Sentences with phrase «with high risk factors»

Just like vaccines for other diseases, some cancer vaccines are used preventively, and people with high risk factors, such as strong family history of cancer may use a vaccine to avoid cancer.

Animals with higher risk factors such as Abyssinian cats or English Bulldogs will be more costly to insure than a Manx or a Harrier.

Unless you are one to commute everyday with a high risk factor and an expensive car, we recommend doing the minimum coverage so that you can take care of yourself and those who are less efficient drivers.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

The proclivity to detect and dwell on stressors and threats — a tendency that unites neurotics — explains why the personality trait is not just associated with experiences of fear, moodiness, worry and frustration but also a higher - than - average risk factor for common mental disorders.

Factors that could cause actual results to differ include general business and economic conditions and the state of the solar industry; governmental support for the deployment of solar power; future available supplies of high - purity silicon; demand for end - use products by consumers and inventory levels of such products in the supply chain; changes in demand from significant customers; changes in demand from major markets such as Japan, the U.S., India and China; changes in customer order patterns; changes in product mix; capacity utilization; level of competition; pricing pressure and declines in average selling prices; delays in new product introduction; delays in utility - scale project approval process; delays in utility - scale project construction; delays in the completion of project sales; continued success in technological innovations and delivery of products with the features customers demand; shortage in supply of materials or capacity requirements; availability of financing; exchange rate fluctuations; litigation and other risks as described in the Company's SEC filings, including its annual report on Form 20 - F filed on April 27, 2017.

Factors that could cause actual results to differ include general business and economic conditions and the state of the solar industry; governmental support for the deployment of solar power; future available supplies of high - purity silicon; demand for end - use products by consumers and inventory levels of such products in the supply chain; changes in demand from significant customers; changes in demand from major markets such as Japan, the U.S., India and China; changes in customer order patterns; changes in product mix; capacity utilization; level of competition; pricing pressure and declines in average selling prices; delays in new product introduction; delays in utility - scale project approval process; delays in utility - scale project construction; continued success in technological innovations and delivery of products with the features customers demand; shortage in supply of materials or capacity requirements; availability of financing; exchange rate fluctuations; litigation and other risks as described in the Company's SEC filings, including its annual report on Form 20 - F filed on April 20, 2016.

Factors that could cause actual results to differ include general business and economic conditions and the state of the solar industry; governmental support for the deployment of solar power; future available supplies of high - purity silicon; demand for end - use products by consumers and inventory levels of such products in the supply chain; changes in demand from significant customers; changes in demand from major markets such as Japan, the U.S., India and China; changes in customer order patterns; changes in product mix; capacity utilization; level of competition; pricing pressure and declines in average selling prices; delays in new product introduction; delays in utility - scale project approval process; delays in utility - scale project construction; cancelation of utility - scale feed - in - tariff contracts in Japan; continued success in technological innovations and delivery of products with the features customers demand; shortage in supply of materials or capacity requirements; availability of financing; exchange rate fluctuations; litigation and other risks as described in the Company's SEC filings, including its annual report on Form 20 - F filed on April 27, 2017.

Factors that could cause actual results to differ materially from those expressed or implied in any forward - looking statements include, but are not limited to: changes in consumer discretionary spending; our eCommerce platform not producing the anticipated benefits within the expected time - frame or at all; the streamlining of the Company's vendor base and execution of the Company's new merchandising strategy not producing the anticipated benefits within the expected time - frame or at all; the amount that we invest in strategic transactions and the timing and success of those investments; the integration of strategic acquisitions being more difficult, time - consuming, or costly than expected; inventory turn; changes in the competitive market and competition amongst retailers; changes in consumer demand or shopping patterns and our ability to identify new trends and have the right trending products in our stores and on our website; changes in existing tax, labor and other laws and regulations, including those changing tax rates and imposing new taxes and surcharges; limitations on the availability of attractive retail store sites; omni - channel growth; unauthorized disclosure of sensitive or confidential customer information; risks relating to our private brand offerings and new retail concepts; disruptions with our eCommerce platform, including issues caused by high volumes of users or transactions, or our information systems; factors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled cFactors that could cause actual results to differ materially from those expressed or implied in any forward - looking statements include, but are not limited to: changes in consumer discretionary spending; our eCommerce platform not producing the anticipated benefits within the expected time - frame or at all; the streamlining of the Company's vendor base and execution of the Company's new merchandising strategy not producing the anticipated benefits within the expected time - frame or at all; the amount that we invest in strategic transactions and the timing and success of those investments; the integration of strategic acquisitions being more difficult, time - consuming, or costly than expected; inventory turn; changes in the competitive market and competition amongst retailers; changes in consumer demand or shopping patterns and our ability to identify new trends and have the right trending products in our stores and on our website; changes in existing tax, labor and other laws and regulations, including those changing tax rates and imposing new taxes and surcharges; limitations on the availability of attractive retail store sites; omni - channel growth; unauthorized disclosure of sensitive or confidential customer information; risks relating to our private brand offerings and new retail concepts; disruptions with our eCommerce platform, including issues caused by high volumes of users or transactions, or our information systems; factors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled cfactors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled company.

We'll use smartphones to scan for risk factors of high blood pressure or type - 2 diabetes, «visit» with specialists remotely at medical kiosks — and when we do go for an in - person exam, we'll spend the bulk of time seeing the doctor rather than reading old magazines in the waiting room.

These risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal, state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher - than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets; risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or other intellectual property; a possible impairment in the carrying value of our goodwill or other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.

Equal - weight and volatility - weighted allocations are two common factor allocation frameworks Risk - return ratios are not higher with volatility - weighted allocations Different reasons can explain the superiority of equal - weight allocations INTRODUCTION In July we published a research report «Factors

High - risk loan factors, which are associated with higher mortgage rates, include a history of late or «slow» repayments to creditors; borrowing for a multi-unit home or a condominium; and, borrowing to finance a vacation home or an investment property.

As usual, I don't place too much emphasis on this sort of forecast, but to the extent that I make any comments at all about the outlook for 2006, the bottom line is this: 1) we can't rule out modest potential for stock appreciation, which would require the maintenance or expansion of already high price / peak earnings multiples; 2) we also should recognize an uncomfortably large potential for market losses, particularly given that the current bull market has now outlived the median and average bull, yet at higher valuations than most bulls have achieved, a flat yield curve with rising interest rate pressures, an extended period of internal divergence as measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weakness.

It stands to reason: More gender equality, particularly in corporate settings, likely corresponds with increased productivity; greater innovation; higher employee retention and better risk management — all critical factors for improving a tech company's odds of staying competitive.

Age at marriage may be a risk factor with respect to divorce, but perhaps the more valid conclusion is in the opposite direction, that high divorce rates scare couples away from early marriage.

Moreover, ionized alkaline water can reduce the symptoms associated with diabetes, hypertension, and high cholesterol which are risk factors for heart disease.

In addition, the high fat content of coconut based milk and yogurt exhibit a paradoxical relationship with risks factors for heart disease.

They're going into the second leg at the Etihad with a lead, but the risk factor was sky - high, especially after they nearly lost a three - goal lead against City in January in a match that ended 4 - 3 after two late goals by City.

Documenting how many infants are born with high palates would be a great research project - because a high palate is a risk factor for sleep apnea and possibly SIDS.

The main issues in Australia regarding homebirth centre around the risks to the baby, with higher perinatal mortality rates reported in some studies of homebirth [14, 15] however these studies have included women with risk factors (e.g., twins, medical complications), so it is difficult to draw conclusions about low - risk women [14, 16].

When deciding on the number of embryos to recommend for transfer, we carefully weigh all factors with the goal of offering each patient the highest chance of pregnancy with the lowest possible risk of a high - order multiple gestation (we have this discussion again at the time of embryo transfer).

While most postpartum hemorrhoids are caused by pressure and pushing, several risk factors are associated with a higher risk of postpartum hemorrhoids.

There has been concern raised about a resurgence of vitamin D deficiency and rickets among infants and children, with reports emerging in the United States from Alaska, 1,2 Iowa, 3 Nevada, 4 California, 5 North Carolina, 6 Texas, 7 and mother - infant pairs in Boston, 8 among others.9 The prevalence of vitamin D deficiency in young children also appears to be high in other countries, including England, 10 Greece, 11 and Canada.12, 13 One study from China found a 65.3 % prevalence of vitamin D deficiency among 12 - to 24 - month - olds, but few cases (3.7 %) of radiographic or clinical rickets were noted.14 Previous studies suggest risk factors to be dark skin pigmentation1,3 - 12 and breastfeeding without supplementation.1 - 7, 9,12,13 To date, reports have focused primarily on young infants compared with toddlers.

In fact, if one considered just three factors (maternal education, maternal prenatal alcohol or tobacco, and marital status) one could predict to a high degree postneonatal mortality: children born to unmarried women with lower education and evidence of prenatal drug use had a postneonatal mortality of about 30 per 1000 live births (similar to Ivory Coast); children born to women with none of these risk factors had a postneonatal mortality of about 2 per 1000 live births (similar to Norway); that is, children in this latter category almost never die despite evidence from PRAMS surveys that they are as likely to co-sleep with their parents.

Eighteen women (1.1 %) were expecting twins; 10.2 % of women reported one or more medical or social risk factor during pregnancy (high blood pressure, diabetes, problems with baby's growth, problems with baby's health, depression, lack of social support during pregnancy, or housing difficulties).

The research confirms that a father's emotional engagement — not the amount of time fathers spend with children, rather how they interact with them — leads to multiple positive outcomes, and serves as a significant protective factor against high risk behaviors in both girls and boys.

If you're someone whose chance of successful VBAC is high, and risk of complications is low, based on various factors, and you're in a hospital with access to immediate surgery, then the risks to maternal health are a bit lower with a TOLAC, the rates of neonatal morbidity may even be similar between the two delivery methods.

While father absence has been associated with a host of negative children's outcomes, including increased risk of dropping out of school and lower educational attainment, poorer physical and mental health, and behavioural problems,36 - 40 higher levels of involvement by nonresident fathers may assuage the negative effects of father absence on children's outcomes.41, 42 Quality of the parents» relationship before divorce, or of the pre-divorce father / child relationship, can also be an important factor: children fare worse following divorce when pre-divorce relationships were good and fare better when pre-divorce relationships were poor, 43,44 suggesting children are sometimes better off without a father if the father's relationship to the child or the mother was not good.

First you say that there are only 0.7 % of women with risk factors... then you list all these high risk births you're attending at home.

Which is interesting because both guidelines support induction in the case of GD with high BGLs where the only significant risk factor for birth is a suspected big baby.

Other risk factors include having had gestational diabetes with a previous pregnancy, having a large baby in a previous pregnancy and having consistent high glucose levels prior to pregnancy (usually considered pre-diabetic).

«Children with low levels of vitamin D were more likely to have high blood pressure and lower levels of high - density lipoprotein, also known as good cholesterol — two factors that are considered major risk factors for heart disease later in life «Children with low vitamin - D levels also had higher levels of parathyroid hormone than their counterparts with adequate vitamin D in their blood.

There is clear evidence that the risk of SIDS is associated with the amount of clothing or blankets on an infant and the room temperature.182, 218,294,295 Infants who sleep in the prone position have a higher risk of overheating than do supine sleeping infants.182 It is unclear whether the relationship to overheating is an independent factor or merely a reflection of the increased risk of SIDS and suffocation with blankets and other potentially asphyxiating objects in the sleeping environment.

Some risks factors for pregnancy - related hypertension include being overweight, having hypertension before pregnancy, pregnant with multiples, having a chronic illness, and / or poor diet (high salt and high fat diets).

A bilirubin level of more than 425 μmol / L was chosen to define severe hyperbilirubinemia since an infant with this degree of jaundice is thought to be at high risk of kernicterus.6 Furthermore, the Canadian Paediatric Society recommends considering an exchange transfusion at this level in healthy term infants without risk factors.20

Among newborn characteristics (dimension 4), higher birth weight and lower 1 - min Apgar score were associated with delayed OL; birth weight > 3600 g remained a significant risk factor in a model adjusted for maternal age and BMI.

Another will investigate cases with high - risk young children where other risk factors have been identified.

«We also saw this technology use being associated with more fatigue in the morning, which circling back, is another risk factor for higher BMIs.

Once researchers adjusted for other factors that could affect dementia risk, such as high blood pressure, high cholesterol and smoking, people with high levels of cynical distrust were three times more likely to develop dementia than people with low levels of cynicism.

«Pregnancy - associated melanoma is associated with higher death rates: Study sought to investigate histopathology, staging, risk factors, and outcomes of cutaneous melanoma in women younger than 50.»

Social isolation was associated with a 43 percent higher risk of first time heart attack, when age, sex, and ethnicity were factored in.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Researchers also grouped participants into three groups according to abdominal adipose tissue volume and density change; they found that those with greater increases in fat volume and more decreases in fat density had relatively higher incidence of heart disease risk factors.

Studies have previously shown there is a higher mortality rate due to cancer in people with mental illness, perhaps because of high rates of risk factors such as smoking.

What they found was that a third of the 62 SNPs were associated with traditional risk factors for coronary artery diseases, e.g., high blood pressure or cholesterol values.

The researchers therefore believe that the cognitive problems can be explained to a high degree by the risk factors that are common to patients with different types of heart complaint, for example diabetes, high blood pressure and high cholesterol.

Eligible patients presented with tumor stages of T1c to T3a, prostate - specific androgen (PSA) levels of 20 or below, and one or two of three risk factors: stage T3a, a Gleason tumor score of seven or higher, or a PSA level greater than 10.

The study, the largest of its kind in the world, compared the health of Deaf people with the hearing population and found that Deaf adults have high levels of risk factors for common conditions, such as heart disease, high blood pressure and diabetes.