Sentences with phrase «with high affinity»

A particular challenge, one that could have important therapeutic applications, is to design an antibody that binds with high affinity to a target protein.

Members with a higher affinity will fight more effectively together so it was great to see another tangible benefit to an entirely optional portion of the game.

Objective 2: To generate a plant - derived recombinant, nonanaphylactic, single - chain antibody fragment with high affinity for IgE that can be scaled up for production at kilogram amounts.

A - and S - scores greater than 3 standard deviations over the next listed target are deemed statistically significant and indicate highly specific antibodies with high affinity.

Meanwhile, a weapon with a high affinity stat will have a higher chance to do an extremely damaging critical hit — and in some instances and builds, crits can even be guaranteed in certain situations.

Physiologists have long known that many high - altitude animals have evolved hemoglobins with high affinities for oxygen, which can enhance oxygen uptake in thin air.

Prof. You - Me Kim and her student Dajung Jung at Pohang University of Science and Technology (POSTECH), in collaboration with Prof. Wonhwa Cho's group at the University of Illinois at Chicago, have identified that the majority of human Src homology 2 (SH2) domains not only bind to proteins, but also interact with membrane lipids with high affinity and specificity.

Innova Biosciences FlexLISA kits are designed for the development and optimization of sandwich ELISA assays to detect the presence of any antigen with a high affinity for any antibody pair in complex samples (serum, plasma, urine, and more).

Results showed that 29 patients» scans revealed strong - binding metastases with a high affinity for the imaging agent.

In this study, the researchers demonstrated in a series of in vitro experiments that squalamine, a positively charged molecule with a high affinity for negatively charged membranes, could literally «kick off» α - synuclein from negatively charged membranes, where the protein binds, preventing the formation of the toxic clumps.

Peptides can target the ephrin - binding pocket of Eph receptors with high affinity and specificity, affecting receptor function.

Because each miRNA has multiple target genes, we speculate that the presence of many other target genes with higher affinity to the miR -150-containing RISC will perturb the ability of miR - 150 to regulate the APC mRNA and that miR - 150 has much weaker effect, if any, on the WNT signaling pathway in vivo.

BerkelDon't be too quick in discounting things with negative affinity and don't immediately pick the weapon with the highest affinity either.

2) To generate a plant - derived recombinant, nonanaphylactic, scFv with high affinity for IgE that can be scaled up for production at kilogram amounts.

SIMBADOL is a partial mu agonist with a high affinity and avidity, which allows for a prolonged duration of analgesia.

A - and S - scores greater than 3 standard deviations over the next listed target are deemed statistically significant and indicate highly specific antibodies with high affinity.

This method is directly applicable to sodium, calcium, and other ion channels where inhibitor or modulatory proteins bind with high affinity.

Objective 1: To create a recombinant, nonanaphylactic, single - chain antibody fragment (scFv) with high affinity for canine IgE from the variable region gene sequences of mAb 5.91 clones.

Auxin, says Zheng, acts like «molecular glue» by filling in the gaps in this weak binding and allowing the proteins to bind with high affinity.

A and S scores greater than 3 standard deviations over the next listed target are deemed statistically significant and indicate highly specific antibodies with high affinity.

The observation that the cholera toxin B (CtxB) subunit, a multivalent counter-receptor that binds with high affinity and specificity to GM1 (8), produced the same effects as the Treg product Gal - 1 served to emphasize the pivotal role of GM1 cross-linking in Teff suppression (7).

1) To create a recombinant, non-anaphylactic, single - chain antibody fragment (scFv) with high affinity for canine IgE from the variable region gene sequences of mAb 5.91.