Sentences with phrase «with human sequences»

So far, two - thirds of HARs tested for enhancer activity turned on a gene during development.4 For 26 HAR enhancers, we repeated the experiment with the human sequences.

Biologist Sydney Brenner of the Salk Institute in La Jolla, California, who won a Nobel in 2002 and led the team that did the sequencing, says his next step is to compare it with the human sequence in order to identify regions that have changed little in the 450 million years since the two lineages split.

To facilitate biomedical studies comparing regions of the chimp genome with similar regions of the human genome, the researchers also have aligned the draft version of the chimp sequence with the human sequence.

Not exact matches

Sequencing in one 18 - year - old patient found several oncogenes, and her and her family will continue to work with Human Longevity to monitor the cells.

The collection of that data — the genetic sequences of 160,000 citizens, along with their medical and genealogical records — was made possible by the Icelandic government, and the storage and analysis of that data was overseen by deCode, a Reykjavík - based human genetics outfit that, since its founding in 1996, had struggled to stay afloat financially.

Aug. 30, 2012: The genome of a recently discovered branch of extinct humans known as the Denisovans that once interbred with us has been sequenced

Of course the sequencing is not quite right, because the poem was written / inspired (take your pick) before science did its work.But the intuitive observer could see a clear evolution form plants to animals to human life, with continuities and differentiations.

Aug. 30, 2012: The genome of a recently discovered branch of extinct humans known as the Denisovans that once interbred with us has been sequenced Anyone find fossils of Adam and Eve yet?

How far this creativity can go in creating the human level in the case of any one individual depends partly upon his innate capacity but most of all upon two other features: (1) how wide and deep is the volume of history that reaches him, that is, how abundant and coherent are the values that have been accumulated in the history he inherits and (2) how deep is the communion he is able to have with other persons who embody these meanings accumulated through a long sequence of generations.

In this view, when the primitive idea of God, which was based on the personification of powers of nature, vanishes gradually behind the infinitude of the causal sequence, the concept of God gains in coherence and consistency in proportion as it achieves a firm position in connection with the claims and needs of the human spirit, and becomes the «irreducible coefficient of the achievement of moral processes in self - consciousness.»

It is the journey of primordial matter through its marvelous sequence of transformations — in the stars, in the earth, in living beings, in human consciousness — toward an ever more complete spiritual - physical intercommunion of the parts with each other, with the whole, and with that numinous presence that has been manifested throughout this entire cosmic - earth - human process.

It may be that the later alienation of young adults from the redemptive tradition is, in some degree, due to this inability to communicate to the child a spirituality grounded more deeply in creation dynamics in accord with the modem way of experiencing the galactic emergence of the universe, the shaping of the earth, the appearance of life and of human consciousness, and the historical sequence in human development.

The easiest way to understand this would be to regard God, like human persons, as a living person.30 A living person is a succession of moments of experience with special continuity.31 At any given moment I am just one of those occasions, but when I remember my past and anticipate my future, I see myself as the total society or sequence of such occasions.

Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria» — Desai et al reported on the effects of different diets with different fibre content.

Craig Venter (which helped to sequence the human genome) announced that it had created the first - ever synthetic, self - reproducing microbe with synthetic biology.

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

BOSTON — For bee researchers like May Berenbaum, 2006 was the year an international consortium of researchers published the first full sequence of the honeybee genome, offering a unique and long - sought glimpse at the biological quirks of an insect that shares a productive history with humans.

In a study published last June in the Journal of Human Genetics, researchers sequenced the mitochondrial DNA of 12 Yamnaya individuals, along with their immediate predecessors and descendants.

One way to home in on the functional areas is to scan for sequences that humans share with other mammals, suggesting they have been conserved for a reason.

The team found that humans are equipped with tiny differences in a particular regulator of gene activity, dubbed HARE5, that when introduced into a mouse embryo, led to a 12 % bigger brain than in the embryos treated with the HARE5 sequence from chimpanzees.

And with the recent unveiling of the human genome sequence — to say nothing of the new drugs that are being tested every day — those working in the patent field are busier than ever.

Moreover, data collected from whole - genome sequencing showed that Ata's molecular composition aligned with that of a human genome.

Now Pääbo and his colleagues have devised a new method of genetic analysis that allowed them to reconstruct the entire Denisovan genome with nearly all of the genome sequenced approximately 30 times over akin to what we can do for modern humans.

And in the United States, the National Human Genome Research Institute in Bethesda, Maryland, recently funded three Mendelian Disorders Sequencing Centers that will apply genome sequencing to diagnosing thousands of patients with a wider range of rare diseases, including intellectual disability and developmenSequencing Centers that will apply genome sequencing to diagnosing thousands of patients with a wider range of rare diseases, including intellectual disability and developmensequencing to diagnosing thousands of patients with a wider range of rare diseases, including intellectual disability and developmental delay.

The team sequenced the gene that codes for the NaV1.7 channel in mole rats, and compared it with SCN9A — a key gene in the human version of the channel.

Weiner, Elliott and colleagues studied the DNA sequences for two human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.

The DNA sequence from a male hunter - gatherer also offers tantalizing clues about modern humans» journey from Africa to Europe, Asia and beyond, as well as their sexual encounters with Neanderthals.

Incompatibility between the two software packages used caused some variants that the Ethiopian man shared with Europeans (whose DNA forms a large chunk of the human reference sequence) to be removed from the analysis.

«We explored the opportunity of using sperm RNA elements as a predictor of human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and Develophuman health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and DevelopHuman Growth and Development.

The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA.

By comparing it with that of modern humans, chimpanzees and bonobos, plus Neanderthals and Denisovans, Meyer estimated its age at 400,000 years, twice as old as our own species and far older than any hominin genome previously sequenced (Nature, DOI: 10.1038 / nature12788).

Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously sequenced microbial genomes.

All that changed this month, with the publication of a 400,000 - year - old mitochondrial genome sequenced from the remains of an early human found in a cave in Spain.

The AcrA - PPMO also was effective against the human pathogens Klebsiella pneumoniae and Salmonella enterica, since those bacteria contain the same efflux pump with a matching gene sequence, Dr. Greenberg said.

In 2014, the company officially launched the Regeneron Genetics Center, which forms diverse private — public collaborations to gain disease insights and find targets by pairing human DNA sequences with electronic health records.

«With large present - day genomic datasets and increased international collaboration to handle the many newly sequenced ancient datasets, there is huge potential to understand the biology of human prehistory in a way that has never been accessible before.»

Cell - free genomic DNA isolated from human cells was cleaved with preassembled, recombinant Cpf1 RNPs and subjected to whole - genome sequencing.

The Palaeogenomics study conducted by the Human Evolutionary Biology group of the Faculty of Science and Technology, led by Concepción de la Rua, in collaboration with researchers in Sweden, the Netherlands and Romania, has made it possible to retrieve the complete sequence of the mitogenome of the Pestera Muierii woman (PM1) using two teeth.

To reach this conclusion, Pääbo and his team spent years sequencing the complete genome of three Neanderthal bones from the Vindija Cave in Croatia and compared the results with the genomes of five modern humans from southern Africa, West Africa, Papua New Guinea, China, and Western Europe.

Using DNA sequencing, scientists have learned that anatomically modern humans interbred with Homo neanderthalensis, or the Neanderthals, probably around 60,000 years ago in the Middle East, before they fanned out to populate Europe and Asia.

New, sophisticated gene sequencing techniques are leading to an increasing understanding of the causes of genetic disease, and can help parents with affected children make informed reproductive choices, the annual conference of the European Society of Human Genetics will hear.

«The Neandertal genome sequence just by itself will not tell us what makes humans special, it will always be in conjunction with other work that really addresses the biology of a specific change,» he says.

The sequencing of the human genome is gearing up all those efforts, and with each novel model organism for which the sequence has been determined, the power of comparative analysis increases.

Coffin and his collaborator, Vinay Pathak, suggested that with each passage, the human cells acquired genetic portions of a murine leukemia virus, which then merged to form a new virus — a hybrid of the parent sequences.

People with heart disorders also have higher than average levels of certain bacteria, according to genomic sequencing of the human gut.

Richard Walker of the University of South Florida College of Medicine in Tampa and his team are comparing the DNA of «teen baby» Brooke Greenberg, from Baltimore, Maryland, with that of her three healthy sisters, her parents and standard human DNA sequences in the human genome database.

The oldest DNA of a modern human ever to be sequenced shows that the Homo sapiens who interbred with the Neanderthals were very modern — not just anatomically but with modern behaviour including painting, modern tools, music and jewellery.

This group found that DNA damage was repaired when human hereditary disorder type mutations (xrs2 mutations) were introduced in yeast XRS2 genes, but it was repaired with more errors than a DNA sequence with no mutations.

«In regions of the chromosome where we can align all three species, the sequence similarity fits with what we know about the evolutionary relationships among the species — humans are more closely related to chimpanzees.

The researchers also found evidence that killer whales can learn completely new sounds: one killer whale that was living with dolphins at the time of the experiment learned to produce a chirp sequence that human caretakers had taught to her dolphin pool - mates before she was introduced to them.