Not exact matches
These results are aligned
with previous
infliximab antibody data among patients
with inflammatory bowel diseases being treated
with Remicade.
ew data presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) show that the newly - approved
infliximab biosimilar CT - P13 achieves statistically similar improvements in disease activity, disability and mobility in patients
with Ankylosing Spondylitis (AS) compared to its original reference product
infliximab (INX).
The study, published in the Inflammatory Bowel Disease Journal, evaluated the levels of
infliximab, an antibody designed to bind to and block the effects of TNF - alpha, an inflammatory protein found in high levels in patients
with IBD, such as Crohn's disease and ulcerative colitis, and numerous other inflammatory conditions such as rheumatoid arthritis and psoriasis.
In 2009,
with that standard in mind, BIDMC attending physician Adam S. Cheifetz, MD began monitoring
infliximab levels in his IBD patients
with the goal of gradually adjusting their dosing regimens to hopefully improve long - term efficacy and decrease toxicity.
«Prolonging
infliximab's efficacy and avoiding surgery and hospitalization is very important for patients
with IBD,» said Cheifetz.
For this multicenter retrospective study, Cheifetz and colleagues analyzed the long - term outcomes of 264 patients
with IBD on
infliximab maintenance at either BIDMC or University of Pennsylvania hospitals, just under half of whom were monitored proactively.
The major players in the arthritis drug market include Remicade ® (
infliximab), Humira ® (adalimumab), Enbrel ® (etanercept), Cimzia ® (certolizumab pegol) and Simponi ® (golimumab), while biosimilars of the above as well as new drugs
with novel mechanisms of action are under development.
May 21, 2000 Study shows
infliximab can maintain long - term remissions in Crohn's disease Periodic treatment
with the monoclonal antibody
infliximab can prolong remissions in patients
with moderate to severe Crohn's disease.
In one recent trial, 9 a subset of patients resistant to antidepressant treatment and identified by serum markers of inflammation, most notably C - reactive protein > 3mg / L, were responsive to treatment
with the TNF - alpha antagonist (anti-inflammatory)
infliximab (Remicade).
Clicking thru to the main study you discuss, I noted a paragraph near the end that states that the semi-vegetarian diet is «effective for relapse prevention,» but that the authors» concern
with «rapid, safe and reliable» induction of remission, which they say they achieve via
infliximab.
Peripheral neuropathy in two patients
with rheumatoid arthritis receiving
infliximab treatment has been reported >
The researchers in the study found that 62 percent of depressed people
with high blood levels of C - reactive protein had a reduction in their depression while taking the
infliximab, while only 33 percent of those
with normal CRP levels noted improvement.