Sentences with phrase «with genes controlling»

As humans bred dogs to meet their own specifications, the genes controlling disease tagged along into the next generation with the genes controlling desirable characteristics such as dreadlocks and double toes.

An enhancer doesn't have a one - to - one relationship with the gene it controls.

Not exact matches

I'm not gay, nor lesbian, so I can only imagine what it would be like for those who are born with wrong genes, body, etc., to have to live in a world so full of hatred for something they have no control over.

The method identifies gene sets that show evidence for positive selection in comparison with matched controls, and thus highlights genes for further functional studies.

But still most people would tend to agree that a program of controlled eugenics that involved exterminating humans with defective genes is immoral even though it could accelerate evolution an better the species.

We've been hearing about better male birth control for years now, but in recent weeks two new promising options have come to light: RISUG (reversible inhibition of sperm under guidance), being developed by an Indian scientist, Sujoy Guh, and the discovery of a gene, Katnal1, critical for sperm production; if scientists can tweak the gene with a pill, sperm production will be stalled.

With such an undeveloped little brain, they are about as close to their genes as any human will ever get and have little control over their behavior.

A total of 150 women with a history of two or more recurrent miscarriages and 20 fertile control women with no history of pregnancy losses had buccal swabs taken for DNA analyses of 10 gene mutations [factor V G1691A, factor V H1299R (R2), factor V Y1702C, factor II prothrombin G20210A, factor XIII V34L, beta - fibrinogen -455 G > A, PAI - 1 4G / 5G, HPA1 a / b (L33P), MTHFR C677T, MTHFR A1298C].

More than three gene mutations among the 10 genes studied were observed in 68 % of women with recurrent miscarriage and 21 % of controls.

Kevin Esvelt, head of the Sculpting Evolution lab at MIT Media Lab, which is applying for Safe Genes funding in collaboration with eight other research groups, predicts that eventually, perhaps around 15 years from now, an accident will allow a drive with potential to spread globally to escape laboratory controls.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

Trickery is rife in the living world but in plants and most animals such trickery is instinctive - controlled largely by genes with little or no intellectual input.

The absent genes are replaced with ones that control the immune system specificity.

HEALTHY muscle cells exposed to fat can become like cells taken from people with diabetes, with the genes that control fat - burning permanently switched off.

However, last August a team headed by plant ecologist Allison Snow at Ohio State University demonstrated that this same gene might produce some very tough weeds: She found that wild sunflowers crossed with Bt sunflowers produced offspring that suffered significantly less insect - related damage and produced 50 percent more seeds than control plants without the gene.

The protein is now known to interact with and control dozens of different genes and proteins, and it helps regulate the cycle of molecular events by which cells grow and reproduce.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

US pig farms try to control it with vaccines, but these attempts are largely ineffective because the virus evolves too rapidly, changing the surface proteins targeted by the vaccine while keeping its internal genes unchanged.

In both groups, 30 per cent of flies died, with specific defects showing that the silenced genes controlled mainly early - stage development.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

The researchers found differences of up to 25 per cent in methylation of the same gene compared with controls.

With genes that helped them produce higher - quality eggs for a longer period of time, the TGF - β mutants had double the reproductive span as control worms.

By using pairs of sisters who spent differing amounts of time living with their fathers, the study was able to control for inherited genes and environmental conditions, such as socioeconomic status or religious background, to isolate the effects of fathering quality on daughters.

With optogenetics, researchers can implant optical fibres to control genetically modified animals — could gene therapy bring it to humans?

Although the researchers don't know precisely how the chaperone molecule works, the difference was unmistakable: Less than 40 % of cells treated with gene therapy had clumps, compared to 70 % of controls.

The team's next goal is to identify genes that interact with GmHs1 - 1 and understand how they work together to control calcium and possibly other mineral content.

New remote - control technology may offer biologists a powerful way to do this with cells and genes.

Even after the cells were taken out of microgravity for up to 30 generations before being combined with the control strain, they maintained 72 per cent of their adaptive advantage, pointing to permanent mutations in the genes rather than merely a temporary adjustment.

The control mice, with all genes intact, should have lost sight as photo - receptors — the light - sensitive cells in the retina — died.

«Although we know that ZMYND11 controls RNA polymerase II travel ratio in the gene body, we still don't know how this protein, which does not physically interact with polymerase II, actually achieves this regulation,» Shi said.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

With millions and millions of changes possible in genes that control health in any given person, the challenge of discerning which gene changes are likely to cause disease is vast.

This challenge arose from complaints made initially by breast cancer patients who objected to Myriad's monopoly control over the testing and interpretation of risks associated with these cancer genes.

Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated near the gene under their control.

But of 10 control animals in which an irrelevant gene was stimulated instead, only three preferred the partner they had been with before.

While the increase in EPSPS gene copies has created a nonsustainable way of controlling kochia with glyphosate - only programs, Jugulam said this resistance was evolved as the result of continuous use of glyphosate and the lack of herbicide diversity in controlling this weed.

No one is sure which genes are involved in domestication, but they may have something to do with controlling the release of cortisol and testosterone, the hormones involved with fear and competitive behavior, into the bloodstream.

To further identify the role of TAZ, the research team studied breast tissue at different stages of development using two groups of mice: a control group with the TAZ gene and an experimental group of knock - out mice with the TAZ gene deleted.

Compared with controls, fish with only one copy of each gene exhibit hyperactivity, increased propensity for seizures, increased body and head size, and fat content.

Klingelhutz and his team immortalized immature precursor fat cells by adding in two genes from HPV (the virus that causes cervical cancer) along with a gene for part of an enzyme that controls the length of cells» telomeres — the pieces of DNA that protect chromosome tips from deterioration.

Such high levels of genetic variation poise mosquito populations to rapidly evolve in response to our efforts to control them whether that be with insecticides or any other control measure, including gene drive.»

Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.

June - Koo Lee, M.D., of Seoul National University Hospital, Seoul, Republic of Korea, and colleagues performed a meta - analysis of randomized controlled trials that compared first - generation EGFR TKI (erlotinib and gefitinib) treatment with conventional chemotherapy in patients with advanced NSCLC without mutation of the EGFR gene.

In a study described in the January 28 issue of Nature Neuroscience, the Hopkins team describes this new gene control mechanism and how it may contribute to Rett Syndrome, a nervous system disorder affecting mostly girls that causes problems with movement and communication.

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

The control mice, with all genes...

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Now, Shannon Xu, together with Gantz and Bier, employ CRISPR / Cas9 to edit gene regulatory elements in their native genomic environments, revealing new fundamental mechanisms that control gene activity, as described Feb. 6 in eLife.

Humans have thousands of immune system genes, and they interact with one another in complex ways; some, for instance, control others.

Compared with living people, Neandertals and ancient Siberians known as Denisovans had slightly different patterns of DNA methylation — a chemical modification of DNA that doesn't change the information in genes but helps control gene activity.