Sentences with phrase «with gene transcription»

«Cells can not efficiently repair their DNA, and there are problems with gene transcription and expression, errant cell division and chromosomal instability, among other things.»

However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 — an indication that the risk variant interferes with gene transcription.

Not exact matches

Other therapies might slow gene transcription so cells make less ApoE protein to begin with.

«Perhaps the methylation of the gene can be compared with a dimming switch, which regulates the transcription of the gene and thus the amount of the enzyme formed.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Others have tracked the first few hours of the embryonic development of sea urchins and other organisms with the goal of seeing how various transcription factors alter gene expression over time.

Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated near the gene under their control.

Disease processes often begin with mutations in the transcription factor, or in the DNA they bind to inside the nucleus of cells to regulate the complex interplay of genes needed for a healthy functioning body.

Transcription factors are proteins that interact with DNA to turn genes on or off.

If an engineered organism mates with a wild counterpart, the transcription factors render the offspring unable to survive by activating genes that cause their cells to die.

Unlike most proteins, those with these special domains can actually bind to DNA and act as transcription factors — telling specific genes to turn on or off.

The Rutgers scientists show that the transcription activator protein functions by binding to a specific DNA sequence preceding the target gene and making adhesive, Velcro - like interactions with RNA polymerase that stabilize contacts by RNA polymerase with adjacent DNA sequences.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

The structure defines the interactions that RNA polymerase and the transcription initiation factor sigma make with DNA upstream of a gene.

Researchers have ignored these noncoding RNAs until recently for not complying with the central dogma of biology — that a straight line runs from gene to RNA (transcription) to protein (translation).

In a study described in the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicate.

When a methyl group (a carbon atom with three hydrogen atoms attached) binds to a cytosine molecule (one of the four nucleotides that make up DNA), it tells the cell's transcription machinery not to transcribe that gene.

KLF4 together with other reprogramming transcription factors is used in the lab to force the expression of genes in somatic cells (adult non-germline cells) in the development of iPSCs.

With single - cell RNA sequencing, much more gene transcription was detected than before.

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

The genes for each transcription factor were made from different bits of DNA that code for the functional parts of proteins, such as a domain that can bind to DNA and another that provides the protein with access to the cell's nucleus.

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

«These findings directly contradict the traditional view that the Y is largely heterochromatic with a paucity of genes and transcription activity,» said the researchers, who released their findings in the current online issue of Proceedings of the National Academy of Sciences.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

It is expected that the knowledge of the functions of these transcription factors, when combined with gene editing techniques, will allow for the efficient regeneration of blood vessels.

Researchers at Princeton observed that transcription occurs in bursts in response to a single enhancer acting simultaneously at two genes, one labeled with green dye in the left panel and the other labeled with red dye in the middle panel.

Environmental factors interact with the different subgenomes to modify the transcription of their component genes and to modulate the translation of protein products and their posttranslational modification, yielding changes in protein and cellular function and metabolism, and defining an intermediate phenotype.

Furthermore, GNC and GNL act, at the gene expression level, in an additive manner with the GOLDEN2 - LIKE1 (GLK1) and GLK2 transcription factor genes, which are also important for proper chlorophyll accumulation.

For example, in the case of the protein SIN3A, a regulator of gene transcription, the small molecule that covalently binds to its reactive lysine blocks the protein's function by disrupting SIN3A's interaction with another protein, TGIF1 — an interaction implicated in some invasive breast cancers.

PPARs form heterodimers with the retinoid X receptor (RXR) and regulate transcription of their target genes and gene networks.

Of 17 regulatory variants identified in the two genes with regulatory variant burden, we show that at least six alter transcription factor - DNA binding in human neuroblastoma cells.

Apart from involvement in DNA repair, TRF2, has been reported to interact with β - catenin which is a transcription factor and also a developmental gene [12].

This finding is consistent with the recent discovery with several «eukaryotic» signature genes in these archaeal lineages, including genes encoding proteins such as actin, tubulin, and several proteins involved in transcription and membrane deformation.

A PCR fragment containing full - length env and rev genes was derived from plasma virion - associated RNA from a subject acutely infected with a clade B virus by reverse transcription and nested PCR amplification.

Plakophilin - 3 Catenin Associates with the ETV1 / ER81 Transcription Factor to Positively Modulate Gene Activity.

A PCR fragment containing full - length env and rev genes was derived from plasma virion - associated RNA from a subject infected with a clade B virus by reverse transcription and nested PCR amplification procedures.

The DNA of those genes is folded tightly, and chemicals called methyl groups attach themselves to the genes, preventing the transcription of genetic code that enables the proteins associated with the genes to form.

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].

The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections.

In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription.

The histone proteins are decorated with different marks, which can affect the various activities of the modified DNA such as transcription, gene silencing, imprinting and replication.

Genes within the same TAD interact with each other more than with genes in other TADs, and domains undergoing active transcription occupy different locations in a nucleus than quiet domGenes within the same TAD interact with each other more than with genes in other TADs, and domains undergoing active transcription occupy different locations in a nucleus than quiet domgenes in other TADs, and domains undergoing active transcription occupy different locations in a nucleus than quiet domains.

Working with Nancy Cox, PhD, professor of medicine and human genetics and section chief of genetic medicine at the University of Chicago, Bell discovered mutations in the genes for glucokinase and for three transcription factors that cause an early - onset form of diabetes called maturity - onset diabetes of the young.

However, the authors found no evidence for a role of Setd7 in histone methylation or as a partner of MyoD in MuSCs and instead, they discovered that Setd7 interacted with - catenin and modulated its methylation status to promote nuclear translocation and the transcription of Wnt - responsive myogenic genes.

La Jolla, CA — BRCA - 2, a gene linked with breast and ovarian cancer, cooperates with male sex hormones to enhance its ability to activate transcription of genes, which may suppress...

Activated E2F leading to transcription of several target genes including cyclin E in late G1 phase which form active complex with CDK2 drives progression from G1 to S phase [7].

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.