Sentences with phrase «with lower durations»

Bond prices are impacted by interest rate changes — bonds with higher durations carry more risk above and have higher price volatility than bonds with lower durations

Therefore, if you are concerned about price losses on bonds, you may want to invest in bonds with lower durations.

«Emerging markets high - yield bonds are thus an attractive asset class for the long - term, offering a similarly high yield to US high - yield bonds, but with a lower duration and better credit rating.»

With the low duration of its bond holdings, the fund is clearly trying to protect its investors against rising interest rates.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

While shortening duration can help mitigate interest rate risk, another approach to consider is one that balances exposure to the very front end of the curve with exposure to intermediate maturities for additional yield potential and lower volatility, given that rates are likely to rise slowly and stay historically low for the foreseeable future.

Lifetime withdrawal benefit commencement is low, 12 % in the first duration and then falling to the 6 - 7 % range in subsequent years, with an increase after year 10.

Patient funds are those which trade relatively infrequently, i.e., funds with long holding durations or low portfolio turnover.»

According to W. Bradford Wilcox, the director of the National Marriage Project at the University of Virginia, the gender imbalance of the job losses in this recession is particularly noteworthy, and — when combined with the depth and duration of the jobs crisis — poses «a profound challenge to marriage,» especially in lower - income communities.

While all four countries have different durations between 5.24 and 6.47, the U.S. has the shortest duration of them all, with the lowest risk profile and the highest yield.

As there are issues with both money market funds and ultra-short term bond funds, we recommend that you chose a short - term or low - duration bond fund for this purpose.

We are watching all of this play out real - time as fixed - income fund flows are broadly shunning sectors with embedded credit and / or duration risks, in favor of freshly attractive, and lower risk, high - carry assets.

The presumed duration of the whole human development (a few million years) is so trifling compared with the extent of astronomic time, even at the lowest estimate, that the chance of a variation of the solar equilibrium while the anthropogenesis is in process may be ignored.

As four minutes of added time ticked towards the duration, eventual man - of - the - match Quaner would slip at the crucially wrong time to send the ball flying high and wide into the Fantastic Media stand, before Joe Lolley's direct run concluded with Butland easily controlling the midfielder's low - key attempt.

The study concluded, «Higher lactation intensity and longer duration were independently associated with lower two - year incidences of Diabetes Mellitus (DM) after gestational diabetes mellitus (GDM) pregnancy.

The study showed that breastfeeding is associated with about a 10 percent lower risk of several major cardiovascular diseases in later life among Chinese women, and breastfeeding duration seemed to play a role.

I found an online group of exclusively pumping mothers who helped me through all my problems of discomfort, low supply, and with decisions on frequency and duration of pumping.

This can disrupt your baby's sleeping pattern, and may have other unconfirmed effects like possibly having a lower birth weight compared to others with the same gestation duration, etc..

Currently, mothers in Israel pay twice: Once when their babies get unnecessarily formula, which could compromise the baby's health and is associated with lower rates and duration of breastfeeding.

When Mindell and her fellow researchers examined data on babies in Asia who slept alone, the quality and duration of their sleep were just as low as babies who co-slept with parents.

For example, premature babies, low - birth - weight babies, and babies with severe reflux may stay asleep for shorter durations and feed more often.

«Results: Formula use at birth or short breastfeeding duration were significantly associated with low levels of nurturance, high levels of reported anxiety and increased maternal use of Parent - led routines.

Adjustment for family history of asthma, house dust mite allergy, and hay fever did not materially change the effect sizes for the duration of exclusive breastfeeding with upper and lower respiratory tract infections.

Most studies have revealed protective effects of breastfeeding on common infections in the first 8 to12 months of life.8, 27,29,30 One study, which distinguished between infectious diseases until and from the age of 6 months, revealed results similar to those from our study.24 Although the authors used exclusive breastfeeding for 3 months as the reference group, exclusive breastfeeding for 6 months reduced the risk of gastrointestinal tract infections between the ages of 3 and 6 months but not between the ages of 6 and 12 months.24 We can not explain why breastfeeding duration was only associated with lower risks of lower respiratory tract infection from 7 to 12 months.

One of these countries is the UK, which has one of the lowest breastfeeding rates in Europe, 2 with rates conspicuously below those of Scandinavian countries; only 22 % of UK infants receive any breast milk at age 6 months3 compared with 72 % in Sweden.4 Although a number of interventions have been introduced and targets set5 — 8 to increase rates of breastfeeding initiation and duration in the UK, evidence for their effectiveness is limited.

These findings agree with the results of a British retrospective study demonstrating an increased duration of gestation with increasing coital frequency at all gestational ages up through 37 weeks.8 Similarly, low - risk women delivering prematurely in another study were less likely to be sexually active than the full - term controls.10

Duration of breastfeeding was positively associated with performance on the mental and psychomotor scales, but infants who were breastfed short - term and had higher p, p ′ DDE levels in cord serum had the lowest scores on the mental and psychomotor scales.

Table 1 shows clear and highly significant (P <.0001) tendencies for increasing duration of breastfeeding to be associated with higher scores on measures of cognitive ability, teacher ratings of performance, standardized tests of achievement, better grades in School Certificate examinations, and lower percentages of children leaving school without qualifications.

Unfortunately, significant racial / ethnic disparities in breastfeeding initiation and duration exist in the US with black and some Latina women having lower rates of both as compared with white women.

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

Compared with those included in the analysis, mothers of excluded participants were less educated, had lower annual household income, were more likely to be of nonwhite race / ethnicity, and breastfed for a shorter duration.

Stratifying by maternal postpartum fish intake (< 2 vs ≥ 2 servings per week), the relationship between breastfeeding duration and the WRAVMA score at age 3 years seemed stronger in children of women with higher vs lower fish intake (Table 6), but the interaction was not statistically significant (P =.16 for interaction).

Ludvigsson et al (32) examined 8300 infants and demonstrated that the duration of exclusive breast - feeding was not associated with a lower risk of atopic dermatitis, even among infants with a family history of atopy.

The recent NICE evidence into practice briefing on promotion of initiation and duration of breast feeding, 4 however, recommended that education and support should be targeted at women with low incomes to increase rates of exclusive breast feeding.

Instead we found that a shorter duration of breast feeding was associated with lower scores on mental developmental tests both at 13 months and at 5 years of age.

Specifically, limited breastfeeding duration, low breastfeeding self - efficacy, and concerns over breastfeeding were associated with depressive symptomatology.9 — 12,14 In our large sample, women who were depressed were also less likely to continue breastfeeding at 2 months compared with those women without depressive symptoms.

Additionally, the U.S. Nurses» Health Study found only women with a lifetime duration of breastfeeding of 2 years or more had a significantly lower risk of coronary heart disease than those who never breastfed.

Breastfeeding is associated with about 10 % lower maternal risk of several major cardiovascular diseases (CVDs) in later life, and the magnitude of the inverse association was stronger among those with a longer duration of breastfeeding, according to a large, prospective, observational study among Chinese women.

Furthermore, duration and intensity of breastfeeding have also been found to relate to SIDS levels, with greater duration and intensity leading to a lower risk of SIDS [3].

Additional reasons for deciding not to breastfeed can include concern about the quality and quantity of breast milk, and partner and family support, which are common across developed and developing countries.10, 11 Women who decide not to breastfeed are also more likely to have smoked during their pregnancy, be primiparous mothers (i.e., having their first child), and to have a child born low birth weight or with complex health issues such as cystic fibrosis.9, 12 Prenatal and post-natal stressful experiences may also reduce the duration of breastfeeding.13 Finally, several studies suggest that mother's who return to work within the first 6 months postpartum or anticipate an early return to full - time employment, are less likely to breastfeed.

Moreover, although this reduced the power of the multivariate analysis, the increased risk of low MDI and total IQ scores associated with a shorter duration of breast feeding persisted after adjustment for each of the confounders, including the Raven score.

Longer lactation duration for the first child was associated with higher parity (Table 1), as well as lower BMI during follow - up, less family history of hypertension, less frequent smoking, and oral contractive use, higher DASH diet score, more frequent vigorous exercise, and more analgesic use.

This means that the bank will operate as a fund for the duration of this parliament and won't be available to support the introduction of the «green deal» with low cost finance.

While the once - daily dosing, low side - effects profile, and shortened treatment duration of interferon - free direct - acting antivirals are ideal for injection drug users, most trials of these therapies for HCV have excluded persons with recent injection drug use.

Finally, the draft bill includes a new funding programme, the «Descartes Fellowships,» that would reward between 100 and 150 of the best young researchers with approximately 60 % more money than the lowest wage over the award's 5 - year duration.

As expected, the researchers found that the group of participants who had high levels of anti-HA antibodies when enrolled in the trial experienced a significantly lower incidence of mild - to - moderate influenza disease and some reduction in its duration compared with participants with low HA antibody levels.

In a new study of over 7,000 older Chinese women published online today in the journal Rheumatology, breastfeeding — especially for a longer duration — is shown to be associated with a lower risk of rheumatoid arthritis (RA).

POCUS was also associated with high caregiver satisfaction and a significantly lower pain score and procedure duration compared to x-ray.

Further analysis found that the optimal sleep duration with the lowest risk of sickness absence from work was between 7 and 8 hours per night: 7 hours, 38 minutes for women and 7 hours, 46 minutes for men.

A new study suggests that among healthy adults with a habitual sleep duration of at least 6.5 hours, late sleep timing was associated with higher fast food consumption and lower vegetable intake, particularly among men, as well as lower physical activity.