Sentences with phrase «with genomic studies»

Sarah's recent work links Genome - Wide Association Studies (GWAS) with genomic studies of the pathogen, and investigates the interaction of both host and pathogen genomes in Vietnamese tuberculosis and enteric fever patients.

Not exact matches

But it has been disappointing in that the kind of genetic variation it detects has turned out to explain surprisingly little of the genetic links to most diseases... One issue of debate among researchers is whether, despite the prospect of diminishing returns, to continue with the genomewide studies, which cost many millions of dollars apiece, or switch to a new approach like decoding the entire genomes of individual patients.The unexpected impasse also affects companies that offer personal genomic information and that had assumed they could inform customers of their genetic risk for common diseases, based on researchers» discoveries...

Many took exception with the study's published title: «A female Viking warrior confirmed by genomics.»

This study opens new avenues of research aiming at integrating genomic and epigenomic data together with environmental exposures in order to elucidate the physio - pathological mechanisms underlying asthma and to promote the development of new therapies.

«We found that Amish people with this mutation have defects in fat storage, increased fat in the liver, high triglycerides, low «good» (HDL) cholesterol, insulin resistance and increased risk of developing type 2 diabetes,» says the study's senior author, Coleen M. Damcott, Ph.D., an assistant professor of medicine in the Division of Endocrinology, Diabetes and Nutrition and member of the Program for Personalized and Genomic Medicine at the University of Maryland School of Medicine.

«We now hope to design larger clinical studies to treat patients» tumors harboring these novel genomic aberrations to further explore the precise extent of clinical benefit for patients with primary or advanced cholangiocarcinoma.»

When the researchers took a closer look on the genomic areas pinpointed in the study, they noticed that most of them overlap with known genes.

The study is the culmination of 12 years of collaboration and combines the French team's expertise in cloning and reproductive biology with the U.S. team's expertise in functional genomics.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

Appearing in the journal's February 2015 issue, the study, «Phylogenetic visualization of the spread of H7 influenza A viruses» uses genomic analysis to look at the phylogenetic history of genes that assort with H7 influenza.

The scientists combined phylogenetics — the study of evolutionary relationships between different species, with genomics — the study of how the genome of an organism conditions its biology.

Using genomic analysis to study cancer in dogs can help develop new therapies for humans with cancer, according to a proof - of - concept study led by the National Cancer Institute (NCI) and the Translational Genomics Research Institute (TGen).

The researchers analyzed genomic data with computational tool, based on cutting - edge computational methods, and designed by the Gabaldón group, to study the yeast family tree.

«This basic study will allow more defined research into the genomic variations associated with colon cancer that are in the region where BMP is regulated.»

Google Genomics, for instance, is studying the application of cloud computing to genomics, and Calico has signed a slew of collaborations with companies and academic institutes.

Whereas methodological concerns plagued those early studies, modern genomic techniques combined with the ability to extract DNA from well - preserved fossils are inching scientists ever closer to the elusive question of Fido's origins.

The new study suggests that through Distributive Conjugal Transfer, mycobacteria have found a way to reap the benefits of genomic mixing without the dependence and energy costs associated with sexual reproduction.

Large - scale genomic studies will probably uncover more gene variants associated with increased risk of developing PTSD, says de Quervain, and may provide a better understanding of the molecular mechanisms involved.

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMA.

As a bonus, my job provides me with a fairly unique opportunity to work on a list of books related to the subject area I studied and enjoy, namely microbiology, immunology, and the rapidly expanding areas of bioinformatics and genomics.

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

A chromosome - specific BAC library was used to assemble 82 % of the chromosome into 1036 contigs that were anchored with 1443 molecular markers, providing a major resource for genetic and genomic studies.

A landmark genomic study, with contributors from over two - dozen countries, shows the current problem of antibiotic resistant typhoid is driven by a single clade, family of typhoid bacteria, called H58 that has now spread globally.

Researchers from 16 collaborating study sites compared genomic data from 2,075 people with and 3,342 without Fuchs dystrophy.

In 2010 the Deciphering Developmental Disorders (DDD) study was established to find diagnoses for children with unknown developmental diseases using genomics.

Dr. Jones obtained his Ph.D. in 2003 from the University of Birmingham Institute of Cancer and Genomic Sciences (United Kingdom) under Professor Lawrence Young, studying the use of gene therapy for targeting Epstein - Barr Virus (EBV) proteins with replication - competent adenoviruses to treat EBV - driven malignancies.

And she worked with the CLINSEQ Study, investigating the experiences of patients who were having their exome sequenced and how they responded to receiving genomic information.

Although «genomic rearrangements have been associated with autism for awhile,» finding more of the novel changes is «quite exciting for the field,» says Simon Gregory, an associate professor of medical genetics at Duke University's Center for Human Genetics, who was not involved in the study.

The Deciphering Developmental Disorders (DDD) study aims to find diagnoses for children with as yet unknown developmental diseases, and demonstrate that new genomic technologies can provide improved diagnostic tests.

Results for different genomic partitions, methods, and data types are consistent with or contradict clades in our TENT ExaML, TENT MP - EST *, and exon - only trees and previous studies of morphology (15), DNA - DNA hybridization (24), mitochondrial genes (14), and nuclear genes (17).

The oat crown rust genomics study compared two strains from North Carolina and South Dakota with different virulent profiles which were obtained in 2012 as part of the routine USDA - ARS Rust Surveys.

The South Hills crossbill, potentially a newly discovered species of finch, has evolved over the past 6,000 years with a unique dependence on its food source, the Rocky Mountain lodgepole pine, in a coevolutionary arms race that also changed the tree, according to a genomic study led by Tom Parchman, a biologist at the University of Nevada, Reno.

«For anorexia nervosa, researchers implicate genetic locus on chromosome 12: Powerful genomic study of anorexia nervosa conducted to date to identify the common roots anorexia shares with psychiatric, metabolic traits.»

For the current study, the same researchers teamed up with John Kash and Michael Katze of the University of Washington School of Medicine in Seattle, who study virus infection and host response at the genomic level.

In the proof - of - principle study, Courchesne, first author Tiziano Pramparo, PhD, and colleagues identified blood - based genomic biomarkers that differentiated toddlers with ASD, ranging in age from one to four years old, from a control group of toddlers without ASD.

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high - intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

A new method by researchers from New England Biolabs and New Mexico State University provides plant biologists with a quick and simple approach for separating plant nuclear DNA from organellar DNA for genomic and metagenomic studies.

Moreover, they have re-used large amounts of data from previous genomic studies and analysed them again with new and better methods.

Still, the team's predictions line up well enough with archaeological evidence and previous genomic studies that many scientists suspect the view from mitochondrial DNA's narrow window is largely accurate.

Through genomic studies and genetic experiments in mice, the scientists found that the ignored areas, known as «non-coding» DNA, activate a change in the 3D structure of DNA that brings promoters and enhancers together with stunning accuracy.

Also, a number of large - scale genomics studies have linked variants of the CPEB4 gene with the impairment of fat metabolism.

«To our knowledge, this is the first study to examine the association of genomics with opioid withdrawal in infants and may provide insight into the mechanisms underlying NAS.

Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»

The new study, which was published online today in the journal Molecular Ecology, finds that fungal organisms reduce their core genomic makeup while coalescing with algae to form a lichen partnership, one presumed to be «obligate» (i.e., requiring both partners) but had previously lacked direct genetic verification.

Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.

The answer lies in the fledgling science of nutritional genomics, the study of how our genes interact with the nutrients in the foods we eat.

«Metabolomics is now often used to accompany large genomic cohort studies from biobanks, to correlate genotype and genomic variants with specific phenotypes, to complement nutritional studies monitoring food components or endogenous metabolites, or to support measurements in epidemiology studies,» says Andreas Huhmer, director of proteomics and metabolomics marketing at Thermo Fisher Scientific, headquartered in Waltham, Massachusetts.

Robert Lovich, a U.S. Navy biologist in California and a coauthor of the study, said: «Long - term monitoring of the island fox and new genomic technologies now give us the capacity for proactive management with far greater precision and a better expected outcome for island foxes in general.»