161,808 women over 15 years — there was a decrease in mortality among the women in the 50 - to 59 - year - old group who took
estrogen alone or
with progesterone.
These results, also presented at the 2015 European Cancer Congress (ECC2015, abstract # 5BA) today, which involve the group of 1,626 patients
with a Recurrence Score between 0 and 10, demonstrated that 99.3 percent of node - negative,
estrogen receptor (ER)- positive, human epidermal growth factor receptor 2 (HER2)- negative patients who met accepted guidelines for recommending chemotherapy in addition to hormonal therapy, had no distant recurrence at five years after treatment
with hormonal therapy
alone.
An October 2008 Journal of the National Cancer Institute study of postmenopausal women whod taken hormones actually offered reassuring news, at least for BRCA - 1 carriers: The researchers found that the BRCA - 1 women whod taken
estrogen alone or combined
estrogen and progesterone actually had a decreased risk of breast cancer compared
with those who hadnt had HT.
Total hip bone mineral density was maintained in the HRT
alone group (+0.4 + / - 0.4 %) and increased in the HRT + T group (+ 1.8 + / - 0.5 %).85 (That said, it would be much safer to use a topical delivery form for these hormones; there are serious problems
with taking either
estrogen or testosterone orally.
Metagenics Ostera has been clinically shown in a study of postmenopausal women
with low
estrogen levels to support key markers of bone remodeling, positively influence osteocalcin, and offer more effectiveness than diet and exercise
alone.
Initially, it was prescribed in conjunction
with estrogen, but later used
alone (except in cases of vaginal dryness),
with a program of vitamins, modest calcium supplementation, and dietary advise.
It is crucial to realize that
estrogen therapy, when given
alone without testosterone for someone
with Low T, will lead to a condition called
estrogen dominance that further lowers testosterone blood levels in the body.
Compared
with women who had never used HRT of any kind, those who used
estrogen alone (presumably women who had a hysterectomy) had a significant 1.29-fold higher increased risk of breast cancer.
In a clinical study comparing oral
estrogen alone with oral E&T therapy, E&T therapy significantly increased circulating levels of estradiol and free testosterone compared
with baseline.13, 34 Circulating estradiol levels increased in a similar fashion to women assigned to
estrogen - only therapy, while the increase in free testosterone and the reduction in luteinizing hormone and sex hormone — binding globulin levels were significantly greater among the E&T group compared
with the
estrogen - only group.34
HRT —
with either
estrogen alone or a combination of
estrogen and progestin — was linked to a lower colon cancer risk even when the researchers accounted for the women's age, weight, exercise levels and race.