Sentences with phrase «with human bone marrow»

Not exact matches

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells.

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

The researchers used «humanized mice,» which have had their immune systems replaced with human immune system cells, thymus tissue and bone marrow.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

David Kaplan, Ph.D., professor and Director of the NIH P41 Resource Center on Tissue Engineering, Alessandra Balduini, M.D., and their collaborators have focused on forming bone marrow models with these components and other growth factors to imitate and support the formation of functional human platelets.

Human bone marrow (BM)- derived progenitor and stem cells administered with an appropriate scaffold represents a potentially exciting alternative treatment option [2], but only if we can discover a safe and rapid strategy to enhance the relatively low inherent osteogenic potential of BM.

In close collaboration with universities and physicians world - wide, our comprehensive investigational stem cell treatments employ well - targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells for the diseases listed below.

In separate experiments reported in Nature — one with mice, the other transplanting human stem cells into mouse bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cells.

The study assessed safety and efficacy of intracoronary autologous transplantation of bone marrow - derived human MSCs in patients with acute myocardial infarction.

The stem cell therapy done is from your own bone marrow and hence acceptability of the human body is more with no adverse effects

Patients receive one of two types of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own stem cells; or allogeneic, in which bone marrow - derived stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.

In the recent study, the researchers used CRISPR snipped out the sickle cell mutation from donated human bone marrow cells, and replaced it with non-mutated DNA.

Using primary murine bone marrow derived macrophages or human monocyte derived dendritic cells, infected with live or attenuated Chlamydia trachomatis we report that the live organism activates both canonical and non-canonical inflammasomes, but only canonical inflammasomes controlled IL - 1β processing which preceded pyroptosis.