Sentences with phrase «with hematopoietic»

Today, this study presents tangible progress for patients with a devastating genetic brain disease and opens the door for application to other neurological diseases that are treatable with hematopoietic stem - cell transplantation.

The cell clusters were dismantled and subsequently treated with a hematopoietic differentiation medium.

To study their role in such disorders, we generated knock - in mice with hematopoietic - specific expression of Sf3b1 - K700E, the commonest type of SF3B1 mutation in MDS.

However, after transfecting ES cells with the hematopoietic transcription factor HOXB4, cells can expand stably in vitro and in vivo [9]--[11].

Table 1 details the results of genotypic analysis for the JAK2V617F allele in 607 patients with hematopoietic malignancies.

MSC interact with hematopoietic stem cells (HSC), influencing their homing and differentiation through cell - cell contact and the production of factors and chemokines.

Not exact matches

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

UTSW co-authors include: Co-lead author Maria Winter, a research associate; Dr. Luisella Spiga, a postdoctoral researcher; visiting fellow Lisa Büttner; graduate students Elizabeth Hughes and Caroline Gillis, all of Microbiology; Dr. Breck Duerkop, Instructor, Immunology; Cassie Behrendt, a research technician, Immunology; Dr. Lora Hooper, Professor and Chair of Immunology with appointments in Microbiology and in the Center for the Genetics of Host Defense, a HHMI Investigator and holder of the Jonathan W. Uhr, M.D. Distinguished Chair in Immunology, and the Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Dr. Luis Sifuentes - Dominguez, Instructor of Pediatrics; Dr. Kayci Huff - Hardy, clinical fellow, Internal Medicine in the Division of Digestive and Liver Diseases; Dr. Andrew Koh, Associate Professor of Pediatrics and Microbiology and in the Harold C. Simmons Comprehensive Cancer Center as well as Director of Pediatric Hematopoietic Stem Cell Transplantation at Children's Health; and Dr. Ezra Burstein, Professor of Internal Medicine and Molecular Biology and Chief of the Division of Digestive and Liver Diseases.

Last month she filed a request with the U.S. Food and Drug Administration to offer hematopoietic stem cells to fetuses with α thalassemia, a severe form of the disease that is fatal before or soon after birth.

A transplant of hematopoietic stem cells attempts to cure patients with certain cancers and other serious illnesses that have not responded to conventional chemotherapies.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA - based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

Subsequently, the hematopoietic system has to be replaced with stem cells from the blood of a healthy donor.

Hematopoietic stem cell transplantation (HSCT) is a therapeutic option for many patients with bone marrow failure.

The treatment in the current study, called autologous hematopoietic stem cell transplantation (AHSCT), was given to patients with advanced forms of the disease that had failed to respond to other medications.

In contrast, the safety record of hematopoietic stem cell gene therapy is less clear, with a significant frequency of gene - therapy induced oncogenesis or clonal outgrowth reported in several hematopoietic stem cell trials [56], [57].

Along with the investigational monoclonal antibody, study participants underwent multi-drug chemotherapy, surgery, radiation and autologous hematopoietic stem cell transplantation.

In addition, transgenic autologous hematopoietic stem cells can be successfully transplanted in HIV - infected individuals [18] and several phase I adoptive transfer trials of CD4 + T cells treated with R5 - ZFNs in HIV infected individuals are currently underway.

A Phase 3 Open - Label Randomized Study of Quizartinib (AC220) Monotherapy Versus Salvage Chemotherapy in Subjects with FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidawith FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) ConsolidaWith or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidation

• Subject is refractory to or relapsed after first - line AML therapy (with or without hematopoietic stem cell transplant (HSCT)-RRB-.

Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

This process (see figure) started with spin - embryoid body (spin - EB) formation from cultures of single - cell hiPSC suspensions in 96 well plates, and the subsequent addition of BMP4 and FGF - 2 to induce mesoderm differentiation, and then VEGF and SCF to induce hematopoietic differentiation.

Discussion themes included: - stem cell heterogeneity - stem cell fate decisions - stem cells in regeneration & development - stem cells in disease & treatment - stem cell related bioengineering & biomaterial - theoretical stem cell biology - mathematical modelling with a focus (but no restriction) on neural stem cells, hematopoietic stem cells and diabetes.

Urgent evaluation to help identify optimal hematopoietic stem cell donor for individuals with a hematologic disorder and a family history that raises concerns

In that program, we focused on treating children with both malignant and genetic conditions with generally allogeneic hematopoietic stem cell transplantation.

Hematopoietic stem cell mobilization in patients with multiple myeloma, non-Hodgkin lymphoma or Hodgkin disease

This gave a mixed population of cells with 20 % expressing CD34, a hematopoietic stem cell marker, with some co-expression of endothelial cell markers (CD31, Flk1, and VE - cadherin).

CXCR4 is also involved in the progression of tumor (hematopoietic and solid) via the interaction with SDF - 1.

Isolation and characterization of mesenchymal adult bone marrow stem cells (MSC) and hematopoietic stem cells (HSC) from healthy donors and patients with leukemia.

Hematopoietic stem cell transplantation was also more common in patients treated with inotuzumab ozogamicin (48 % vs 22 %).

Hematopoiesis, where a single hematopoietic stem cell gives rise to the entire blood system, is an important model for differentiation with great medical importance.

Plerixafor in combination with granulocyte - colony stimulating factor (G - CSF) has been approved for hematopoietic stem cell mobilization to the peripheral blood in patients with non-Hodgkin's lymphoma and multiple myeloma [54].

Treating HIV: Although hematopoietic stem cells have been used since World War II to treat victims of radiation, a potential, significant new application was reported just last year: Hematopoietic stem cells were used to successfully treat a patient with HIV, although the procedure is currently risky and much additional research is necessary for it to be widely accephematopoietic stem cells have been used since World War II to treat victims of radiation, a potential, significant new application was reported just last year: Hematopoietic stem cells were used to successfully treat a patient with HIV, although the procedure is currently risky and much additional research is necessary for it to be widely accepHematopoietic stem cells were used to successfully treat a patient with HIV, although the procedure is currently risky and much additional research is necessary for it to be widely accepted and used.

Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. Atkinson

Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor, according to the results of a study published in Lancet Oncology.

Accelerated aging of immune system after hematopoietic stem cell transplantation Researchers demonstrated that hematopoietic stem cell transplantation in patients with hematological malignancies significantly accelerates aging of immune system.

Kim Y - S, Wielgosz M, Hargrove P, Kepes S, Gray J, Persons D, Nienhuis A. Transduction of Human Primitive Repopulating Hematopoietic Cells with Lentiviral Vectors Pseudotyped with Various Envelope Proteins.

For more information, check out our recent webinar with Dr. Suzan Imren on her work with Drs. Colleen Delaney and Guy Sauvageau on ex vivo culture and expansion of normal and leukemic hematopoietic cells.

Generation of an HIV -1-resistant immune system with CD34 (+) hematopoietic stem cells transduced with a triple - combination anti-HIV lentiviral vector.

Hematopoietic stem cells (HSCs) have long been used to provide lifesaving treatments for patients with malignant and non-malignant hematological disorders.

The lab will be focused on the identification of cellular and molecular events regulating hematopoietic cell fate decisions with emphasis on DC development.

We discovered that CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells.

Patients who receive HSCT receive high doses of chemotherapy, with or without radiation, followed by infusion of hematopoietic stem cells (HSCs)-- rare cells that reside within the bone marrow and are capable of producing all varieties of blood cells.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Added to this is the fact that white fat also damages the hematopoietic stem cells of bone marrow which could results in reduced blood cell formation in bone with excess fatty infiltration.

By transplanting Wnt - activated hematopoietic stem and progenitor cells (HSPCs) we demonstrated that Muller cells can be reprogrammed in vivo after fusion with HSPCs.

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).