Sentences with phrase «with expression levels»

After calculating the mean and standard deviation of our datasets, we determined proteins with expression levels below the mean minus the standard deviation as not expressed to discretise the gene expression to an on / off value (see Methods for details).

Further comparative genomic and transcriptomic analyses showed infection severity correlated with the expression levels of certain genes shared by nearly all E. coli, including genes involved in motility and nutrient utilization.

The research confirmed that the stability of apoprotein is directly correlated with expression levels.

Not exact matches

Only with regard to the Oliners» third type, the principled orientation, do we get attention to the level of reflectivity and autonomy exercised by persons choosing rescue activity as an expression of their duty in relation to the demands of equity and justice, or their duty in relation to the imperative to care.

These, then, are the several levels of unity that bind together the diverse topics of the chapters to follow: first, the curriculum of education; second, the major problems of contemporary civilization; third, the values by which education is seen as a moral enterprise; and fourth, a concept of value as devotion to worth rather than to satisfaction of desire, together with an ideal of democracy as the social expression of basic moral commitment.

The pastoral role is concerned with ministry to individuals; the priestly role has to do with the proclamation of the faith and with leadership in the liturgical life of the church; the prophetic role focuses on judging the level of humaneness in the social order and pointing to the changes required if common justice is to be approximated; the kingly role takes up governance and the expression of neighbor love through responsible corporate action.

Additionally, tumors from TRPV1 / KO mice cotreated with capsaicin and TPA exhibited higher COX - 2 expression levels compared with mice treated with TPA alone (Fig. 2C).

In the third trial of the nurse home visitor program, nurse - visited, 6 - month - old infants born to mothers with low psychological resources (i.e., maternal IQ, mental health, and sense of efficacy) displayed fewer aberrant emotional expressions (e.g., low levels of affect and lack of social referencing of mother) associated with child maltreatment.18

During his time at the Pride Agenda he has been actively involved with the passage of dozens of laws, ordinances, regulations and Executive Orders on the state and local level affecting New York's LGBT community, including statewide measures like: the Sexual Orientation Non-Discrimination Act; the Hate Crimes Act of 2000; making the state's 9/11 relief inclusive of same - sex couples; guaranteeing domestic partners hospital visitation, legal authority over a loved one's bodily remains, access to Family Court and medical decision making authority; prohibiting discrimination on the basis of gender identity and expression in state employment; and securing over $ 50 million of funding for LGBT health and human services.

«Emoticons help gauge school happiness level in young children: A simple new questionnaire based on emoticon - style facial expressions could help teachers and others who work with children as young as four to engage them on their happiness and wellbeing levels in the classroom.»

A simple new questionnaire based on emoticon - style facial expressions could help teachers and others who work with children as young as four to engage them on their happiness and wellbeing levels in the classroom.

Furthermore, the levels of Runx2 expression among a larger group of 351 newly diagnosed multiple myeloma patients were significantly higher in patients who had a high risk of early disease - related death, as compared with lower - risk patients.

Elevated miR - 182 expression already is associated with premature aging of the eye and, when MCG scientists mimic premature aging by applying hydrogen peroxide, miR - 182 levels increase.

This research suggests that therapy with an agent that increases levels of Dicer or specific miRNA expression could be beneficial to people with metabolic syndrome.

Borrelli said they observed a remarkable decrease in expression levels of some 2,000 genes in this area, coupled with a widespread increase in modifications of basic DNA proteins called histones — particularly those associated with reduced gene activity.

«There are genes and proteins that are expressed in a cell and their activity, or expression level, changes with time of day,» explained St. John.

In GBM patients, PRMT5 expression levels in tumor were significantly associated with lower overall survival;

Once again, they saw that methylation of a single spot in the serotonin transporter gene was associated with lower levels of serotonin transporter expression in the amygdala.

In addition, researchers will scan the tumors for their RB gene expression to test whether low levels of RB correlate with strong responses to cabazitaxel.

When a strain of mice genetically destined to develop a form of TLR7 - dependent lupus was crossbred with a strain in which TREML4 expression was suppressed, offspring lacking TREML4 were protected from the development of lupus - associated kidney failure and had significantly lower blood levels of inflammatory factors and autoantibodies than did mice expressing TREML4.

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

Interestingly, a variant of the WNT10A gene associated with lower levels of its protein's expression has been linked to a greater likelihood of male pattern baldness, according to a recent genome - wide association study.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Association of a protein biomarker with any given disease process, for example, needs to be assessed in terms of disease - independent, confounding factors that may modulate protein expression levels among different individuals.

Using data from a large public brain tumor database called REMBRANDT, the researchers confirmed that patients with lower levels of SND1 survived longer than those with elevated SND1 expression.

In addition, four tRFs had differential expression patterns after feeding with dengue virus and three had altered levels after treatment with antibiotics, suggesting a role in gut microbiome and vector competence to dengue virus infection.

«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.

In clinical samples of high - grade gliomas from patients, the expression levels of both FOXD1 and ALDH1A3 were inversely correlated with disease progression — gliomas with high levels were more rapidly fatal than were gliomas with low levels.

Thomas and his colleagues began this study by searching for other possible IFITM3 variants that correlated with gene expression, levels of the IFITM3 proteins and were common in flu patients in the U.S..

To investigate, they measured mRNA levels associated with the expression of 23,000 genes in human brain tissue.

Then, using Mayo Clinic's large panel of human pancreatic cancer biopsies, the scientists found that expression levels of Rac1b were significantly associated with the cancer's prognosis.

Identification of a specific learning disability is based on determination of the following Individual with Disabilities Education Improvement Act (IDEA): The child does not achieve commensurate with his / her age and ability levels in one or more of the seven areas (oral expression, listening comprehension, written expression, basic reading skill, reading comprehension, mathematical calculations or mathematical reasoning) when provided with learning experiences appropriate for the child's age and ability levels.

But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high - fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

In combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in these bladder cancer cell lines.

Finally, the researchers showed in tests with mice that their nanoparticle iNOP - 7DS can be delivered effectively to the liver, spleen, and lung; and it suppressed the level of messenger RNA involved in the expression of the ApoB gene.

They also stressed that IL - 6's role in inflammation «extends well beyond the immune system and the kidney, with high levels of expression in atherosclerotic plaques and elevated serum levels being associated with increased coronary artery disease and morbidity from hypertension, left ventricular hypertrophy, and development of insulin resistance.»

Because genes on the Y chromosome often vary slightly in sequence — and even function — from the corresponding genes on the X, males could have slightly different patterns of gene expression throughout the body compared with females, due to not only their hormone levels, but also their entire Y chromosome.

Through analyzing several datasets of prostate cancer cases and patient outcomes, the researchers found that a high level of expression of two genes, TOP2A and EZH2, was associated with early recurrence of prostate cancer and metastatic spread, leading to an increased risk of death.

The SPFES is a tool to measure pain levels based on facial expressions of sheep, and has been shown to recognise pain with high accuracy.

«These findings suggest that focusing on genes with conserved expression levels among primates may be helpful in identifying promising candidates for disease - association studies,» the researchers write.

After analyzing blood samples from 13 exposed and unexposed babies, she found that the expression levels of 11 genes were significantly different in newborns with arsenic - exposed mothers.

Likewise, an analysis tissue samples from patients with lung adenocarcinoma with no or low C / EBPα expression revealed that those with lower levels of BMI1 were more likely to survive, a pattern that has prognostic value, the researchers wrote.

When the team analyzed tissues from 261 patients with NSCLC, they found an inverse correlation between the two molecules; that is, more than 80 percent of patient tissues with low levels of the tumor suppressing C / EBPα were positive for BMI1 expression.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

This experiment uses quantitative PCR to detect the expression level of POSTN in CD34 + / CD31 − pulmonary fibroblasts, CD31 + endothelial cells, and CD45 + immune cells isolated from lungs of mice with macrometastases, which is a replication of the experiment reported in Figure 2H.

Quantitative real - time PCR showing levels of expression of several selected membrane transporters in testes from mice treated with drug at 1.0 mg for 4, 8, or 16 weeks.

When the p27 gene was deleted in mice, GATA3 levels increased along with expression of POU4F3.

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.