Sentences with phrase «with gene dosage»

Title: Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus Author: S. Jacquemont et al..

In accordance with the gene dosage, a further reduction of up to 70 % of the wt level was observed in hemizygous XpdTTD / KO cells.

Not exact matches

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

Increased gene dosage has been observed in males with non-syndromic mild to moderate ID with speech delay.