Sentences with phrase «with glial cells»

The bottom - right image depicts the outlines of neurons only, with glial cells removed; the bottom — left cube visualizes all the axons, the parts of neurons that transmit signals.

Not exact matches

Too much stress suppresses glial cell division — and glial cells take care of myelinization at developmental plateaus (myelin is the capstone for a neuron and facilitates communication with other neurons).

Glial cells in the spine may activate when pain - related neurons are firing, dosing both limbs with inflammatory substances that may trigger an excitatory response but that may also be toxic to nerves.

Right: 87 - Year - old Glial cells wither with age, disrupting signal transmission and leading to cognitive decline.

Two kinds of mouse glial brain cells, microglia and astrocytes, making different versions of the APOE protein were grown with brain nerve cells, or neurons, that make disease - causing forms of tau.

The enhanced mice masterfully memorized new objects, swiftly learned to link certain sounds or situations to an unpleasant foot shock, and displayed un-usually savvy maze navigation — signs of mental acuity that surpassed skills exhibited by either typical mice or mice transplanted with glial progenitor cells from their own species.

It turned out that p75 partners with another class of receptors, called the GDNF (glial cell - derived neurotrophic factor) receptor family.

Neuronal cell - glial cell adhesion was inhibited by prior incubation of the neurons with Fab» fragments of antibodies to neuronal membranes.

Eventually he found that if he treated GRP cells with a special signaling molecule, they generated a type of astrocyte called GDA (glial - restricted precursor derived astrocyte).

Kozai's lab is currently working with Franca Cambi, professor of neurology at Pitt, on a project to understand the role of another type of glial cell on brain injury and neuronal activity.

Therefore, it stands to reason that targeting these glial cells (in lieu of or in combination with neurons) may dramatically improve current treatments.»

We know that glial cells malfunction in people with Down's.

Working with rats and mice, Xi and colleagues found that specialized retinal cells called Müller glial cells release IL - 33 in response to retinal injury.

The problem with reactive glial cells is that they often stay at the injury site, forming a glial scar and preventing neurons from growing back into the injured areas,» he explained.

«Within 3 weeks after expression of the NeuroD1 protein, we saw in the microscope that human glial cells were reinventing themselves: they changed their shape from flat sheet - like glial cells into normal - looking neurons with axon and dendritic branches,» Chen said.

The scientists have used supporting cells of the central nervous system, glial cells, to regenerate healthy and functional neurons, shown in green in this image in the brain of a mouse with Alzheimer's disease.

The team discovered that the pain signals from a peripheral injury combined with subsequent morphine treatment worked together to cause a glial cell signaling cascade.

«More importantly, a retrovirus can infect only dividing cells such as reactive glial cells, but it does not affect neurons, which makes it ideal for therapeutic use with minimal side effect on normal brain functions.»

The researchers compared mice with a normal glymphatic system to those with a disabled gene that prevented glial cells from assisting in the fluid flow.

The cover image was created using images of neural rosettes derived from human iPSCs with and without a 15q11.2 microdeletion (round circles) and images of radial glial cells in the developing mouse cortex (thin filaments), and it is inspired by July 4th fireworks.

Watkins» work with glia, for example, has indicated that long - term opioid therapy may have an effect similar to that of chronic inflammation, causing glial cells to release an excess of cytokines that actually reduce the drug's effectiveness in blocking pain.

Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1 - dependent adhesion to the extracellular matrix.

But after five days of treating the injury with opiods, the glial cells triggered a chain reaction, including spinal cord imflammation.

Sweet T, Khalili K, Sawaya BE, Amini S. Identification of a novel protein from glial cells based on its ability to interact with NF - kappaB subunits.

Contrary to mainstream research, our experimental approach steadily provided data that, with time, lead to a diffused awakening of the scientific community: glial cells can potentially play an enormous role in the pathophysiology of the brain.

Interestingly, this influence appears to work both ways — a mild reduction in disease symptoms was seen when HD mice were treated with normal glial cells.

In the healthy brain, stem cell - like glial progenitors can divide, migrate to an injured site, and become mature oligodendrocytes after myelin loss, but, unfortunately, the efficiency of remyelination declines with age.

We now show that astrocytes generated from the same population of human fetal glial precursor cells, by exposure to either bone morphogenetic protein (BMP) or ciliary neurotrophic factor (CNTF), promote widely divergent outcomes with respect to repairing the injured adult spinal cord.

These transplanted cells fused with neurons and glial cells of the recipient mice.

By contrast, when a human suffers a spinal cord injury, the glial cells form scar tissue, which blocks nerves from ever reconnecting with each other.

Toxoplasma is associated with damage to the brain's astrocytes — glial cells that function as an interface between neuronal and non-neuronal tissues.

Transmission electron microscopy with colloidal gold immunocytochemistry showed structural damage in young and aged microvessel endothelium of ApoE4 animals extended to the cytoplasm of perivascular cells, perivascular nerve terminals and hippocampal neurons and glial cells.

Glial cell tumors and pituitary tumors are most common in brachycephalic (dogs with short, broad heads) breeds, while meningiomas are most frequently seen in dolicocephalic (dogs with long narrow skull) breeds.

To further examine the morphology of cells and the localization of protein expression within the retina, immunohistochemical staining of both paraffin and OCT retinal sections was performed with the following antibodies (Table S1): human cone arrestin (for cone photoreceptors), rhodopsin (for rod photoreceptors), RPE65 (for the retinal pigment epithelium, RPE), glial fibrillary acidic protein (GFAP, for astrocytes and Müller cells), glutamine synthetase (for Müller cells) and G0alpha (for ON bipolar cells).