Working
with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.
Not exact matches
The team also tested
human milk samples from subjects
with mastitis, an infection of the
breast tissue that causes pain and inflammation.
In tests on
human breast cancer cells and in special immunodeficient mice
with tissue grafts, the scientists found that both agents interfered
with genes involved
with breast cancer cell growth, resulting in more cancer cells.
They compared normal, non-cancer-forming
human breast tissue cells
with cancerous
breast cells using both of these treatments, contrasting them
with cells
with unmanipulated mtDNA.
Rudensky's team compared Tregs in normal
human breast tissues with those found in untreated
breast tumors, and found that Tregs in tumors were capable of more potent and aggressive immunosuppressive action.
PDBEs can accumulate in
tissues and in fat cells,
with traces being found in
human breast milk.