Sentences with phrase «with human variation»

Not exact matches

Is the human intellectual concept of personhood applied to an anencephelic fetus, and which ones with all the various genetic variations of the condition where the fetus has no brain, or part of a brain?

We are accustomed to regard a man as an individual of the species «man,» a being endowed with definite capacities, the development of which brings the human ideal in him to realization — of course with variations in each individual.

Rather, it is a variation of these along with the demonry of personality itself, of man's moral and rational capacities in tension with the sensitivities of spirit as a higher dimension of freedom and goodness which grasp him as a novelty of grace within his human structure, judging him, yet summoning him to that which is beyond his own human order of good.

With variation, but in essential correspondence of members of the plot, it happened of course throughout the spreading human family in the centuries and years, perhaps even months or days, preceding; and it has most assuredly continued to happen, in its significant essence, with persistence and always accompanying human carnage down to our own time and decade and, who knows, even day and hWith variation, but in essential correspondence of members of the plot, it happened of course throughout the spreading human family in the centuries and years, perhaps even months or days, preceding; and it has most assuredly continued to happen, in its significant essence, with persistence and always accompanying human carnage down to our own time and decade and, who knows, even day and hwith persistence and always accompanying human carnage down to our own time and decade and, who knows, even day and hour.

They derive from some of the most basic approaches to the riddle of human existence imaginable, Each of these options and their variations have sustained and continue to sustain vast segments of the human population in their attempts to cope with life and death, and are living options today.

The presumed duration of the whole human development (a few million years) is so trifling compared with the extent of astronomic time, even at the lowest estimate, that the chance of a variation of the solar equilibrium while the anthropogenesis is in process may be ignored.

I went to the Answers in Genesis Web site and found an article about how these recent findings «should in no way faze creationists» because «the fossil does not resemble a human skeleton,» because it «was found in two parts,» and because the fossil's lack of a grooming claw and toothcomb «are easily explained by variation with a kind.»

While there are significant variations, nuances, and many open questions, such as whether to characterize the absence of estrus in humans as «concealed ovulation» or a form of «permanent estrus display,» the dominant assumptions appear to be remarkably consistent with George's.

The author, a certified health and nutrition counselor who teaches whole foods cooking, enthusiastically endorses human milk for baby's best start in life, and offers nutritious, almost entirely meatless recipes, with variations for adapting each recipe for babies and children.

Over 100 different oligosaccharides have been identified in the human colon, and recent research has shown that variations in the oligosaccharides within the mucus are associated with variations in the composition of the gut microbiota.

I continued working at the interface of science and epidemiology, first with Genaissance Pharmaceuticals, a New Haven - based pharmacogenomics company, where I was involved in the fascinating study of human genetic variation and population genetics.

Next, although science may come closer to universality than any other human activity, there are distinct local variations, as scientists adapt to local constraints and approach science with ways of thinking that are influenced by local culture, and these different ways of doing science can teach us things.

Our genomes are strewn with millions of rare gene variations, the result of the very fast, very recent population growth of the human species.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

Scientists have found a variation of the miR - 182 gene in patients with primary open - angle glaucoma that results in this overexpression, said Dr. Yutao Liu, vision scientist and human geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.

Adds Visscher: «This is entirely in line with theory and previous inference from SNP [variant] data, yet for some reason many researchers in human genetics and epidemiology continue to believe that there is a lot of non-additive genetic variation for common diseases and quantitative traits.»

It is a common issue with nutrition studies, she notes — given the vast diversity of human research subjects, variations in the concentration or mixture of supplements, and often uncontrolled factors such as baseline diets or preexisting illnesses, it's not unusual to see different studies canceling each other out.

«Right now, the research group is analyzing the nuclear genome the results of which could provide us with information about its relationship with the Neanderthals and about the existence of genomic variations associated with the immune system that accounts for the evolutionary success of Homo sapiens over other human species with whom it co-existed.

Variation in pigmentation among human populations may reflect local adaptation to regional light environments, because dark skin is more photoprotective, whereas pale skin aids the production of vitamin D. Although genes associated with skin pigmentation have been identified in European populations, little is known about the genetic basis of skin pigmentation in Africans.

Being nice «The great complexity of human social interactions and the huge variation in what we find rewarding compared with other primates prompts questions about whether the anterior cingulate gyrus operates similarly in the human brain,» Matthew Apps and Narender Ramnani, who work on neuroimaging and human cognition at Royal Holloway, University of London, UK, told Nature in an email.

They also compared the human genomes with recently sequenced genomes of Neanderthals and Denisovans and found similar genetic variation, which indicates that the facial variation in modern humans must have originated prior to the split between these different lineages.

To decipher how cells perform this recognition task, Tsao and postdoc Steven Le Chang generated 2,000 human mug shots with variations in 50 features, including facial roundness, distance between the eyes, and skin tone and texture.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

In humans, glucose tolerance varies with time of day, but the mechanism responsible for the variation in insulin sensitivity throughout the day is unclear.

The result, says Goodfellow, was that «until 1980, the human genome was a markerless desert with the occasional oasis of polymorphism (variation)».

Researchers have discovered that protection from the most severe form of malaria is linked with natural variation in human red blood cell genes.

«The PRSS53 enzyme functions in the part of the hair follicle that shapes the growing hair fiber, and this new genetic variation, associated with straight hair in East Asians and Native Americans, supports the view that hair shape is a recent selection in the human family.»

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, Human Genetics on October 2, 2014.

Co-author Heidi Parker, a geneticist at NHGRI, says that because humans initially bred dogs for specific traits — say, smaller body size or calm temperament — selection created a population «bottleneck» that narrowed the genetic variation in offspring, leaving them with just a few specific clusters of variable genetic regions.

This is also the first study to attempt to correlate performance on this test with variation in the human genome.

But new genetic studies of ancient DNA from Neandertals have found that they and the last ancestor they shared with humans, about 600,000 years ago, also lacked much genetic variation, which would require at least three dramatic bottlenecks — an improbable scenario.

The work on gorilla and other human genomes clearly demonstrates that large swathes of genetic variation can't be understood with the short sequence - read approaches.

In fact, claims that size variation in Australopithecus and / or Paranthropus was larger than that in recent human populations include inferences on sexual dimorphism (Richmond and Jungers, 1995; Plavcan et al., 2005; Lockwood et al., 2007; but see Reno et al., 2003), whereas arguments referring to early Homo are usually associated with eco-physiological variants (Antón et al., 2014; Di Vincenzo et al., 2015).

The team selected possible leads from the intersection of more than 20,000 p53 binding sites in the human genome, 10 million inherited genetic variations genotyped in the 1000 Genomes Project, and 62,000 genetic variations associated with human cancers identified in genome - wide association studies (GWAS).

Mice inserted with a rare human genetic variation in the dopamine transporter could lead to improvements in the diagnosis and treatment of brain disorders.

«Then I learned about connections with history and how you can infer human history from DNA variation, and I was hooked.»

Model simulations of 20th century global warming typically use actual observed amounts of atmospheric carbon dioxide, together with other human (for example chloroflorocarbons or CFCs) and natural (solar brightness variations, volcanic eruptions,...) climate - forcing factors.

The paper itself is very statistical in nature, with various «selection models» applied to determine the demographic and selective effects on amino acid variation in the human genome.

It follows from the last point above that the vast majority of common human genetic variation, i.e. SNPs with derived allele frequencies of at least 5 %, is neutral or nearly neutral with respect to fitness.

In collaboration with Dr. Josh Thaden and Vance Fowler, Duke University Medical Center, we are exploring relationships between bacterial genetic variation, emergence of AMR, and patient outcome in Enterobacter and Escherichia coli Bloodstream Infections (BSI) by leveraging the Duke University Bloodstream Infection Biorepository (BSIB), which contains robust clinical data, bacterial bloodstream isolates, and corresponding human sera and DNA from over 2000 patients with BSI caused by Gram - negative bacteria at Duke Hospital since 2002.

That can make it hard to make subtle changes to a gene — like introduce point mutations corresponding to natural variations linked with human disease — without taking a sledgehammer to the entire gene locus.

Monitoring, understanding, and predicting oceanic variations associated with natural climate variability and human - induced changes, and assessing the related roles of the ocean on multiple spatial - temporal scales.

The Kwiatkowski group investigates Plasmodium, Anopheles and human genome variation in large clinical and epidemiological studies carried out with partners in over 20 malaria - endemic countries.

By analyzing these two exomes together with the genome sequence of a Neandertal from Siberia we show that the genetic diversity of Neandertals was lower than that of present - day humans and that the pattern of coding variation suggests that Neandertal populations were small and isolated from one another.

Dosing of mebendazole of 30 - 87 mg / kg / day in humans resulted in plasma levels of 120 -218 nM (260 nM for continuous administration) with coefficients of variation ranging from 27 to 72 %.

Working with collaborators in more than 20 countries, primarily through MalariaGEN, Dominic's research focuses on investigating the biological and clinical consequences of genomic variation in human, Plasmodium and Anopheles populations.

The challenge for the years to come is to convert data on new genes, gene defects and human genome variation in patients with genetic cardiovascular disease into functionally relevant information on the diverse pathophysiological mechanisms and clinical manifestations.

A Scottish human population with and without diabetes, reported a high degree of variation between female and male first generation offspring throughout transgenerational transmission of unfavorable cardiometabolic traits (158).

The Center for Research on Genomics and Global Health (CRGGH) aims to facilitate a global understanding of the relationship between human genetic variation and population differences in disease distribution, with the ultimate goal of informing health inequalities.