Sentences with phrase «with laboratory mice»

For example, Tan & Counsilman (1985) have shown a strong correlation between early weaning and killing behavior in an experiment with laboratory mice as prey.

Longevity trials were conducted over a period of several years with laboratory mice receiving antioxidants in their everyday food.

- CNR has applied for and obtained the ethical and sanitary approval of the planned experimental activities with laboratory mice, including those to be carried out as part of the INFRAFRONTIER - project.

The fundamental genetic similarity between mice and humans allows researchers to infer a human gene's function based on studies with laboratory mice.

Their work with laboratory mice also provides a greater understanding of how this gene impacts Menkes disease as scientists search for a treatment.

The research was done with laboratory mice that consumed different diets and then faced a variety of tests, such as water maze testing, to monitor changes in their mental and physical function, and associated impacts on various types of bacteria.

In experiments with laboratory mice, Ramirez and his colleagues distinguished two groups of pacemaker neurons that govern breathing.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

However, in some studies with laboratory mice, Feinberg had observed that these epigenetic tags varied considerably among the mice even when comparing the same type of tissue in animals that have been living in the exact same conditions.

Testing with laboratory mice have shown negative impacts on respiratory, digestive, and reproductive systems, among others.

Not exact matches

What's more, an ointment containing the peptide effectively treated wounds infected with methicillin - resistant Staphylococcus aureus (MRSA) and the increasingly common hospital infection bacterium Acinetobacter baumannii in mice and on laboratory samples of human skin.

Also, it is reassuring that our results of improved motor unit dysfunction in SMA mice treated with RG3039 mirror the independent findings by the laboratories of Drs. Sumner and Ko.

With no more than a change in diet, laboratory agouti mice (left) were prompted to give birth to young (right) that differed markedly in appearance and disease susceptibility.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

Although the researchers emphasized that laboratory results involving cell lines and mice do not necessarily translate to human treatment, they say their findings show that new mTOR inhibitors combined with chemotherapy could become a new treatment strategy for T - ALL.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Diseases.

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

With the move to India, Colleen left the lab bench so that she could coordinate the development of facilities at inStem; this included new laboratory space and an animal facility housing mice, rats, fish, and frogs.

With researchers at the Jackson Laboratory in Bar Harbor, Maine, George and colleagues transplanted mouse skin to 19 mice.

Moreover, in separate experiments conducted in the United States, treatment with antimalarials did not affect survival in laboratory mice infected with Ebola virus.

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

So far, they have worked with only small laboratory rodents — mice and rats.

The study, which Shay conducted with colleagues at the University of Florida and University of Nebraska, complements work with mice he leads at his OSU laboratory.

In 2005, Rudolf Jaenisch's laboratory at Whitehead reported preliminary success with this strategy, using mouse cells.

Stix: His laboratory is at the Scripps Research Institute in La Jolla very near San Diego and what he showed is that this process could be blocked in mice, but they actually have to come up with a small molecule that is non-toxic.

Likewise, male mice with a Rett mutation have much more severe symptoms than the females do, says Zhong - wei Zhang, associate professor at the Jackson Laboratory in Bar Harbor, Maine.

Denis Duboule and his colleagues at the European Molecular Biology Laboratory in Heidelberg, working with mice, showed that genes in the Hox - D cluster, which define the head - to - tail body axis, are activated one after another and at a precise time during development of the embryo.

In the Rutgers study, Zong and lead author Ji - An Pan, a scientist in his laboratory, looked at liver and heart damage in laboratory mice and found that the mice in which the TRIM21 gene was inactivated suffered little heart or liver damage when put through the same laboratory procedures used to produce tissue damage in mice with the gene.

She worked with reproductive biologist and endocrinologist Susan Nagel of the University of Missouri, Columbia, whose laboratory collected the mouse mammary tissue samples exposed to the UOG chemical mix.

They also showed in mice studies and in the laboratory that NCAM2 was broken down by another protein called beta - amyloid, which is the main component of the plaques that build up in the brains of people with the disease.

In both laboratory dishes and mice with human prostate cancers, the nanoparticles proved extremely effective.

In research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humans.

For example, it could be used to image neurons in living mice by combining the Raman scattering technique with existing methods in which tiny windows are implanted in the brains and spinal cords of laboratory animals.

Prusiner, together with Fred Cohen and his colleagues, also at UCSF, and Ruth Gabizon at Hadassah University Hospital in Israel, used human prions to infect a special strain of laboratory mice.

In laboratory testing, the researchers were able to improve symptoms of the disease in mice, raising hopes that they may have found an avenue for treating people with CMT.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

The laboratory where this discovery was made is now planning to study mice presenting with defective MOCOS expression in order to analyze how the enzyme and its regulators influence the development of the nervous system.

As an example, Martin von Lohuizen of the Netherlands Cancer Institute, says Berns's own laboratory has developed a mouse with a gene called PIM1 which rarely causes tumours but sensitises the mouse to the action of a second carcinogen.

Researchers at Cold Spring Harbor Laboratory have identified the neurons in the brain that determine if a mouse will learn to cope with stress or become depressed.

«Mouse models don't represent the full diversity of the human response,» said Joel W. Blanchard, a PhD candidate in the Baldwin laboratory who was co-lead author of the study with Research Associate Kevin T. Eade.

Working with mice in the laboratory, he quickly realized the benefits of the mantra of caloric restriction research: undernutrition without malnutrition.

After introducing stem cells in brain tissue in the laboratory and seeing promising results, Prof. Offen leveraged the study to mice with Alzheimer's disease - like symptoms.

Several laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of Medicine, have demonstrated that transplanting inhibitory neurons from healthy mice has improved symptoms in mice with models of those diseases.

A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome (AS)-- a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.

A team of neuroscientists has identified a modification to a protein in laboratory mice linked to conditions associated with Alzheimer's Disease.

In a series of laboratory trials, mice given BU10119 demonstrated behaviours consistent with providing antidepressant - like effects.

Laboratory mouse models are commonly used to study A-T; however, mice with A-T do not experience the more debilitating effects that humans do.

Working with mouse prostate cancer cell lines in the laboratory, the investigators found that cells containing overexpressed TOP2A and EZH2 genes were highly sensitive to attack with a combination of two drugs.