Sentences with phrase «with human lung»

«We developed a new method of initiating lung cancer in mice, which has properties associated with human lung cancer, and used this model to identify the role of this enzyme in cancer proliferation.

In the second study in Science, researchers from Harvard University in Boston, Massachusetts, created a chip 1 to 2 centimeters long in which a 1 millimeter - wide channel, coated with human lung cells on the inside and overlaid with human blood capillaries on the outside, mimicked the air sacs, or alveoli, of the lungs.

When mice that had been implanted with human lung tumours inhaled these bubbles — which also contained molecules that suppress drug resistance — their tumours shrank.

Not exact matches

But with the exception (perhaps) of some infections, human disease, including lung cancer, is rarely «caused» by one (and only one) thing.

By printing multiple lung airways — or any other afflicted organ — from a human patient and testing drugs on them, pharma companies can bypass the ethically challenged practice of testing on animals and proceed to human clinical trials with greater confidence the drugs will actually work, according to Wadsworth.

With the victims of lung cancer we have the good sense to respond at the point of human suffering rather than the point of moral judgment.

The police had nabbed Ajibade with a fresh human head and other body parts like hands, lungs, liver and blood, which was kept inside a bottle during a stop and search operation in Osogbo, the state capital.

Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory - grown, human airway cells that a condensed form of cigarette smoke triggers so - called «epigenetic» changes in the cells consistent with the earliest steps toward lung cancer development.

To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

Scientists have long experimented with organs - on - chips: tiny representations of human organs, such as lungs, hearts and intestines, made from cells embedded on plastic about the size of a computer memory stick.

Air leaving the lungs is 78 percent nitrogen, 16 percent oxygen, and 4 percent carbon dioxide — depleted in oxygen and enriched more than a hundredfold in carbon dioxide compared with what went in, due to human metabolism.

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular «off» switch for the inflammatory immune response that contributes to lung - constricting asthma attacks.

The scientists also studied lung tissue from humans with asthma and healthy controls.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

Their major hurdle: to come up with a replacement for hemoglobin (an iron - enriched protein in red blood cells that transports oxygen from the lungs to the rest of the body) that can be directly introduced into the human circulatory system.

Using both fruit fly and human lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).

In humans and most of the higher animals, closing off air - filled lungs with this valve mechanism also stabilizes the body during muscular exertion, including evacuation of the bowels.

Contributing to the work were researchers from the National Human Genome Research Institute (NHGRI), the National Institute of Allergy and Infectious Diseases, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Heart, Lung, and Blood Institute and the NIH Clinical Center, all part of NIH, along with their colleagues in Turkey and the United Kingdom.

This tiny chip made from a polymer and loaded with human cells is designed to serve as a miniature replica of a human lung.

But with humans, she is using iPS cells and has been working to develop the correct protocols to induce her stem cells to differentiate into different kinds of lung tissue.

All of these findings were supplemented with several other experiments that were designed to learn how CHI3L1 interacts with other cells involved in the tissue repair response in both human and mouse lungs.

When the team turned to human lung cells, they found that A20 was also less active in adults with asthma.

He found that red ginseng extract improves the survival of human lung epithelial cells infected with influenza virus.

The team also found that antibodies to human surfactant proteins called SP - A and SP - B reacted with proteins taken from the fish, implying that both use the same «anti-glue» to keep their lungs open.

Their findings, reported in Nature Communications, may shed light on human lung disease, in particular, the mechanism behind non-familial pulmonary hypertension in patients with conditions such as emphysema and pulmonary fibrosis.

The form of Vitamin E called gamma - tocopherol in the ubiquitous soybean, corn and canola oils is associated with decreased lung function in humans, the study reports.

The researchers also tested human lung tissue of premature infants with BPD and found similar levels of increased autophagy.

After nestling inside the human lung, they can cause a severe infection that, if not treated with antibiotics, kills 90 % of those it infects.

The cells exhibited many functions associated with tumor progression; their presence within mouse tumors substantially accelerated cancer growth, and in human lung tumors, a SiglecFhigh neutrophil signature was associated with poor patient survival.

In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapy.

The researchers next showed that the Smurf1 gene controls M. tuberculosis growth in human macrophages and that the Smurf1 protein was found in association with bacteria in the lungs of patients with tuberculosis infections.

This week it emerged that the first human test of the controversial gene - editing technique CRISPR had taken place at West China Hospital in Chengdu, where oncologists used it to treat a man with an aggressive lung cancer.

Francis Collins, director of the National Human Genome Research Institute (NHGRI)-- which is funding this initiative jointly with the National Heart, Lung, and Blood Institute — says that having the genomes of three of the most important mammals in biomedical research in hand «will greatly speed the unraveling of the genetics and physiology» of human disHuman Genome Research Institute (NHGRI)-- which is funding this initiative jointly with the National Heart, Lung, and Blood Institute — says that having the genomes of three of the most important mammals in biomedical research in hand «will greatly speed the unraveling of the genetics and physiology» of human dishuman disease.

According to Earl Brown, professor of medicine at the University of Ottawa, the more limited ability of the avian flu virus to infect cells in the human airway thus also appears to be associated with infection of the deep areas of the lung where oxygen and carbon dioxide are exchanged.

IHC - P mouse tumor tissue (from lung) with human cell line injected, some muscle tissue attached as well sees high background for human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...

Wang's team discovered that if human lung cancer cells in a lab dish in the presence of the receptor were treated with BCX, they migrated less than untreated ones.

Management of chemotherapy - related anaemia with low - dose recombinant human erythropoietin in patients with small cell lung cancer.

The public disclosure of this expanded collaboration coincides with the publication in the peer reviewed journal Nature Methods of data showing new capabilities of the Lung - Chip technology to achieve accurate modeling of the human lung small airwLung - Chip technology to achieve accurate modeling of the human lung small airwlung small airways.

Thomson's group created human iPS cells using fetal lung cells and foreskin cells with two of the same factors as Yamanaka, along with two different factors.

Building on that project, the researchers have now designed a machine that smokes cigarettes in a very human - like manner, and hooked it up to organs - on - chips lined by human lung small airway cells so the smoke interacts with these cells in a realistic way.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

Mutation rates ten-fold higher than typical lung cancers in humans, though within three-fold of «hypermutator» tumors with mutations in DNA repair genes.

I wanted to inactivate the gene BRAF (a kinase implicated in several human cancers) in A549 cells (a human lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).

(a kinase implicated in several human cancers) in A549 cells (a human lung cancer cell line), armed only with viruses obtained through Addgene's viral service and the methods sections of scientific articles (gasp).

Normal human lung fibroblasts (NHLF) cells grown in 384 - well Optilux plates were treated with candidate compounds and incubated for 18 hours prior to fixation and staining with Hoescht dye and anti-HMOX1 antibody as described in Materials and Methods.

«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms on human lung cancer cells».

Title of thesis: «Study of the pro-apoptotic effect of histones deacetylases inhibitors, used alone and concurrently with chemotherapeutic agents, on human lung cancer cells».

In this study, human lung cancer cells with additional copies of the opioid receptor grew more than twice as fast as tumor cells that lacked extra receptors when transplanted into mice.

Each of Emulate's proprietary Organ - Chips — such as the lung, liver, brain, intestine or kidney — contains tiny hollow channels lined with tens of thousands of living human cells and tissues, and is approximately the size of an AA battery.

San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.