Sentences with phrase «with high disease»

Patients with rheumatoid arthritis, especially with high disease activity, had higher evening levels and a poorer reactivity for laboratory stress.

Access to improved water sources have reduced disease incidence in parts of the world but the use of efficacious vaccines is seen as an important public health tool for countries with a high disease burden.

T gondii is an important zoonosis with a high disease burden in humans.

Not exact matches

Color announced Thursday that it's introducing a Hereditary High Cholesterol Test that can detect a genetic mutation indicating Familial Hypercholesterolemia (FH), a genetic disorder which leaves carriers with high cholesterol that often leads to early heart diseHigh Cholesterol Test that can detect a genetic mutation indicating Familial Hypercholesterolemia (FH), a genetic disorder which leaves carriers with high cholesterol that often leads to early heart disehigh cholesterol that often leads to early heart disease.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Spending on new drugs for those diseases is expected to rise 7 % in 2018, and it's less due to price hikes as it is for the high prices associated with these specialty therapies.

But for most households, high debt is the disease, not the cure, and adding more debt to «stimulate spending» is like trying to put out a fire with gasoline.

Thirty - year - old engineers would have 50 - year - old bodies, complete with potbellies, curved spines and high risks of diabetes and heart disease.

What that means is biotech startups will be able to afford this high - tech equipment, and with it, they'll be able to pinpoint the genetic mutations that cause certain diseases.

It also helps select for survival the strains of the fungus with higher levels of resistance to these chemicals: As the resistant strains become more prevalent, the disease gets harder to control over time.

Average medical spending among people with diabetes is 2.3 times higher than those without the disease.

Just last October, the World Health Organization published a paper concluding that eating processed meats was linked with a higher risk of developing colorectal cancer, a specific type of the disease that begins in the colon or rectum.

Studies have shown that walking more lowers risks of chronic diseases such as high blood pressure, which is linked with decreased cognitive function.

The high price of dealing with the disease reflects not only the cost of medicines but also the management of a range of complications, such as limb amputations and eye problems.

Some recent studies suggest that diets high in fructose are linked with several health problems, including heart disease.

Higher rates of death and cardiovascular disease were seen among those with high sodium intake, defined as higher than 6,000 mg Higher rates of death and cardiovascular disease were seen among those with high sodium intake, defined as higher than 6,000 mg higher than 6,000 mg a day.

Coffee consumption was also consistently associated with significantly lower risk of gallstone disease.25 A non-linear dose response was also apparent, though risk sequentially reduced as consumption increased from two to six cups a day.25 High versus low consumption was associated with a marginally higher risk of gastro - oesophageal reflux disease, but this did not reach significance.64

Mannkind, which focuses on the development and commercialization of inhaled therapeutic products for patients with diseases such as diabetes and pulmonary arterial hypertension, entered a shallow but persistent downtrend in 2004, posting a series of lower highs into 2015.

Minoryx is a clinical stage biotech company leading the development of new therapies for X-linked Adrenoleukodystrophy (X-ALD) and other inborn errors of metabolism, a group of rare diseases of genetic origin with a high unmet medical need.

«Patients with the highest burden of chronic disease typically have the greatest transportation barriers,» he explained.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

In general, companies that are «diseased» but «curable» offer better prospects for high returns than those that are held in favor by everyone with a few dollars to invest.

Maastricht, The Netherlands, 1 November 2017 — Cristal Therapeutics, a clinical stage biopharmaceutical company developing targeted nanomedicines for the treatment of cancer and other diseases with high unmet patient need, announced today that it has begun a Phase 1b...

Chronic sleep deprivation is associated with increased risk of infection, stroke, cancer, high blood pressure, heart disease and infertility.

When women routinely win Nobel Prizes in physics, chemistry or medicine, when a woman becomes a world chess champion, when a woman conceives and develops a brand new computer chip that represents a significant advancement over quad cores, when a woman invents warp drive or phasers, when a woman solves an «insolvable» math problem, when a woman, while working with the Large Hadron Collider, discovers the now - hypothetical Higgs Boson to be an actual scalar subatomic particle, when a woman figures out how to pinpoint the exact location of an electron at any point in time, when a woman working for Merck or Pfizer develops a remedy for Alzheimer's disease, when a woman's baseball team can defeat the New York Yankees, when a woman can bench press six hundred pounds, run the 100 meter dash in under nine seconds or set a world record in the high jump, then the fairer sex will have made an advance or contribution unlike any it has made before.

Apparently your God liked more babies dying but science had a heart and now birth mortality rates are higher than they have ever been in human history with fewer diseases and complications causing baby deaths.

He contends that your religion is akin to a mental disease with a death toll in the high hundreds of millions.

(I'm guessing if I met her she might well be the kind of person who volunteers at a food pantry, runs a business with high ethical standards, sends money each month to an orphanage in Guatemala, and prays regularly for a neighbor stricken with a terminal disease.)

(I say this in spite of the monistic utterances of many mind - cure writers; for these utterances are really inconsistent with their attitude towards disease, and can easily be shown not to be logically involved in the experiences of union with a higher Presence with which they connect themselves.

The great insight about alchoholism is that it is a chronic, incurable disease with a very high rate of relapse.

You are the goddess who guards our boundaries: You protect with you spear; You will protect us from 4408 diseases; You will protect the Harijans from the torture of the High caste.19

I myself will never adopt an understanding that the power to overcome «disease» or sin or «sickness» or whatever alcoholism is, can be received from, or operated with, «something» or «somebody» or a «power greater than myself» or a «higher power» or a «group» or a light bulb, chair, bulldozer, goddess, doorknob, radiator or any of the other «absurd names for God» (as Rev. Sam Shoemaker, our «cofounder» described them).

For those with chronic aches and pains, insomnia, nausea, appetite issues, crohn's disease, and migraines, look for Purple Kush a pure indica strain with a very heavy high.

With all due respect to In»N Out, Chick - Fil - A and Tyson, I don't need you to state your «morals» to know what you stand for — poisoning our country through your disgusting fat foods which makes our citizens obese and leads to a significantly higher risk to many deadly diseases.

Alabama and Mississippi: the most unhealthy region (e.g., the most obese, the most with cardiovascular diseases and etc.), the highest illiteracy rate, the highest teenage pregnancy rates, the most cities ranking in the top 25 most crimes, the most likely to regect scientific facts, the least taxed, the least to be unionized thus the highest proportion of the population in poverty... and of course, the most religious....

More tellingly, no religious category was majority - opposed to prenatal testing and abortion «to avoid a fatal childhood disease,» with evangelicals and traditional Catholics each registering the highest opposition at 46 percent.

He also wrote that gay men are also afflicted with a higher rate of sexually transmitted diseases and mental illness as well.

Studies have shown that individuals with a high concentration of cartenoids in their blood have a decreased risk of cancer and heart disease.

This means you can rest assured that out standards are the highest and our Gluten Free Bread crumbs are safe for a person with Celiac disease, anyone who has chosen to eat gluten free and tastes great so is enjoyed by the entire family.

Pulses, also known as legumes, lentils, and beans are a nutritious way to add high protein, high fiber, and low carbohydrates to a gluten - free diet for people with celiac disease, gluten - intolerence, or wheat allergies.

Packed with high protein, low in fat, and full of fiber, this soup is a complete meal perfect for people with celiac disease, or who have wheat, gluten, and milk allergies.

[1] While oats are a cereal grain with a very high risk of contamination from gluten - containing grains (GCGs), it is now generally accepted that pure oats uncontaminated with GCGs can be safe for persons who have celiac disease.

It does have a high potassium content so patients with kidney disease and on certain medications should check with their doctors before using.

Triglycerides are a form in which fats are carried in the blood, and high triglyceride levels are associated with an increased risk for heart disease, so ensuring you have some monounsaturated fats in your diet by enjoying cashews is a good idea, especially for persons with diabetes.

Insulin promotes the storage of fat, so that when you eat foods with a high GI, you're making way for rapid weight gain and elevated triglyceride levels, both of which have been linked to cardiovascular disease.

In countries with diets high in fibre and wholegrains, diseases such as bowel cancer, diabetes and coronary heart disease are less common.

When I was doing research for my new course (The Endo Toolkit), I found some research that revealed that cortisol levels are significantly higher in women with advanced endometriosis as compared to women without the disease.

By tossing fresh vegetables and legumes into a big pot and letting them simmer, you can nourish your body with healthy nutrients that have been linked to lowering your risk of diabetes, heart disease, cancer, blood pressure and high cholesterol.

In this meta - analysis of 7 studies including more than 150,000 persons, those whose diets provided the highest dietary fiber intake had a 29 % lower risk of cardiovascular disease compared to those with the lowest fiber intake.

Such as it is gluten free, low glycemic, has minimal impact on blood sugar, higher in fiber, healthier baking option for people with inflammation diseases such as diabetes (I am type 1), it is not processed and natural... and SOO many more!