Sentences with phrase «with gene sequencing technology»

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Brains of individuals who died with Huntington's, Parkinson's or no neurological condition were analyzed using sequencing technology that provides a data readout of the activity of all genes in the genome.

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

But the benefits of this technology for discerning the circuits of the mind go much deeper, because the virus that carries the photoreceptor genes can also carry promoter sequences that express their payload only in neurons with the appropriate molecular address.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.»

With the state - of - the - art DNA sequencing technology used in this study, they will be able to pinpoint the exact mistake in each patient's SS - related genes.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

She said: «Identifying a fault in Complex I, one of the building blocks of mitochondria which is responsible for causing disease combined with our custom gene capture and the latest sequencing technology means we can screen many more genes to diagnose this debilitating disease.

The researchers also hope to use gene sequencing technology to compare the brains of those who have died of Alzheimer's with those of people who died without neurological diseases, in the hope of finding DNA sequences of particular microbes in the diseased brains.

A relatively new technology called exome sequencing has identified a few families with novel mutations in their HD genes.

next - generation DNA sequencing and gene and protein array platforms, which allow researchers to perform more comprehensive molecular analyses of tumors, more quickly and accurately, than was possible with older technology

Broadly speaking, we are interested in understanding how genes affect behaviour, but despite rapid advances in technology for sequencing and engineering genomes, it is still a challenge to associate particular genes with heritable behavioural differences because behaviour is time consuming to measure and difficult to quantify.

More recently, in a joint initiative with the BBMRI - LPC project (Biobanking and Biomolecular Resources Research Infrastructure — Large Prospective Cohorts) and the Wellcome Trust Sanger Institute, the CNAG - CRG launched a call to promote the use of sequencing technologies for the identification of novel causative variants and genes and to molecularly diagnose rare disease patients.

Developed in collaboration with the Laboratory Medicine, Information Technology and Health Science Research departments of Mayo Clinic Geneticist Assistant NGS Interpretative Workbench, is a web - based tool for the control, visualization, interpretation and historical knowledge base of next generation sequencing data targeted at specific genes for the purpose of identifying potentially pathogenic variants associated with specific conditions such as hereditary colon cancer.

The advent of RNA - seq technology, in conjunction with full genome sequencing, provides a method for the unbiased characterization of genes regulated by infection in almost any species that can be manipulated in the laboratory.

Research Focus: I dedicate my time and effort to develop high - throughput sequencing technologies such as single cell transcriptomic, ChIP - Seq, ChIA - PET, and many more... The scientific rational is to understand better and with a different angle, the mechanisms of epigenetic regulation of gene expression in (rare) immune cells, pathologically relevant in many diseases such as asthma, SLE, tuberculosis...

The design and engineering of advanced solid - state nanopore materials could allow for the development of novel gene sequencing technologies that enable single - molecule detection at low cost and high speed with minimal sample preparation and instrumentation.

The researchers used gene - sequencing technology to determine the most common gene alterations associated with the cancers and then used their test to find and extract from the fluid cancer the DNA specific to each cancer.

With the development of novel genomics technologies, such as Next - Generation Sequencing, numerous new mutations and gene expression signatures have been identified, allowing us to better understand the molecular heterogeneity of hematologic diseases and to better stratify and assess risk for cancer patients.

Sequencing data, combined with skilled bioanalytical approaches and an expert team of gene curators, enables clinicians to access the benefits of the latest genomic advances without having to become technology experts themselves.

And we now have the capacity to learn more about our genes than ever before with the various kinds of genome sequencing technologies available today.