Sentences with phrase «with human breast cancer»

Recent studies with human breast cancer cell lines have also shown that Shp2 mediates survival signals in cancer cells.

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

Not exact matches

NAMPA appears to imply that we should ignore advice such as this one issued on May 21st from Harvard's School of Public Health: «With increasing evidence of the potential harmful effects of BPA in humans, the authors believe further research is needed on the effect of BPA on infants and on reproductive disorders and on breast cancer in adults.»

«Very low doses [of BPA]-- below the amounts that are present in humans — when, particularly, exposure occurs in fetuses and newborns, you end up with those babies eventually developing prostate cancer, breast cancer.

A number of witnesses were to testify in favor of a marriage equality plank in the platform: Marc Solomon, national campaign director for Freedom to Marry; Allison Herwitt, legislative director for the Human Rights Campaign; Army Chief Warrant Officer Charlie Morgan, a lesbian New Hampshire guardsman with stage - four incurable breast cancer and a plaintiff in Servicemembers Legal Defense Network's lawsuit against the Defense of Marriage Act; Michael Macleod - Ball, the American Civil Liberties Union's chief of staff for the Washington Legislative Office; and Aaron Zellhoefer, a gay delegate to the Democratic National Convention representing the National Stonewall Democrats.

High total and saturated fat intake were associated with greater risk of estrogen receptor - and progesterone receptor - positive (ER+PR +) breast cancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer Instcancer (BC), and human epidermal growth factor 2 receptor - negative (HER2 --RRB- disease, according to a new study published April 9 in the Journal of the National Cancer InstCancer Institute.

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

Using the modified system, human melanoma and breast cancers as well as mouse melanoma cells were diagnosed with greater ease and efficiency.

«Almost every human being is infected with one or more of these viruses, but most people never develop symptoms, much less breast cancer,» Friedenson said.

Using this biosensor in highly invasive breast cancer cells taken from rodents and humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.

Researchers have isolated exosomes from tumors and from blood of patients with breast cancer, and from blood of mice with human tumors grown after breast implantation in mice, called ortoxenogratfs.

Moreover, epalrestat, a drug that inhibits AKR1B1 and is approved in Japan to treat peripheral neuropathies associated with diabetes, was similarly able to block the growth and metastasis of human basal - like breast cancer cells.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

In many human breast cancers, Numb concentration is low and this is associated with a poor prognosis for the patients.

The analysis also found that Asian / Pacific Islander women were more likely to be diagnosed with another subtype of breast cancer: so - called human epidermal growth factor receptor 2 (HER2)- overexpressing breast cancer.

In tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cells.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mice.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

Therefore, his team, led by postdoctoral fellow Gayatri Arun, set out to discover what would happen if mice that model human metastatic breast cancer were bred with the mice lacking Malat1.

The next step was to find out which role Shp2 and its target genes play in human patients with breast cancer.

Four miRNAs associated with aggressiveness of lymph node - negative, estrogen receptor - positive human breast cancer

PALLAS: Palbociclib Collaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib with Standard Adjuvant Endocrine Therapy versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR +) / Human Epidermal Growth Factor Receptor 2 (HER2)- Negative Early Breast Cancer

To find out, Einstein's George Karagiannis spent nearly three years experimenting with lab mice whose genetic mutations make them spontaneously develop breast cancer, as well as mice given human breast tumors.

Furthermore, we have validated and extended the conclusions of our model system with a detailed analysis of Î ± 2 integrin gene expression and its significance in human breast and prostate cancer.

To uncover how groups of cancer cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed dishes of human pre-cancer and metastatic breast cancer cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.

Mucosal melanomas with mutations in CDK4 may respond to palbociclib or ribociclib, which have demonstrated activity in advanced hormone receptor — positive, human epidermal growth factor receptor 2 — negative breast cancer.

Pathobiology of the 129: Stat1 - / - mouse model of human age - related ER - positive breast cancer with an immune infiltrate - excluded phenotype.

The human breast cancer cell line SKBR3 was purchased from the Duke University Cell Culture Facility and was maintained in McCoy's 5A medium (Life Technologies) supplemented with 10 % FBS (Life Technologies) and antibiotics.

The study provides a new path forward in human research as about half of the breast cancers treated with this common cancer therapy do not respond well, say researchers at the Georgetown Lombardi Comprehensive Cancer Center, who led the multi-institutional rescancer therapy do not respond well, say researchers at the Georgetown Lombardi Comprehensive Cancer Center, who led the multi-institutional resCancer Center, who led the multi-institutional research.

Cultures of the human triple negative breast cancer cell line, HCC1806, were maintained in RPMI 1640 medium supplemented with 10 % FBS.

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.

In collaboration with Nanyang Technological University, experiments were also conducted to co-deliver paclitaxel and small interfering RNA (siRNA) targeting a protein that prevents cell death (Bcl - 2) to MDA - MB - 231 human breast cancer cell line.

To confirm specificity, supernatant from transfected or transduced HB1.F3 cells was incubated with MCF7, MCF7 / HER2, or BT474, a human breast cancer cell line that endogenously overexpresses HER2.

And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142 in human breast cancer cells and BCSCs.

We further confirmed that the protein level of APC was elevated in the human breast cancer xenograft cells transfected with the anti-miR-142-3p lentivirus (Figure 7B).

To confirm that these findings are applicable to the human BCSCs, we infected the human breast cancer cells with the anti-miR-142-3p-expressing lentiviruses and evaluated the ability to form the organoids derived from the human BCSCs.

To evaluate the role of miR - 142 in the growth of human breast cancers initiated by the human BCSCs, we infected human BCSCs isolated from a patient - derived human breast cancer xenograft (PDX) with the anti-miR-142-3p-expressing lentivirus or the control lentivirus.

Primary human breast cancer samples were obtained from the Dana - Farber Cancer Institute with patients» consent and institutional review board appcancer samples were obtained from the Dana - Farber Cancer Institute with patients» consent and institutional review board appCancer Institute with patients» consent and institutional review board approval.

We confirmed that the protein level of APC was elevated and the expression of miR - 150 was decreased in the human breast cancer xenograft cells transfected with the anti-miR-142-3p lentivirus (Figure 5E and Figure 7B).

Mitochondrial folate transport by SLC25A32 is yet unstudied for its contribution to oncogenesis, despite knowledge that the slc25a32 gene is amplified in human cancers (including > 40 % of breast cancers) and this amplification is associated with accelerated disease progression and death.

Epidemiologic data has shown that chronic depression, stress, and lack of social support are all risk factors for cancer.14 A study in humans even showed chronic depression and even the death of a mother during childhood to be associated with increased breast cancer in women.15 While we do not have concrete evidence in humans, animal studies more definitively point to stress as a cause of cancer.

Antioxidants and other active components of prickly pear induced early cell death in human breast and colon cancer cells, with a more pronounced effect occurring in colon cancer cells.

Cholesterol appears to stimulate the growth of human breast cancer cells — which may explain why phytosterol - rich foods, such as pumpkin seeds, are associated with reduced breast cancer risk.

(5, 6) In fact, the importance of sleep is only now becoming more widely recognized for its many impacts on human health, with links being established between sleep deprivation and blood sugar problems, high blood pressure, obesity, even breast cancer.

Originated 1970s by Dr. Henry Lemon, who tested estrogen levels in 24 hour urine samples and found that an EQ > 1 strongly correlated with a higher survival rate after breast cancer.24 Further research conducted by Lemon, Heidel, et al., a meta - analysis of published fractional estrogen excretion collected from 2,846 healthy women worldwide aged 15 to 59 years, with a risk of breast cancer varying five-fold, found that an EQ < 1 reflects increased rates of oxidation of estrone or estradiol to 4 - OH catechols (also referred to in the literature as the 3,4 - catechol estrogen quinones), which have been identified as the principal proximal human mammary carcinogens after menarche, while an EQ > 1 reflects conversion to protective 2 - OH estrogen metabolites.2526

(21 - 22)(39) Three previous large scale human studies revealed increased breast cancer with progestin use.