Sentences with phrase «with high expression levels»

Genes with high expression levels are clustered in genomic regions known as ridges.

For each species, we chose control genes with high expression levels and little sample - to - sample variability.

Values were normalized to the 0 time point and to tissues with the highest expression levels.

Not exact matches

Additionally, tumors from TRPV1 / KO mice cotreated with capsaicin and TPA exhibited higher COX - 2 expression levels compared with mice treated with TPA alone (Fig. 2C).

Furthermore, the levels of Runx2 expression among a larger group of 351 newly diagnosed multiple myeloma patients were significantly higher in patients who had a high risk of early disease - related death, as compared with lower - risk patients.

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

In clinical samples of high - grade gliomas from patients, the expression levels of both FOXD1 and ALDH1A3 were inversely correlated with disease progression — gliomas with high levels were more rapidly fatal than were gliomas with low levels.

But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high - fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

They also stressed that IL - 6's role in inflammation «extends well beyond the immune system and the kidney, with high levels of expression in atherosclerotic plaques and elevated serum levels being associated with increased coronary artery disease and morbidity from hypertension, left ventricular hypertrophy, and development of insulin resistance.»

Through analyzing several datasets of prostate cancer cases and patient outcomes, the researchers found that a high level of expression of two genes, TOP2A and EZH2, was associated with early recurrence of prostate cancer and metastatic spread, leading to an increased risk of death.

The SPFES is a tool to measure pain levels based on facial expressions of sheep, and has been shown to recognise pain with high accuracy.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

Dr. Moscat's laboratory, in collaboration with that of Dr. Karin at UCSD, has established for the fist time that p62 is necessary and sufficient for HCC induction in mice and that its high expression level in non-tumor human liver predicts rapid HCC recurrence after curative ablation.

BTHP - 1 parental cells were transduced with the MLV vector MX - DC - SIGN and FACS sorted as a population for high levels of DC - SIGN expression.

Results from studies with human cells showed highly reproducible expression levels, comparable with those determined by high - throughput RNA sequencing (RNA - seq).

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

The high expression levels of two genes (DNMT3A and DNMT3B) related to DNA methylation in our study is also consistent with a mouse study showing the elevated methylation in parthenotes compared to IVF / ICSI embryos [39].

However, when we extracted gene expression levels from the brain transcriptome data following the methodology in Carneiro et al. [29], we found that levels of nucleotide diversity and the proportion of low frequency variants between lowly (bottom 5 %) and highly (top 5 %) expressed genes in our dataset (Table S7) were not significantly different in most comparisons (with the exception of π in O. c. cuniculus) nor did they consistently differ in the expected direction when assuming higher error rates in lowly expressed genes.

In the HepG2 cells, the expression of p53 reached a maximal level with treatment of 10 nM ActD, and decreased with doses of 100 nM or higher for 6 h (Fig. 1B).

Moreover, in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V+S −), and a less differentiated cell type exhibiting a PrEn bias, but with similar regenerative capacities to the Nanog high population (V+S +).

The proposal to nominate Robert - Jan Smits for our inaugural recognition of an individual's Lifetime Achievements for Science and Society is an expression of the high - esteem and reputation he has earned through thick and thin, navigating through often challenging circumstances with a level of professionalism and grace that is second to none».

In contrast, treatment with ActD (10 nM) distinctly induced the expression and phosphorylation of p53 at 3 h, reaching a maximal response at 6 h, and maintaining a high level of p53 for up to 12 h in the HepG2 cells.

In both instances, the ICM state appears to express higher levels of Nanog and this observation is consistent with the heterogeneous expression of Nanog reporter ES cells [8], [12].

In the Hepa - 1c1c7 cells, treatment with ActD (10 nM) distinctly induced the expression and phosphorylation of p53 at 6 h, and a high level of p53 was maintained for up to 12 h (Fig. 1A).

By utilizing paired genome - wide high - throughput DNA sequencing (DNA - seq) with RNA - seq, we found that gene dosage, at the level of individual genes or chromosomal «somy» (a general term covering disomy, trisomy, tetrasomy, etc.), accounted for greater than 85 % of total gene expression variation in genes with a 2-fold or greater change in expression.

This gradient of surface antigen expression was paralleled by a gradient in expression of pluripotency genes, with highest levels of genes like Oct - 4 found in the population of cells with the highest level of antigen expression.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

(B) Liver expression of Apoc3 mRNA levels in mutant mice on a high - fat diet for 6 weeks and treated for the last 5 weeks with control or ApoC - III ASO (n = 3 — 7 / group).

«Our study suggests a therapeutic benefit for repurposing a well - tolerated inhibitor with limited toxicity to treat a specific group of ovarian cancer patients with high levels of CARM1 expression,» said Sergey Karakashev, Ph.D., first author of the study and a postdoctoral researcher in the Zhang Lab.

Genes associated with complex regulatory landscapes generally exhibit high expression levels that remain evolutionarily stable.

Examining expression levels of H2AX in breast cancer tumor data from The Cancer Genome Atlas, a large National Institutes of Health database containing genetic information about tumor tissue from more than 11,000 patients, the Roswell Park team found that breast cancer patients whose tumors had high levels of H2AX had a significantly worse prognosis than those with low levels.

Surprisingly, whether or not a gene's expression was regulated by MeCP2 did not depend on its mCG content; rather, genes with high levels of mCH tended to be most affected by alterations in MeCP2 expression.

In five independent large cohorts in which more than 1100 total patients were followed for overall survival (Desmedt et al., 2007; Esserman et al., 2012; Kao et al., 2011; Pawitan et al., 2005; van de Vijver et al., 2002; Supplementary file 1), high expression level of MELK strongly correlated with increased rates of mortality (all p values < 0.05, hazard ratios > 2)(Figure 2D, Figure 2 — figure supplement 1D).

In multiple independent breast cancer cohorts analyzed, we found a strong association of high expression levels of MELK with a higher grade of malignancy and an unfavorable prognosis regardless of the treatment modality.

The addition of sacha inchi oil slowed down glucose production in 16 (38.1 %) participants that showed a higher concentration of triglycerides before meals (fasting hypertriglyceridemia), whereas an improved expression of sirtuin - 1 (SIRT1), a gene responsible for regulating energy within the cells and coordinating cellular functions, was registered four hours after ingesting the meal enriched with sacha inchi oil, and linked to lowered levels of blood sugar measured at the same time.

With filmmakers such as Coogler and Johnson — alongside Jenkins, Waititi and other creators of handcrafted blockbusters — blazing a trail, hopefully more filmmakers will find a way to satisfy the needs of the system while also building vehicles for personal expression and achievement of craft at the highest levels.

Insights from the three educators» stories reveal how coupling feedback with expressions of high expectations and faith in students» capabilities can influence student motivation, particularly in the level of support felt by students when tackling challenging academic work.

Development of the new CX - 5 aimed to take the emotional appeal and powerful vitality Mazda has pursued with KODO — Soul of Motion design to a yet higher level by creating a fresh expression of beauty that appeals to mature sensibilities.

Grant 1557: High - Resolution Cytogenetic Analysis of Histiocytic Malignancies and Development of a Targeted Assay to Screen for Expression Level Changes Dr. Matthew Breen, PhD Project Goal: The goal of this project is to narrow down the search for genes playing a key role in Histiocytic Malignancies and thus move a step closer to developing targeted therapies for canine patients diagnosed with this devastating cancer.

«We see [the Switch] as a chance to create Pokémon that goes deeper and with a higher level of expression.

But later that year, Ishihara told Bloomenberg the following: «With the Switch, we see it as a chance to create Pokémon that goes deeper and with a higher level of expressWith the Switch, we see it as a chance to create Pokémon that goes deeper and with a higher level of expresswith a higher level of expression.

«With the Switch, «he said,» we see it as a chance to create Pokémon that goes deeper and with a higher level of expressWith the Switch, «he said,» we see it as a chance to create Pokémon that goes deeper and with a higher level of expresswith a higher level of expression.

The posters of Milton Glaser — more than 450 since 1965 — combine conceptual rigour and originality with a mastery of visual language and a high level of artistic expression.

Charles J agreed with Collins J in Livingstone v Adjudication Panel for England [2006] LGR 799 and Sanders v Kingston that whilst the Code satisfies Art 10 it is important that the restraints should not extend beyond what is necessary to maintain proper standards in public life and also that political expression attracts a higher level of protection.

Several investigations found that conduct problems coupled with low levels of CU traits are associated with increased amygdala reactivity to fearful and angry facial expressions (Viding et al., 2012; Hyde et al., 2013; Blair et al., 2014; Sebastian et al., 2014), while those coupled with high levels of CU traits are correlated with decreased amygdala reactivity to emotional stimuli, particularly fearful facial expressions (Odgers et al., 2008; Jones et al., 2009).

The findings from these studies converge to suggest that the mothers of children with high levels of CU traits have a more negative emotion socialization style, characterized by less acceptance and more dismissing of children's experience and expression of emotions.

In contrast, bullying was not associated with the child's perceived problems regulating anger, suggesting that children with higher levels of bullying admit to expressing anger but consider this emotional expression as being under their control.