Sentences with phrase «with hippocampal volumes»

This longitudinal case - control study examines whether hippocampal volume loss occurs during the initial 8 weeks of antipsychotic treatment and whether it is associated with duration of untreated psychosis, and examines molecular biomarkers in association with hippocampal volume loss and duration of untreated psychosis.

Not exact matches

He is planning to conduct a prescribed exercise intervention in a population of healthy older adults with genetic and other risk factors for Alzheimer's disease and to measure the impact on hippocampal volume and brain function.

College football players with and without a history of concussions have less volume in the hippocampal region of the brain that relates to memory and emotion, according to a study published Tuesday by the Journal of the American Medical Association.

College football players with and without a history of concussions have less volume in the hippocampal region of the brain that relates to memory and emotion.

MCI was not associated with total brain volume, hippocampal volume, or cerebral microbleeds.

The investigators also looked for other potential changes, such as hippocampal asymmetry or gene dose - dependent effects on volume, but could find no associations with genetic status.

Lindauer RJL, Vlieger EJ, Jalink M, Olff M, Carlier IVE, Majoie CBLM, den Heeten GJ, Gersons BPR, Effects of psychotherapy on hippocampal volume in out - patients with post-traumatic stress disorder: a MRI investigation.

Lindauer RJL, Olff M, van Meijel EPM, Carlier IVE, Gersons BPR, Cortisol, learning, memory, and attention in relation to smaller hippocampal volume in police officers with posttraumatic stress disorder.

Specifically, individuals diagnosed with major depression have smaller hippocampal and amygdala volumes (34,35), structural and morphological changes in the prefrontal and orbitofrontal cortex (22), and basal ganglia structures (6).

Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30, (2010a): 5368 - 5375.

Researchers have found that BDNF levels decline progressively with age.10 Lommatzsch, M., et al. «The Impact of Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology of Aging 26 (2005):... continue At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... covolume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... coVolume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... continue

Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6 - month randomised controlled trial

Conclusions Aerobic training significantly increased hippocampal volume in older women with probable MCI.

More research is needed to ascertain the relevance of exercise - induced changes in hippocampal volume on memory performance in older adults with MCI.

Results Compared with the BAT group, AT significantly improved left, right and total hippocampal volumes (p ≤ 0.03).

Lower intakes of nutrient - dense foods and higher intakes of unhealthy foods are each independently associated with smaller left hippocampal volume.

Poverty was associated with smaller white and cortical gray matter and hippocampal and amygdala volumes.

These findings extend the substantial body of behavioral data demonstrating the deleterious effects of poverty on child developmental outcomes into the neurodevelopmental domain and are consistent with prior results.8, 9 Furthermore, these study findings extend the available structural neuroimaging data in children exposed to poverty by informing the mechanism of the effects of poverty on hippocampal volumes.

Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16

While animal data would suggest that institutional rearing would lead to reduced hippocampal volume, some investigators have suggested that such effects may not become evident in humans until later in life.18 Consistent with this, decreased hippocampal volumes have been found in numerous studies of adults who experienced high levels of childhood stress / trauma.19, 20 In spite of this hypothesized delayed hippocampal effect, a positive impact of early supportive parenting on hippocampal development has been detected as early as school age.21

Lower socioeconomic status was associated with smaller hippocampal gray matter volumes bilaterally in a small sample of healthy 10 - year - old children.10

Specifically, exposure to prenatal and / or postnatal stress is associated with increased basal and stress - induced responsiveness of the hypothalamic pituitary adrenal axis, increased central corticotropin - releasing hormone and norepinephrine drive, decreased γ - aminobutyric acid / benzodiazepine functioning, multiple alterations in the serotonergic system, and reduction in hippocampal volume, a brain structure vulnerable to the neurotoxic effects of stress - induced elevations in circulating glucocorticoids (e.g., cortisol) and amino acids (e.g., glutamate).

The hippocampus also highlights the importance of SE buffering, as supportive parenting in early childhood is associated with increased hippocampal volumes in middle childhood.49

Also, people with low self - esteem and depression react with more stress in several stressful situations, secretion of cortisol in their blood is higher and their hippocampal volume is reduced (Orth, Robins, Widaman, & Conger, 2014).

[12] McKinnon, M. C., et al. «A meta - analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder.»

Obese Adolescents with Type 2 Diabetes Mellitus Have Hippocampal and Frontal Lobe Volume Reductions

Compared with healthy controls, the hippocampal volume in PTSD patients (Bremner et al., 1995), adults reporting childhood physical and sexual abuse (Bremner, Randall et al., 1997), and a patient with DID (Tsai, Condie, Wu, & Chang, 1999) were decreased.

Increased volume in this brain region is associated with more optimal development of a number of psychosocial factors (e.g., stress reactivity).15 Links between early responsive parenting and increased volume in the hippocampal region also suggest that the early developmental period is an important time to facilitate responsive parenting practices, especially in high risk families, in order to enhance the parent - child relationship.

Research shows it has the potential to promote normal developmental trajectories for high - risk children, such as those from low - income backgrounds and / or those with very premature births.13 In contrast, unresponsive parenting may jeopardize children's development, particularly those at higher risk for developmental problems.14 The critical importance of responsive parenting is highlighted by recent evidence identifying links between high levels of early responsive parenting and larger hippocampal volumes for normally developing preschool aged children.