Sentences with phrase «with gene variants»

Dr. Tove Fall, lead study researcher at the Department of Medical Sciences and the Science for Life Laboratory at Uppsala University commented, «We knew already that obesity and cardiovascular disease often occur together... in this study we found that individuals with gene variants that lead to increased body - mass index also had an increased risk of heart failure and diabetes.»

In this study we found that individuals with gene variants that lead to increased body - mass index (BMI) also had an increased risk of heart failure and diabetes.

In the new study, researchers calculated genetic scores from over 30 genes for more than 3000 children with no family history of type 1 diabetes but with gene variants known to convey type 1 diabetes risk and who participated in the TEDDY prospective cohort study.

Similarly men with these gene variants were three times more likely to be diagnosed with aggressive prostate cancer (Gleason 8 or more).

When the twins were given cognitive tests after sleep deprivation, those with the gene variant did better, making 40 % fewer errors.

People with the gene variant also had 30 per cent lower levels of insulin when fasting — a sign of slower ageing.

They found that people with the gene variant had the highest risk of side effects when they were given a statin called simvastatin, but this risk was much lower when they took pravastatin.

By 12 months of age, infants with this gene variant whose needs were consistently attended to responded to stress just as effectively as did the babies with other versions of the gene.

While the outlook of patients with this gene variant is poor, these studies offer hope for a new treatment strategy for these men, and more studies are needed using next - generation androgen inhibitors, such as abiraterone and enzalutamide.

Fugger says it is unclear how TNF influences MS, but in patients with the gene variant, the TNF - blocking drugs could be providing a double - whammy by suppressing TNF signalling further.

«Men with the gene variant that is linked to aggression may be less able to inhibit their emotional responses»

PEOPLE with a gene variant known to be linked to aggression may have been born with key brain differences that could make them more likely to snap under pressure.

«Estrogen alters memory circuit function in women with gene variant: Hormone - gene interaction may underlie sex / individual differences in mental disorders.»

People with a gene variant that sharply increases the risk of Alzheimer's disease in old age may show memory impairment earlier than thought — sometimes well before their 60th birthday, according to a new study in the New England Journal of Medicine.

The investigators also found that eating one or more fish meals a week was linked to less Alzheimer's damage in the brain, but only among people with a gene variant called apolipoprotein E (APOE).

Some people are born with a gene variant that results in a deficiency of alpha - 1 antitrypsin.

Not exact matches

The company will now be able to sell health risk reports on three variants found on the BRCA1 and BRCA2 genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.

Collaboration based on new findings from the Regeneron Genetics Center ® showing variant in HSD17B13 gene is associated with reduced risk of chronic liver diseases

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n - 6) and (n - 3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

Health matters: A recent study found that women with good nutrition are more likely to have babies born with a cancer - suppressing gene variant

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

Three of the darker - skin gene variants appear to have evolved from variants linked with less pigment.

Fast population growth has littered our genomes with five times as many rare gene variants as would be expected.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

To identify gene variants associated with musical aptitude, Irma Järvelä at the University of Helsinki, Finland, and colleagues analysed the genomes of 767 people assessed for their ability to detect small differences between the pitch and duration of a sound, and musical pattern.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration.

The archaic - like variants are associated with an increase in the activity of the TLR genes and with greater reactivity to pathogens.

The results, still in a preliminary stage, show that patients with a specific variant in the RET gene - a proto - oncogene or cancer driver gene; variant G2071A - could be more sensitive to this drug.

His team found a variant near the gene associated with earlier breast development in girls and, in boys, earlier voice - breaking.

More specifically, those with some variants of this gene will gradually produce less lactase, the enzyme that breaks down lactose, as they age.

Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

Researchers at Karolinska Institutet, and the Sahlgrenska Academy at Gothenburg University in Sweden have identified a gene variant linked to psychotic symptoms and cognitive impairment in people with bipolar disorder.

When the researchers scanned the volunteers» genes, they found that two variants of the gene AVPR1A correlated strongly with musical ability (PLoS One, DOI: 10.1371 / journal.pone.0005534).

«So, a variant of gene with a positive effect on intelligence, has a negative effect on schizophrenia, body mass index or obesity.»

To link, at a molecular level, a gene variant with biochemical changes and clinical symptoms related to a heritable psychiatric disorder, as in this present study, is therefore something of a breakthrough.

The researchers found, for example, that extraversion was associated with variants in the gene WSCD2 and near gene PCDH15; neuroticism was associated with variants on chromosome 8p23.1 and gene L3MBTL2.

We show that Neandertals shared more genetic variants with present - day humans in Eurasia than with present - day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.

Lupski was comparing genes in people with and without the disease in the hope of finding a gene variant unique to the condition.

By collaborating with Konrad Oexle and colleagues from the Institute of Neurogenomics at the Helmholtz Zentrum, München, Germany, the researchers could conclude that the genetic variants in the gene seem to contribute to all three disorders.

They discovered that several genetic variants in the hunter - gatherers were linked to a gene associated with physical performance, which they hypothesise could be part of the physiological adaptation to cold.

The gene variant linked to graying is found only in people with European ancestry, and it has previously been associated with light hair colors.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

An estimated 40 percent of the population has the primary gene variant associated with celiac disease, but only 1 percent of people with these genes go on to develop intestinal inflammation and damage — the hallmarks of the disease — after ingesting gluten.

Because the vast majority of genes are encoded with exactly the same code, this particular code is often referred to as the canonical or standard genetic code, or simply the genetic code, though in fact there are many variant codes; thus, the canonical genetic code is not universal.

Genes involved in mammary gland development and function had variants associated with greater milk production, perhaps indicating that the Scythians milked their horses.

«Our finding from statistical analyses of all genes in the genome that SMCHD1 was the only plausible site of causal variants for arhinia — lack of a nose — was frankly shocking, since prior to our study no patients had ever been reported with both conditions.»

Although individuals with variants in their FTO gene have almost double the risk of obesity compared with those who do not inherit the gene, «having the FTO variant doesn't mean one is destined to be fat.

Not surprisingly, children with the variant gene also had about 4 pounds more body fat.