Sentences with phrase «with major epidemics»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The researchers were surprised with the findings: «This was a major surprise for us — that soybean oil is causing more obesity and diabetes than fructose — especially when you see headlines everyday about the potential role of sugar consumption in the current obesity epidemic.

Some members of the Erie County Legislature and the Comptroller's Office are criticizing County Executive Mark Poloncarz for trying to shell out big bucks on a long list of county programs — including major priorities like the heroin drug epidemic — with some of an $ 18 millions surplus they're not sure exists entirely.

Together with the German Chancellor and the Norwegian Prime Minister, President Mahama will on Saturday host a major side event on Strengthening a healthy future: Resilient Health Systems to fight epidemics and ensure healthy lives, a follow - up to the proposal made by the three world leaders to the UN Secretary General to set up a panel to review the world's response to health crisis.

Segal says that the global rise in sweetener consumption — along with other major shifts in human nutrition — coincided with the dramatic increase in obesity and diabetes epidemics around the world.

This suggests that a greater understanding of the mechanisms that drive inter-pandemic influenza epidemics may increase our capacity to predict the timing of major outbreaks associated with novel pandemic influenza viruses in the future.

Crowley and Canzater identify five critical actions that should be priorities for monitoring HCV: 1) expand and standardize reporting to the CDC, 2) utilize electronic medical records to collect data on HCV cases and the cure cascade, 3) fund epidemiologic research using clinical data sets, 4) integrate improved monitoring of HCV with responses to the opioid epidemic, and 5) establish and monitor HCV elimination plans across major US health systems.

More than two in three adults in the United States are considered overweight or obese, with substantial biomedical and clinical evidence suggesting that chronic overconsumption of a «western diet» — foods consisting high levels of sugars and fats — is a major cause of this epidemic.

«To rid the world of meningitis epidemics altogether, we need to go after all the major strains in one public health vaccine,» noted Adar Poonawalla, CEO and executive director of Serum Institute of India Private Ltd. «We are partnering with PATH on a pentavalent meningitis vaccine — targeting five meningitis strains, A, C, W, X, and Y — and will begin clinical trials this year.»

In the rare chance that an Olympic traveler catches Zika and exports the virus to another country with mosquitoes that could spread it around, Scott Weaver, a leading Zika specialist and the director of the Institute for Human Infections and Immunity at the University of Texas Medical Branch in Galveston, says there's likely little reason for worry: «It is likely that rates of human immunity in many other parts to the world that are permissive for circulation, such as tropical Africa and Asia, are already high enough to preclude major epidemics like we are seeing in the completely naive populations of the Americas.»

While eating fast food is often blamed as a major contributing factor to the rising obesity epidemic, the wrappers and containers the food is served in are manufactured with fattening PFAS.

Along with mTORc - 1, diet induced IGF - 1 IS the major cause of the acne epidemic.

In his book The Cellulite Cure, Dr. Lionel Bissoon asserts that conventional underwear — the kind with elastic around the legs — is a major factor in the modern cellulite epidemic.

We are amidst an epidemic of over-consumption of calories with excessive high - glycemic carbohydrate consumption a major part of this problem coupled with more sedentary lifestyles.

The worldwide zombie epidemic claims four more major cities with these destructive posters for director Marc Forster's thriller.

With the aim of tackling the inactivity epidemic and creating a health conscious mindset throughout the population, the Health education stream will cover a wide range of major topical issues which impact on people's lives, day in day out.

The ACEs study, along with other major epidemiological studies, show that we have a Major Public Health Epidemic that is actually getting relatively little attention in public discourse and has yet to seriously impact pomajor epidemiological studies, show that we have a Major Public Health Epidemic that is actually getting relatively little attention in public discourse and has yet to seriously impact poMajor Public Health Epidemic that is actually getting relatively little attention in public discourse and has yet to seriously impact policy.