Sentences with phrase «with microsatellite»

Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.

In all, there were 291 tumors with KRAS, 393 with NRAS, 393 with BRAF, 378 with microsatellite instability, and 533 with consensus molecular subtypes.

Using nuclear haplotypes with microsatellites to study gene flow between recently separated Cichlid species Hey, J., Y. Won, A. Sivasundar, R. Nielsen, et al. 2004.

Not exact matches

The population - based study of 503 people with colon cancer found that 14 percent of Caucasians and 7 percent of African - Americans had a genetic marker called microsatellite instability, or MSI.

By matching microsatellite lengths found in acorns against those of all the adult trees in the stand, Dow was able to identify the father of each acorn with a high degree of certainty — if the father was present in the stand.

In the largest study of its kind to date, researchers used mitochondrial DNA microsatellites from skin samples gathered from more than 3,000 individual humpback whales across the Southern Hemisphere and the Arabian Sea to examine how whale populations are related to one another, a question that is difficult to answer with direct observations of whales in their oceanic environment.

The goal was to see if a mother ship microsatellite could launch smaller daughter ships, with all the satellites capable of sending magnetic field measurements to Earth.

Further investigation into how EWS / FLI associates with GGAA - microsatellites to drive transcription was the subject of a recent study published in Proceedings of the National Academy of Sciences.

The Microsatellite Center is a high - throughput genotyping laboratory dedicated to mapping monogenic and especially polygenic factors with linkage analysis by using fluorescent detection of microsatellites.

Another breakthrough came a few years later with the discovery of «microsatellites», short sequences of two to four nucleotides.

As a young Chinese scientist, I am participating in an exchange program with Germany, having joined the Chinese - German microsatellite genome research project at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin, Germany.

The samples were then analyzed with a technique called polymerase chain reaction (PCR), used to amplify specific nuclear «microsatellites» for statistically measuring gene flow between the different populations and subpopulations located in the western South Atlantic (Breeding Stock A) and the eastern South Atlantic and Indian Ocean populations (Breeding Stocks B and C, and the Arabian Sea humpback whale population, respectively).

With the recent publication of a large data set of 763 microsatellite markers — short stretches of DNA that are repeated in the genome — from 53 populations in the Human Genome Diversity Project, evolutionary geneticists William Amos and Joe Hoffman of the University of Cambridge in the United Kingdom had enough genomic data to test both models.

Here, we used parentage analysis with multilocus microsatellite markers to measure how varying levels of genetic introgression with non-native rainbow trout (Oncorhynchus mykiss) affect reproductive success (number of offspring per adult) of native westslope cutthroat trout (Oncorhynchus clarkii lewisi) in the wild.

High intake of marine ϖ - 3 polyunsaturated fatty acids (PUFAs) is associated with lower risk of microsatellite instable (MSI) colorectal cancers (CRCs) but not microsatellite stable (MSS) CRCs, according to a new study published March 25 in the JNCI: Journal of the National Cancer Institute.

Both development of CRC and microsatellite instability (MSI) are associated with chronic inflammation.

In fact, the Food and Drug Administration's approval of pembrolizumab in May 2017 for adult and pediatric patients with solid tumors and high microsatellite instability, was the first time it had approved a cancer treatment based on a genetic feature rather than the cancer's location of origin.

The FDA approved nivolumab (Opdivo), an anti-PD-1 checkpoint inhibitor, for patients 12 years and older with relapsed colorectal cancer that is characterized by high microsatellite instability (MSI - hi).

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

Using deCODE's national genealogy database, 100 of these patients were found to fall into 39 families, and a genome - wide scan was conducted with 1000 microsatellite markers.

Dr. Eng presented how the Genomic Medicine Institute collaborated with the Digestive Disease Institute and Pathology and Lab Medicine Institute to successfully integrate microsatellite testing and mismatch repair protein immunohistochemistry into pathology routine for all colorectal carcinomas resected on Cleveland Clinic main campus.

Risk of Microsatellite - Unstable Colorectal Cancer Is Associated Jointly with Smoking and Nonsteroidal Anti-inflammatory Drug Use

Microsatellites were interpreted with Data Collection Software version 3.0 and GeneMapper ID version 3.2 (Applied Biosystems).

CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer.

3 ′ - UTR poly (T / U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity.

For the remaining 14 samples, a match was nearly perfect, with only one or two of the microsatellite markers varying, typically by only one repeat unit, as might be expected through microsatellite instability within a pedigree.

The discovery of one of the genes resulted from the analysis of high - density SNP and microsatellite genotyping of more than 900 men with high body - mass index (BMI) and several hundred non-obese relatives and random controls.

No significant differences in genetic diversity were observed among populations by microsatellite markers with HE ranging from 0.597 to 0.612 and low, but significant, genetic differentiation among populations (FST = 0.019, P = 0.001).

SNP haplotypes spanning 3 genes were consistent with autosomal recessive transmission, and microsatellite data showed that only the segment encompassing COLQ was inherited IBD.

However, this node in the microsatellite analysis is not well supported with a bootstrap value of 49.6 %.

Previous estimates using microsatellites and an ultrametric UPGMA bootstrap consensus tree based on (δμ) 2 genetic distances with low support calculated the divergence of southern lineages (excluding San Nicolas) to be 5539 years ago and 12,000 years ago for the island fox lineage as a whole [14].

Interestingly, cats from Flinders and Tasman Islands have close affinity, in terms of microsatellites, with the Cocos Islands.