«These mechanical vibrations can, in turn, «talk» to liquids within the hollow device and provide optical readout of the mechanical properties,» said Bahl, who is first author of the paper, «Brillouin cavity optomechanics
with microfluidic devices,» published this week in Nature Communications.
The postdoc will work under the joint supervision of Prof. Weitz and Dr. Raoul Rosenthal to pursue research projects on directed evolution of antibodies
with microfluidic systems.
That's what a researcher at Florida Atlantic University is aiming to do
with his microfluidic technology for reproductive medicine.
«
With the microfluidic chip we can also answer, how bacteria communicate with each other, how they respond to stress or whether the relationship of bacterial strains plays a role in adaptation strategies,» says van Nimwegen.
To apply the ink to the leaves, the researchers created a printing mold
with a microfluidic channel.
The principal component of the microbioreactor is a plastic chip
with microfluidic circuits (green), optical sensors (red and blue circles) for monitoring oxygen and acidity, and a filter to retain the cells while the therapeutic protein is extracted (white circle).
While it took years for the original Human Genome Project to analyze a single human genome (some 3 billion DNA base pairs), modern lab equipment
with microfluidic chips can do it in hours.
«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing
with microfluidics, brings new scale to gene expression studies in complex tissues.»
In a paper published in Nature Methods, postdoctoral fellows Naomi Habib, Inbal Avraham - Davidi, and Anindita Basu; core institute members Feng Zhang and Aviv Regev; and their colleagues reveal DroNc - Seq, a single - cell expression profiling technique that merges sNuc - Seq
with microfluidics, allowing massively parallel measurement of gene expression in structurally - complicated tissues.
Life span extension «definitely exists with the classical method, and it definitely does not exist
with the microfluidics method,» Heinemann says.
We can also couple
that with microfluidics to administer neuromodulators, hormones and other molecules and see how site - selective administration of the chemicals modifies neural activity.
Not exact matches
The ease - of - use factor, lack of big needles, and tiny amounts of blood involved mean the company definitely has something in common
with Theranos — Tasso uses
microfluidics to work
with minimal quantities of blood.
If Theranos is the company that has finally come up
with Beebe's «killer application» for
microfluidics, that may explain its reluctance to show the patented details that make its technology unique, even though that rubs scientists the wrong way.
It is only
with recent advances in
microfluidics and labs - on - a-chip that synthesizing and sequencing DNA has become an everyday task,.
The study indicated that the proteins are readily measurable
with standard assays, but the team hopes to develop a
microfluidic chip that can derive reliable readings within just two hours (well within the duration of many emergency room visits).
Prof. Shen and her unit say that, in the future, nanoplasmonic materials may even be integrated
with emerging technologies, such as wireless systems in
microfluidic devices, allowing users to take readings remotely and thereby minimizing the risk of contamination.
Fussenegger's group developed the genetic network; Professor of Biosystems Engineering Andreas Hierlemann and his team tested the acidity sensor
with the aid of
microfluidic platforms; and Jörg Stelling, a professor of computational systems biology, modelled it in order to estimate the dynamics of the insulin production.
On one occasion he had an encouraging meeting
with the hiring manager at a local company working on
microfluidics; when the interviewer learned that Prasher drove a courtesy van, his interest cooled.
Although some of my research focuses on the development of nanoelectronic devices for life science applications (as well as for telecommunications and radio astronomy), most of my research efforts are based on the use of
microfluidic chips (MFCs)
with molecular biology.
Sarah E. Du, Ph.D., co-principal investigator, an assistant professor in FAU's Department of Ocean and Mechanical Engineering, and an expert in the emerging field of
microfluidics, has developed these tiny customized artificial chambers
with embedded micro-electrodes.
The team is also testing the resolution of the
microfluidic system
with other reagents and materials, bringing researchers one step closer to viewing live biological mechanisms in action at the highest levels of resolution possible.
To take an up - close look at the gold nanoparticles in action, the researchers made a vacuum - tight
microfluidic chamber by pressing two silicon - nitride semiconductor chips together
with a 150 - nanometer spacer in between.
Huang teamed up
with other researchers to do
microfluidics experiments, growing bacteria in tiny chambers and tracking individual cells to learn how photosynthetic bacteria grow in light and dark.
Now a team of researchers in China has developed a new
microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood,
with potential applications for cancer screenings and treatment assessments.
«We thought it would be incredibly useful if we could mimic jellyfish and functionalise
microfluidic devices
with long tentacles,» says Karp.
Prakash says that
microfluidics designers currently start from scratch
with each project, but the bubble technology could offer common building blocks for all
microfluidics designs.
Northwestern University professor John A. Rogers is collaborating
with a broad collection of partners including Gatorade, the Seattle Mariners, the U.S. Air Force and Shirley Ryan AbilityLab to bring his wearable
microfluidic sweat analytics system into widespread distribution.
Developed by Assistant Professor Gretchen Mahler and Binghamton biomedical engineering alumna Courtney Sakolish PhD» 16, the reusable, multi-layered and
microfluidic device incorporates a porous growth substrate,
with a physiological fluid flow, and the passive filtration of the capillaries around the end of a kidney, called the glomerulus, where waste is filtered from blood.
Working
with the IIS Applied
Microfluidic Laboratory of Professor Teruo Fujii, they developed a platform to generate a myriad of micrometer - sized droplets containing random concentrations of reagents and then sandwich a single layer of them between glass slides.
On the other side of the membrane, the glucose is mixed
with a fluid and pumped through the
microfluidics chip, while enzymes are added to trigger a reaction.
With this method, they created a three - dimensional array of permeable carbon nanotubes within a
microfluidic device, through which fluid can flow.
Glucolight spares the premature babies blood samples and enables the blood sugar level to be monitored permanently thanks to the sensor's novel measuring technology, which comprises several parts: A microdialysis measuring head, which was developed at the University Hospital Zurich,
with a «smart» membrane developed at Empa; light sources; a pump; and a
microfluidics chip
with a fluorometer, also developed at the University Hospital Zurich.
With the technology on track for commercialization, Rogers» team, including Dr. Roozbeh Ghaffari, the director of translational science at CBIE, is continuing to test the microfluidic devices in scaled studies with an expanding collection of partn
With the technology on track for commercialization, Rogers» team, including Dr. Roozbeh Ghaffari, the director of translational science at CBIE, is continuing to test the
microfluidic devices in scaled studies
with an expanding collection of partn
with an expanding collection of partners.
What's more, Wardle says, a three - dimensional forest of carbon nanotubes would provide much more surface area on which target molecules may interact, compared
with the two - dimensional surfaces in conventional
microfluidics.
«The intimate skin interface created by this wearable, skin - like
microfluidic system enables new measurement capabilities not possible
with the kinds of absorbent pads and sponges currently used in sweat collection,» said John A. Rogers, who led the multi-institution research team that created the «lab on the skin.»
The researchers also used the new technique, called
microfluidic dissection, in which large numbers of yeast are grown in a chamber bathed
with liquid food containing a constant concentration of nutrients.
«Adipose analysis on
microfluidic chips: Platform works
with minute quantities of liquid to grow cells and study their development.»
Using a new technique they call «in - air
microfluidics», University of Twente scientists succeed in printing 3D structures
with living cells.
Such micro-structured surfaces have helped design new surfaces that mimic surfaces found in nature, such as self - cleaning surfaces, reduced - drag surfaces, surfaces capable of transporting liquids in
microfluidic systems, variants
with anti-icing or heat transfer properties, and even surfaces that facilitate oil - water separation.
In collaboration
with colleagues in Belgium, they have developed a more advanced reactor based on highly complex
microfluidic structures.
As part of the HeMiBio (Hepatic
Microfluidic Bioreactor) project, researchers at the Fraunhofer Institute for Cell Therapy and Immunology IZI in Potsdam in collaboration
with partners at the Hebrew University of Jerusalem have developed a microbioreactor in which liver cells can be kept alive and observed for a period of one month.
Using
microfluidic design principles, Liu's group engineered vortices in their device to increase the chance that tumor cells will collide
with the surface of the flow channel.
«The next step will be to track a few patients over the course of their treatment, taking several blood draws to see if the data captured by the
microfluidic device correlates
with the data their medical team is collecting through other methods,» says Liu.
«WPI brings an outstanding theoretical tool that allows us to understand how microscale objects, such as sperm, interact
with their environment; and we are able to design this know - how into real
microfluidic devices, clinically validate what we designed, and experimentally improve it into a real - world application.»
To that end, Ravaux designed a new
microfluidics device that allows him to precisely control the membrane location where a sperm cell fuses
with an egg.
With the three - year grant, Vanapalli and his collaborators Boyd Butler in the Department of Biological Sciences and Everardo Cobos at the Texas Tech University Health Sciences Center, will build
microfluidic devices that mimic blood flow to study how tumor cells move inside capillaries, how they squeeze through tight spaces, whether they are subject to fragmentation and how they become stuck.
The microfabricated chip could be mass produced and integrated easily
with existing
microfluidic systems.
In this work, Stanford researchers designed, fabricated and integrated EPMs
with PDMS
microfluidic chips.
Experimental set - up
with the bacterium Caulobacter crescentus in
microfluidic chips: each chip comprises eight channels,
with a bacterial population growing in each channel.
But
with internal light emitters excited from the bottom surface, the external light never comes in contact
with the sample, so lensing effects are negated, as is the need for
microfluidics.