Sentences with phrase «with high expression»

The distributions show that genes with low or no expression (represented in green) tend to have highly methylated promoters, whereas genes with high expression (represented in red) tend to have lower promoter methylation.

Genes with high expression levels are clustered in genomic regions known as ridges.

If the group of patients with high expression of a selected prognostic gene has a higher observed event than expected event, it is an unfavourable prognostic gene; otherwise, it is a favourable prognostic gene.

[14] In RCC, Thompson et al demonstrated that two - thirds of clear cell RCC had PD - L1 expression and those with high expression had worse cancer - specific survival.

For each species, we chose control genes with high expression levels and little sample - to - sample variability.

The team is currently looking into methods to target the STAT3 - PRL - 3 pathway in AML, which could open up new avenues to treat AML patients with high expression of PRL - 3 and offer an attractive anti-leukemia therapeutic strategy.

«We found that the incidence of EMD was significantly higher in patients with high expression of AF1q than those with low expression,» Tse said.

But if Christian theology has the legitimate goal of unraveling the meaning of a «religionless» Christianity, it must take far more seriously than ever before the relationship between Christianity and religion, and this must mean that it is now called to a full encounter with the higher expressions of religion.

Values were normalized to the 0 time point and to tissues with the highest expression levels.

Not exact matches

So we like owning assets with the highest convexity to inflation, with an additional layer of expressions that will benefit from benign moves higher in real rates.

Consistent with that attitude's deepest wisdom, our intellectuals, even of the left - wing, are often employed in «our institutions of higher learning and are permitted relatively free expression because we know that they are really no threat to us.

«What greater expression of faith in the American experiment than this, what greater form of patriotism is there than the belief that America is not yet finished, that we are strong enough to be self - critical, that each successive generation can look upon our imperfections and decide that it is in our power to remake this nation to more closely align with our highest ideals?»

A revealing light can now be cast upon the problem of the distinctive meaning of an apocalyptic faith by comparing that faith — particularly as it is present in the radical Christian — with the higher religious expressions of mysticism.

When a parent or loved one trusts you with their thoughts and decision - making on end - of - life care, it is one of the highest expressions of trust.

Badly written, pretentious and irresponsible in its claims and arguments, wholly lacking in historical sophistication and mastery of its sources, it nevertheless remains our only theological correlation of the original religious ground of Christianity with the higher religious expressions of Oriental mysticism.

Beginning with a Nietzschean analysis of Greek thinking and literature which sees the distancing of the numinous as the center of the Greek experience, this book attempts to demonstrate that the higher expressions of religion in both East and West revolve about an absolute antithesis between religion and reality, wherein religion can only truly and finally realize itself by an absolute negation, dissolution or annihilation of reality itself.

This interpretation fits well with the claim of Ernest Sandeen that fundamentalism should be viewed theologically as a strange coalition between the rising tide of premillennialism that found expression in the prophecy conferences and Bible schools of the late 19th century and the views of Scripture articulated in the high Calvinist theology of.

The Hebrew thinkers, with a penetration that might have spared some later thought its worst blunders, recognized that the meaning of the world can be understood, if at all, only in the light of, and by inclusion of, human life, which is its highest expression.

When sin is defined in terms of sexual purity, the focus of the Christian life shifts away from expression of love for God and neighbor to an obsession with internal conflict between «higher» and «lower» impulses.

Does the faith to which this church is committed deal with a reality that is universal, true and good for all men everywhere and in all time, or is its faith rather the expression of the highest spiritual insights of our particular American culture?

Thou who first wast sensible of and didst first bear witness to that prodigious passion which disdains the dreadful conflict with the rage of the elements and with the powers of creation in order to strive with God; thou who first didst know that highest passion, the holy, pure and humble expression of the divine madness» which the pagans admired — forgive him who would speak in praise of thee, if he does not do it fittingly.

It's not to do with human nature per se; it's to do with sin: envy, jealousy, possessiveness, quarrelling, a lack of willingness to forgive and forget, infidelity, manipulation, the desire to control and dominate, lack of consideration in matters to do with running a home as well as in the bedroom (sex can be one of the highest expressions of love between a man and a woman; it can also be incredibly selfish); hearts that are consistently closed to new life.

Furthermore, the sacrament of marriage itself should hold a high place in the life of the Church since it is the sacramental expression of the relationship between Christ and the Church with a view to the birth of further sons and daughters for the Kingdom of Christ.

Donald R. Griffin (1976, 1984) argues it is high time students of behavior relaxed their behaviorist stance and led the way to an experimental science dealing with the mental expression of animals, and not just of higher animals.

Additionally, tumors from TRPV1 / KO mice cotreated with capsaicin and TPA exhibited higher COX - 2 expression levels compared with mice treated with TPA alone (Fig. 2C).

* I'd say 4 -3-3, because the primary expression of this formation is defensive (i.e., the high press), and they go at that with two bands of three (Accam - de Leeuw - Nikolic, Dax - Juninho - Alvarez)

There was the nation's top ranked high school safety announcing his decision to attend the University of Alabama during the Under Armour All - America Game three weeks ago, while his mom, April Justin, looked on with a pained expression on her face, shaking her head in disapproval of his choice.

Through years of daily artistic expression and an academically challenging curriculum, Waldorf education culminates in the high school grades with a conscious awakening of all the human capacities.

Philips AVENT Double Electric Comfort Breast Pump with 3 expression settings — low, medium, high — in addition to a preset gentle stimulation mode aims to give mothers a pain free and a rewarding breast pumping experience.

«The Illinois Constitution does not require a single store to provide a forum for the exercise of political expression, «contended Donald Mizerk and Renee Goldfarb, top aides to State «s Atty. Jack O`Malley, in written arguments filed with the state high court.

Learn the symptoms so you can tell if your baby is suffering from colic: Crying that is a high pitched, ear - piercing sound; Grimacing or frowning face, with a pained expression; Red, flushed face; Clenched fists; Excessive gas (flatulence, farts, farting a lot, explosive farts or baby farting); Knees drawn up to chest; Baby looks like she or he is in pain; Often worse in the afternoon or evening (but can happen at any time).

At the lectern, Mr. de Blasio told the church's black congregation about the launch of his universal pre-kindergarten plan and signing of a new executive order mandating higher wages at city - subsidized companies — peppering his speech with religious references, criticisms of the stop - and - frisk policing policy and expressions of sympathy for President Barack Obama and his struggles with the Republican - dominated Congress.

As the World marks the international press freedom day, one person who can be used as a model to showcase the state of the observance of the freedom of expression is the senator representing Kogi West Mr. Dino Melaye who was wheeled to the federal high court in Lokoja and slammed with some politically motivated charges of conspiracy to commit crime and other nebulous affiliate charges.

Reduced expression of the protein ANNEXIN - A1 correlated with higher stemness indices in samples of lung adenocarcinoma.

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

Furthermore, the levels of Runx2 expression among a larger group of 351 newly diagnosed multiple myeloma patients were significantly higher in patients who had a high risk of early disease - related death, as compared with lower - risk patients.

They consistently found higher expression of miR - 182 in the different eye tissues they examined from patients with high - tension glaucoma.

Testing human samples, the team documented higher expression of RORα in skin Tregs compared with those in blood, similar to mice.

The researchers found that high expression of the tumor - suppressor ZMYND11 is associated with longer survival for patients with triple - negative breast cancer.

Different abnormalities such as cleft palates, small skulls, and problems with higher brain function were seen depending on which cell types lacked Smc3 expression, but the phenotypes were similar to those seen in CdLS patients.

«We know that in the sacral region, there is a high percentage of sensory neurons with strong p75 expression,» Lee says.

They found that expressions of negative emotions such as anger, stress and fatigue in a county's tweets were associated with higher heart disease risk.

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

«All endpoints of efficacy and tolerability favoured treatment with pembrolizumab, suggesting it should become one standard of care for first line treatment of patients with advanced NSCLC and high PD - L1 expression.

Pembrolizumab is set to become a new option for first line treatment of patients with advanced lung cancer and high PD - L1 expression, according to the results of the phase III KEYNOTE - 024 trial presented at the ESMO 2016 Congress in Copenhagen and published in the New England Journal of Medicine.

Patients with high PRMT5 tumor expression had shorter overall survival (108 days) compared to patients with medium expression (277 days) and low expression (726 days).

KEYNOTE - 024 investigated the efficacy of pembrolizumab compared to standard of care with platinum - based chemotherapy in untreated patients with advanced NSCLC and high PD - L1 expression (defined as expression in at least 50 % of tumour cells).

When the team assessed FAL1 expression in human ovarian cancer samples, they found that high FAL1 expression tended to correlate with poor clinical prognosis.

We identified distinct clusters of CD4 - CTL effector and precursor cells in the TEMRA subset; the precursor cells shared TCR clonotypes with CD4 - CTL effectors and were distinguished by high expression of the interleukin - 7 receptor.

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.