Since biological systems challenge the available methods, and the necessary foundations in physics, computer science, and mathematics are often missing, the CellDevo track greatly benefits from the fundamental research in computer science, bio-image informatics, biophysics, and applied mathematics represented in the CompBio and BioPhysEng tracks and help to develop the methodological foundations for future biology in tight integration
with life imaging and other experimental approaches.
We exploit chick and mouse embryo animal models, combined
with live imaging, cell and tissue cultures and molecular approaches.
We address these questions by combining genetics
with live imaging, quantitative image analysis and biophysical approaches using the fruit fly Drosophila melanogaster as a model organism.
Not exact matches
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The latest in
live - cell microscopy — multiphoton
imaging, light - sheet techniques, and technology borrowed from Raman spectroscopy — allow researchers to study
living cells in more detail
with less effort.
At the moment the only way to accurately measure amyloid in a
living person is either via costly positron emission tomography
imaging (PET scan) or by sampling cerebrospinal fluid (CSF)
with a lumbar puncture, or spinal tap.
To surmount this hurdle, Dr. Hodgson and his colleagues in the Gruss Lipper Biophotonics Center at Einstein devised a new fluorescent protein biosensor that, combined
with live - cell
imaging, revealed exactly when and where Rac1 is activated inside cancer cells.
Previously, high - resolution
live imaging has been done
with cells cultured on glass slides, which flattens samples.
These results, along
with imaging technologies that capture pathogens in the
living host, form a «scaffold» for future research into Lyme disease, says Joseph Breen, bacteriology program officer at the National Institute of Allergy and Infectious Diseases, which funded the work.
It also and demonstrates how liver lymphatic
imaging and a novel intervention that seals off the abnormal lymph flow can improve the quality of
life for patients
with this condition.
This is the first time that
imaging with such a thin endoscope has been demonstrated in a
living animal.
«What I like most is the idea of combining information about everyday -
life social networks
with standardized brain
imaging to assess implicit measures of social perception [that are relevant to the real world].»
«
Live imaging of these vessels was crucial to demonstrate their function, and it would not be possible without collaboration
with Tajie Harris,» Kipnis noted.
Using
live imaging in zebrafish to track oligodendrocytes in real time, researchers reporting in the June 24 issue of the Cell Press journal Developmental Cell discovered that individual oligodendrocytes coat neurons
with myelin for only five hours after they are born.
Dr. Taraska's lab studies the structural cell biology of exocytosis and endocytosis
with advanced
imaging methods including
live cell microscopy, superresolution fluorescence, and electron microscopy.
In this role, she works
with many collaborators to facilitate implementing superresolution microscopy into their research programs as well as developing novel techniques for microbial
live cell
imaging.
This is digital fruit fly embryo, reconstructed from
live imaging data recorded
with a SiMView light - sheet microscope (top: dorsal view, bottom: ventral view).
Researchers at the RIKEN Center for
Life Science Technologies, in collaboration
with Osaka City University and Kansai University of Welfare Sciences, have used functional PET
imaging to show that levels of neuroinflammation, or inflammation of the nervous system, are higher in patients
with chronic fatigue syndrome than in healthy people.
The group of
imaging specialists led by Prof. Michael Schäfers, Coordinator of the Cluster of Excellence, labelled the cells thus obtained
with various fluorescent dyes in order to be able to study them in
living organisms — initially
with the optical method of fluorescence reflectance
imaging.
The authors of this study combined
live cell
imaging with electron microscopy to observe Trichoplax feeding behavior at scales ranging from the whole animal to subcellular.
Using a special
imaging technique, Northwestern Medicine scientists have discovered the toxic build - up of amyloid protein is greater on the left side of the brain — the site of language processing — than on the right side in many individuals
living with PPA.
Nagoya, Japan — Dr. Daisuke Maruyama and Professor Tetsuya Higashiyama at the Institute of Transformative Bio-Molecules (WPI - ITbM) of Nagoya University and the JST - ERATO Higashiyama
Live - Holonics Project along with their international team have shown by live - cell imaging techniques that flowering plants, such as Arabidopsis thaliana undergo a cell to cell fusion to prevent the attraction of the second pollen tube after fertilization has occur
Live - Holonics Project along
with their international team have shown by
live - cell imaging techniques that flowering plants, such as Arabidopsis thaliana undergo a cell to cell fusion to prevent the attraction of the second pollen tube after fertilization has occur
live - cell
imaging techniques that flowering plants, such as Arabidopsis thaliana undergo a cell to cell fusion to prevent the attraction of the second pollen tube after fertilization has occurred.
The researchers defined adverse outcomes as the death of the fetus or a
live infant
with severe abnormal clinical or brain
imaging findings.
She was assisted by co-authors Thomas Neuberger, assistant professor of biomedical engineering in Penn State's Huck Institutes of
Life Sciences, working
with the Penn State's High - Field Magnetic Resonance
Imaging Facility, and Kate Anthony, research technician in animal science.
Scientists have pioneered the use of a high - powered
imaging technique to picture in exquisite detail one of the central proteins of
life — a cellular recycling unit
with a role in many diseases.
George and Bohning are among a very select few who have managed to couple TMS
with an up - and - coming technique known as diffusion tensor
imaging (DTI, see «
Live connections»).
In addition to the national awards in France, the Fulbright program has grants to conduct scientific research in three French regions: the Alsace Regional Award (one award), which seeks candidates
with backgrounds in medical
imaging, computer - assisted surgery, and medical robotics; the Aquitaine Regional Awards, which award three grants in 2007 - 08 and emphasize functional genomics, viticulture and wine - related disciplines, biochemistry, optics, lasers, and physics; and the Nord Pas - de-Calais Regional Council Awards (four grants in 2007 - 08), which seek researchers for multidisciplinary projects covering a wide range of
life, physical, and social sciences.
The LOCI lab specializes in developing new
imaging techniques for
living things,
with a special interest in studying cells in their microenvironment rather than in isolation.
«This is a major step beyond what we understood about this moon before, and it demonstrates the kind of deep - dive discoveries we can make
with long -
lived orbiter missions to other planets,» said co-author Carolyn Porco, Cassini
imaging team lead at Space Science Institute, Boulder, Colorado, and visiting scholar at the University of California, Berkeley.
Contact: 508-289-7139;
[email protected] WOODS HOLE, Mass. — Using a simple «mirror trick» and not - so - simple computational analysis, scientists affiliated
with the Marine Biological Laboratory (MBL) have considerably improved the speed, efficiency, and resolution of a light - sheet microscope,
with broad applications for enhanced
imaging of
live cells and embryos.
Using a combination of molecular biology, biochemical and novel multi-dimensional digital
imaging approaches we study in real - time complex multi dimensional signal integration during the interaction of T cells
with live antigen - presenting cells.
Another major investment is Roche's partnership
with the «Netherlands Hub,» an in vivo
imaging consortium of academic and commercial interests driving the science of
imaging technology to characterize the immune response in
living patients versus biopsies and blood samples.
These questions will be addressed by combining unbiased «omics» - approaches (i.e. genomics, transcriptomics, and proteomics) and a targeted genetic analysis
with both superresolution
live - cell
imaging and electron microscopy of nanotube - forming cells.
Working in collaboration
with the Martinos Center for Biomedical
Imaging at Massachusetts General Hospital, Michael S. Placzek, PhD, focuses his research on studying the chemistry and pharmacology of opioids in the
living brain using positron emission tomography (PET).
Visitors can also view
live broadcast feeds of the eclipse from NASA and two of the agency's WB - 57 high - altitude research planes outfitted
with a special high - definition
imaging system developed by Southern Research.
Neuron pathways in the
living human brain shown
with a magnetic resonance
imaging technique.
«We are now able to monitor, in
living synapses, in time - lapse
imaging, changes at the molecular level that underlie the initiation as well as the stabilization of this neuron growth
with learning and memory storage,» he says.
So it seems that,
with this new technology, the entire brain is largely accessible to
imaging now, whereas
with earlier technology you could only get to a shallow layer on the surface of the
living brain.
One of the main tools to gather insights on these questions is microscopy
with a heavy focus on
live imaging.
Combined
with spinning disk confocal, TIRF, FLIM and photomanipulation, Marianas LightSheet is a powerful
live - cell
imaging workstation.
Imaging Real - Time Gene Expression in
Living Systems
with Single - Transcript Resolution: Construct Design and
Imaging System Setup.
Armed
with new
imaging methods such as two - photon microscopy, he and his colleagues are now able to view the ongoing alterations of neural circuitry in
living animals.
Visualization of Endosome Dynamics in
Living Nerve Terminals
with Four - dimensional Fluorescence
Imaging.
Combined
with the high public awareness of the importance of screening, advances in magnetic resonance
imaging (MRI) technology and the availability of preventive drugs targeting estrogen receptors, I believe this test will help to save
lives,» said Dr. Kari Stefansson, M.D., Dr. Med., CEO of deCODE.
She develops techniques and methodologies based on optical
imaging, bio-sensing and single - molecule manipulation
with the aim to monitor the behavior of individual biological molecules and compelxes in vitro and in
live cells.
CODIM systems use standard workflow samples, acquiring images
with the lowest light level, allowing
living cell nanoscale
imaging.
By applying biophysical techniques to elucidate the overall shape of ALC1 and combining these approaches
with cell - based and
live - cell
imaging experiments, the authors of the article in Molecular Cell dissect the molecular mechanisms how the remodeling activity of ALC1 is controlled by its macro domain.
Combined
with spinning confocal, it enables Super Resolution to be achieved at high speed and low photo - toxicity, making it the ideal solution for
live high resoluion cell
imaging.
Now armed
with the human genome and a combination of cutting - edge genetic methods and brain
imaging techniques, lab scientists are now exploring the neural circuitry of
living animals in ways they could likely have never dreamed of even just 20 years ago.