Although many of the components of this syndrome, such as cognitive, sensory, and motor disabilities, are shared by other congenital infections, 5 features differentiate CZS from other congenital infections: (1) severe microcephaly
with partially collapsed skull; (2) thin cerebral cortices
with subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) congenital contractures; and (5) marked early
hypertonia with symptoms of extrapyramidal involvement (Table).