Sentences with phrase «with lysosomes»

«Cells sequester trash in compartments called autophagosomes» Cells follow a set recipe for recycling: First, the autophagosome is formed around the trash, next autophagosomes are transported and merged with lysosomes - another cellular compartment — and finally, the contents are degraded and either secreted or reused by the cell.

After fusion of autophagosomes with lysosomes, the protein content is digested by a variety of proteases, called cathepsins [130].

Autophagy describes how cells replace themselves and their components over time; in scientific language, it is the process whereby cytoplasmic components are isolated from the rest of the cell within autophagosomes, which are then fused with lysosomes and degraded.

Autophagosome sequesters the degradative targets, whose process is followed by fusion with lysosomes for degradation of its contents.

«Cells sequester trash in compartments called autophagosomes» Cells follow a set recipe for recycling: First, the autophagosome is formed around the trash, next autophagosomes are transported and merged with lysosomes — another cellular compartment — and finally, the contents are degraded and either secreted or reused by the cell.

Finally, APs fuse with lysosomes to form autolysosomes (ALs) that digest and release the breakdown products for re-use, much like a recycling plant would repurpose incoming trash.

The accretion of oxidized dopamine didn't just interfere with lysosomes, however.

The virus must then fuse with the lysosome membrane to escape into the host cell's cytoplasm, where it can multiply.

This then fuses with a lysosome, and the contents are recycled.

The autophagosome then fuses with the lysosome / vacuole, releasing a single - membrane bound package that is then degraded by enzymes (left).

The endosomes can then either recycle its contents by bringing it back to the plasma membrane or degrade it by fusing with a lysosome.

Not exact matches

Working with Ana Maria Cuervo, a professor at Albert Einstein College of Medicine, Nixon and co-workers found that presenilin - 1 helps control the acidity of lysosomes.

Patients who have lysosome diseases like mucolipidosis can be treated with enzyme replacement therapy.

These bags fuse with other bags, enzyme - rich lysosomes, which are filled with acids that degrade the contents of the vacuoles.

A lysosome, which is even smaller and faster, would tell you the cytoplasm is actually Jell - O, because they are moving so fast, they are constantly bouncing off these structures and meeting with resistance, like rubber.

When the actin polymerization occurs at one spot on the surface of an autophagosome, which coincides with the location of WHAMM on these organelles, an actin comet tail is formed, and the rapid assembly / disassembly of the actin polymers «pushes» the autophagosome toward the lysosome for final processing.

The virus, with its hitchhiking antibodies still bound to it, then attaches to a cell and enters the lysosome — a membrane - bound structure within the cell that is filled with enzymes for digesting foreign and cellular components.

By using video microscopy with fluorescent tagging of the two organelles, the scientists observed that the mitochondria and lysosomes formed stable contacts inside living human cells.

Northwestern Medicine scientists have discovered that two key cellular structures, called mitochondria and lysosomes, come into direct contact with each other in the cell to regulate their respective functions.

During antibacterial autophagy, the bacteria get tagged with the protein ubiquitin, marking them for destruction by an organelle called the lysosome.

CUET proteins also associate with specific cellular structures that target the whole complex to the cellular waste disposal and recycling station, the lysosome.

The ALS / FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy - lysosome pathway.

LAMP2A: The A variant of lysosome - associated membrane protein 2 is a receptor involved in the cellular maintenance processes of autophagy, but levels decrease with age, and in at least some species this appears to be one of the factors involved in the age - related decline of autophagy.

Indeed, mutations in multiple lysosomal genes result in severe neurodegeneration and it is becoming more clear that lysosomes also play a neuroprotective role in more common neurodegenerative diseases such as Alzheimer's disease that have not traditionally been associated with lysosomal defects.

Selective labeling and monitoring pH changes of lysosomes in living cells with fluorogenic pH sensors.

Since the root of the problem is that the lysosome is unable to break down all of these stubborn waste products, the most direct solution is to supply them with new enzymes that can degrade those wastes.

LysoSENS - I always believe in sole one (might be to hopeful with bacterial enzyme - filled nanorobots clearing lipofuscin) Reversing Heart Disease, not just heart disease, reverting the major age pigment accumulation problem - lipofuscin in lysosomes that is a major cause of aging (by blocking the proteasome, blocking autophagy and mitophagy process (critical for cell survival).

Another possibility is to cause the lysosome to merge with the external membrane and thus expel all material within it to the extracellular environment.

When he moved back to Tokyo in 1977 to the lab of Yasuhiro Anraku, Ohsumi continued with his new study subject, but worked on transport systems that moved small molecules like amino acids and calcium into and out of the yeast version of the lysosome (idiosyncratically known by yeast biologists as the vacuole — which means «empty space»).

These studies revealed that loss of NEU1 activity was associated with a build - up in lysosomes of the amyloid precursor protein (APP), which they identified as a natural target of the enzyme.

In collaboration with Columbia University's David Sulzer, Cuervo presented evidence of altered CMA in Parkinson's disease in 2004, and then in 2010 demonstrated that inefficient cargo loading of proteins into lysosomes could be responsible for the pathogenic accumulation of proteins inside cells of Huntington's patients.

He was awarded the shared Nobel Prize for Physiology or Medicine in 1974, together with Albert Claude and George E. Palade, for describing the structure and function of organelles (lysosomes and peroxisomes) in biological cells.

Here, Cuervo happily remembers trying to avoid studying lysosomes, running a lab by herself as a postdoc when her advisor went blind, and convincing her husband to write a grant on autophagy with her.

The Steffan laboratory is being funded by the Hereditary Disease Foundation to investigate how the Huntingtin protein interacts with the ubiquitin - tagged trash in order to scaffold it to the lysosome for degradation, and to figure out what kinds of trash may be cleaned up by Huntingtin.

In the lipid storage form of lysosomal storage disease I mentioned that dogs and cats can be born with decreased or missing lysosome enzymes that allows them to process fatty substances (lipids).