Sentences with phrase «with gene regulation»

CNIO researchers have now discovered how the MCRS1 protein — a protein associated with gene regulation and cell death processes — is capable of activating mTOR, and thus, stimulate cell proliferation.

If these sites happen to be regulatory elements of other genes, noncognate binding not only depletes TF molecules, but could also actively interfere with gene regulation.

In 1993, RIMB had 27 members, 25 of whom were involved with gene regulation and development.

Not exact matches

Using blood samples, the study found that regulation of the oxytocin receptor gene OXTR was associated with development of the condition.

Interestingly, as many as nine of the genes have been previously associated with some vascular disease and four more are known to be involved in the regulation of vascular tone, supporting the importance of blood vessels in migraine attacks.

«The reversible nature of the m6A methylmark adds a new layer to the regulation of gene expression now termed «epitranscriptomics» and warrants further research to establish links with human disease such as cancer,» adds Dr Irmgard Haussmann of Coventry University.

But with smaller parties standing to gain political influence, battles over issues such as the regulation of gene - edited organisms and how to cut greenhouse - gas emissions could grow fiercer.

The Greens want the same strict regulation for organisms that have been gene edited with precision technologies such as CRISPR, as has been put in place for those modified with conventional, less precise techniques.

Rather the opposite was true, the altered epigenetic regulation of the gene was responsible for the development of the fatty liver,» added Sophie Saussenthaler, who shared the first authorship with Baumeier.

«Although we know that ZMYND11 controls RNA polymerase II travel ratio in the gene body, we still don't know how this protein, which does not physically interact with polymerase II, actually achieves this regulation,» Shi said.

Experiments in cells with an inactivated form of Argonaute — which contributes only to the antiviral and not the gene regulation activity of RNAi — confirmed that they were observing an antiviral RNAi response.

Teaming up with her friend Xianlin, they studied GADD45a, a gene involved in cell growth regulation.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

Specifically, Toni Gabaldón's group at the Centre for Genomic Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species.

«He was writing in a time before the molecular revolution, before we had much idea of how genes react with one another and the actual molecular basis of changes in genes and their regulation.»

Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «gene regulation,» the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer.

The quantum machine was also able to generate conclusions that were consistent with a biologist's current understanding of gene regulation.

The «methylome» — a picture of the genome regulation taking place in the truffle, is published in the open access journal Genome Biology and illustrates how the truffle deals with its complex genome's repeating elements and «jumping genes».

«Quantum machine shows promise for biological research: In first quantum machine learning study with biological data, researchers leverage D - Wave to understand gene regulation.»

However, scientists have recently found that gene regulation can also happen in an ongoing fashion through epigenetic processes, with the potential to change behavior throughout a lifetime.

This form of interference with bacterial gene regulation is also of pharmaceutical interest as it is known that pathogenic bacteria can protect themselves against attack by the immune system and the effect of antibiotics by forming biofilms, for instance on the epithelium of the respiratory system.

Four of these potential target genes were significantly down - regulated in the prefrontal cortex of corticosterone - treated rats, and this down - regulation inversely correlated with miR -124-3p levels.

A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the ArGenes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Argenes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.

«Along with previous examples of small RNA exchange between fungi and plants, our results imply that this cross-species gene regulation may be more widespread in other plant - parasite interactions,» said Michael J. Axtell, professor of biology at Penn State and an author of the paper.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

Combined with the right computational approaches, scNMT - seq has the potential to reveal undiscovered mechanisms of gene regulation, both in development and disease.»

Dillman explained that his research team also learned more about gene regulation and the evolution of genomes in general as it compared the five sequences with other nematodes.

To determine whether shifts in the balance of anterior and posterior field occurred during fin - to - limb evolution, Onimaru, postdoctoral researcher currently at Sharpe's lab (CRG), and his colleagues carefully compared the expression, function and regulation of genes involved in anterior - posterior patterning in pectoral fins of catsharks, with those of mice.

The dedicated tailoring enzymes are encoded by genes clustered with the assembly line genes for coordinated regulation.

Among the areas where the researchers have seen intriguing dissimilarities between humans and gorillas are in genes associated with sensory perception, keratin (a skin protein) production, insulin regulation, immunity, reproduction and cell signaling.

Furthermore, if transcriptional regulation of adipose tissue function contributes to adiposity - dependent modulation of insulin sensitivity, blood pressure, and other medically important traits, then the genes that correlate with body mass will be candidates for mediating these responses and warrant further evaluation.

With only a single gene and a toolbox of forward and reverse genetic approaches at hand, C. elegans offers an opportunity to explore the exact role of perlipin - related factors in fat regulation throughout development of many different somatic and germline cells.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio - metabolic and - myopathic diseases.

Exposing S. pistillata to seawater with an elevated calcium concentration resulted in up - regulation of gene expression during the day relative to the night.

The high calcium concentration treatment during the day revealed genes associated with cell junction organization process exhibiting up - regulation (Fig. 4).

With respect to the host's transcriptome, alcohol feeding was associated with down - regulation in gene and protein expression of bactericidal c - type lectins Reg3b and Reg3g in the small intestWith respect to the host's transcriptome, alcohol feeding was associated with down - regulation in gene and protein expression of bactericidal c - type lectins Reg3b and Reg3g in the small intestwith down - regulation in gene and protein expression of bactericidal c - type lectins Reg3b and Reg3g in the small intestine.

This is consistent with work in other systems that showed transcripts from BR biosynthesis genes accumulated following loss of BR due to negative feedback regulation (Bancoş et al., 2002; Tanabe et al., 2005; Tanaka et al., 2005).

We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.

This could be an indication of a controlled expression of genes responsible for calcification during daytime, as evidenced by the up - regulation of genes associated with the cartilage and bone biogenesis process.

Shorter patient survival was generally associated with up - regulation of genes involved in mitosis and cell growth, and down - regulation of genes involved in cellular differentiation.

Using databases created by other labs, the Duke University scientists cross-checked areas of human DNA that had developed differences from chimp DNA with areas of DNA they expected to be important for gene regulation.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

We also identify genes involved in electrolyte metabolism and homeostasis, including NR3C2, SCPEP1, WNK2, and CACNA1D, with important direct (47, 48) and indirect (49) physiological consequences for blood pressure regulation.

But more importantly this old study (by mitochondrial membrande phospholipid fatty acids composition remodeling towards a low perodizable index PI and double bond unsaturation index DBI by genetically reduced desaturase (essentially switching perodizable polyunsaturates with monounsaturates / saturates, rendering membranes lipid peroxidation resistant / blocking hydroperoxide formation by DHA n - 3 and lowering mitochondrial DNA lesions formation by membrane lipid peroxidation chain propagation), It's true though that these effects are due to transcriptional lipid genes regulation (so the genes are the reason of this dramatic effect and this is also a gene therapy, that hit the key points) this old study showed

With her recent groundbreaking findings in the field of RNA - mediated regulation based on the CRISPR - Cas9 system, E. Charpentier has laid the foundation for the development of a novel, highly versatile and specific genome editing technology that is revolutionizing life sciences research and could open up whole new opportunities in biomedical gene therapies.

The non-catalytic interactions were enriched for gene regulation with chromatin modification being one of the most striking.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they wrWith increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they wrwith aberrant repetitive genomic sequences,» they write.

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].