Sentences with phrase «with gene annotations»

The goal right now, Yu says, is to help with gene annotation efforts and allow search engines to better pinpoint whether or not current research links a condition to a gene.

Not exact matches

The RNA - guided endonuclease Cas9 is a versatile genome - editing tool with a broad range of applications from therapeutics to functional annotation of genes.

The tags can then be compared to the human genome to find out if they match up with genes discovered by annotation.

In terms of functional groups rather than individual genes, of the 51.4 % Bt genes with COG annotations, those related to carbohydrate transport and metabolism comprised 10 % of the input library.

When they compared the results to the Mouse Genomic Informatics Knockout database they found 123 genes that corresponded with functional annotation of abnormal extraembryonic tissue morphology, 121 associated with embryonic lethality, and 14 with abnormal embryo implantation.

Phenotype data from 449 mutant alleles were acquired, representing 320 unique genes, of which half had no previous functional annotation and data from over 27,000 mice were captured, finding that 83 % of the mutant lines are phenodeviant, with 65 % demonstrating pleiotropy.

In addition, we have generated a high - quality RNA - Seq gene annotation pipeline that is now routinely used in Ensembl annotation and is proving particularly useful for species with very little protein or cDNA evidence.

BioGPS interfaces with the CouchDB instance via the REST - based web services for gene annotation queries and retrieval.

In terms of annotation, 966 new genes were found in the PcyM assembly compared to PcyB, with most of these genes being found in the subtelomeres (see Table 2).

Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes.

We considered genes with at least 5 reads mapping in exons and from all biotypes in the annotation.

This indicates that a comprehensive and experimentally supported annotation effort of the human genome simultaneously highlights regions with striking differences in gene organization to other species and may indicate evolutionary events specific to the human lineage demanding further functional analyses.

Draft genome annotation was transferred from P. vivax P01 using RATT21 (version 1), and supplemented with the output of the Augustus22 gene finder, trained on P. vivax P01 as described in23.

Conclusions We present an accurate and comprehensive annotation of the oil palm genome, focusing on analysis of important categories of genes (GC3 - rich and intronless), as well as those associated with important functions, such as FA biosynthesis and disease resistance.

With the substantial increase in predicted gene number and gene quality obtained with the OGSv2 gene set, it is clear that an updated annotation of infection responsive genes would be valuaWith the substantial increase in predicted gene number and gene quality obtained with the OGSv2 gene set, it is clear that an updated annotation of infection responsive genes would be valuawith the OGSv2 gene set, it is clear that an updated annotation of infection responsive genes would be valuable.

First, we add all antimicrobial peptides identified by a previous computational screen [35], filtered to remove cases where gene models were removed during a subsequent annotation or NCBI gene models could not be associated with OGS 2.0 gene models.

This application uses calculated break points to determine fusion genes based on the latest annotation for genomic sequence information, and where relevant the structural variation (SV) events are annotated with predicted RNA and protein sequences.

While it is not straightforward to directly compare the immune repertoire reported here with previous reports that have used different underlying gene models [15], [34], we do note that our inference about the number and identity of signaling components is consistent with previous annotations [15], [34], while our inference about recognition and effectors tends to reflect greater, albeit still relatively minor, differences.

Click «Phenotype Details» to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.

Establish collaborative «networks» with specialist phenotyping consortia or laboratories, providing standardized secondary phenotyping that enriches the primary dataset, and end - user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

A software tool that functionally annotates genetic variants with gene, region, and filter - based annotations.

An extensive analysis of the whole - genome, including annotation of predicted genes and assignment of functional categories, analysis of chromosomal architecture and the distribution of transposable elements, and comparisons with other genomes, is presented with the publication of the sequences of chromosomes 1, 3, and 5.

Due to the more comprehensive GO term annotation of the mouse genome, we attributed GO terms to rabbit genes based on one - to - one orthology relationships with mouse genes.

We integrate functional genomic datasets with up - to - date gene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematgene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematGene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematgene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematgene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematode.

The annotation pipeline was analogous to the resistance gene pipeline with an amino acid similarity threshold of 95 %.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

The functional annotations of all the clusters with ≥ 10 transcripts, which were obtained using the on GO classification categories of the g: Profiler tool for all the genes in each cluster, are shown in Table 2 (for downregulated genes during ES cell differentiation) and Table 3 (for upregulated genes).

Group of Designs for Ballet and Various Stage Productions, 1940s - 50s, including two mixed - media examples with annotations, attributed to Miles White, one designed for the dancer Gene Carrons; six More...