Sentences with phrase «with luminal»

Both of these subtypes are estrogen receptor (ER) positive, with luminal A carrying the most favorable prognosis.

«This opens up the possibility that cancer subtype - specific signaling is driven by STAT3 and that STAT3 inhibitors may be more effective in patients diagnosed with basal - like cancers than in those with luminal cancers,» Horvath said.

Not exact matches

The team also looked at the levels of the TAZ gene in tumors from women with either luminal or basal tumors.

The results suggest a clinical study should be conducted of a STAT3 - inhibiting drug in patients with basal - like and luminal cancers, Horvath said.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

The researcher highlights that «the subtype Epi - Luminal B behaves particularly aggressive form, and is associated with reduced survival of patients.

Intriguingly, luminal breast cancer cells, which are associated with a much better clinical prognosis, carry this gene in a state in which it seems to be permanently shut down.

Patients with basal breast cancer generally have a poorer prognosis than those with the less aggressive luminal - type breast cancer.

In contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, B).

Loss of RUNX1, a key regulator of estrogen receptor - positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

Given MELK is a cell cycle regulated genes, it would be important for the authors to test whether MELK expression levels in luminal and basal cell lines (Figure 4B) is correlated with their doubling time.

Consistent with this observation of MELK overexpression in BBC, we found that MELK expression in breast tumors has a significant inverse correlation with the expression of luminal markers, including estrogen and progesterone receptors (ER, PR)(Figure 2F, Figure 2 — figure supplement 1F).

GALT interacts strictly with gastrointestinal functions in a dynamic manner; for instance, by increasing intestinal permeability in replay to particular stimulations, or orientating the immune response towards luminal content, allowing either tolerance or elimination / degradation of luminal antigens, or sometimes provoking damage to the intestinal mucosa, such as in coeliac disease or food allergy.

The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens

Oscar for Meaning - Making: The Lovely Bones: After a zestful adolescent girl is murdered, she goes to a luminal, in - between place in which she fails to let go and struggles in vain to help her family cope with the loss.