Sentences with phrase «with microtubules of»

Not exact matches

In case of any doubt, Wired also learned that, while at Harvard graduate school (right before dropping out to join Google) Damore wrote and performed in a skit about «Microtubule Jerking» and the women who helped with it.

«I saw a picture of the C. elegans embryo with the microtubules all lit up,» she says.

Stuart Hameroff, an anesthesiologist who has spent many years studying brain functions, has collaborated with renowned Oxford University polymath Roger Penrose on a model that explains consciousness as the result of quantum processes occurring in tiny structures called microtubules in brain cells.

A group of LMU physicists led by Professor Erwin Frey, in collaboration with Professor Stefan Diez (Technical University of Dresden and Max Planck Institute for Molecular Cell Biology and Genetics, Dresden), has now developed a model in which the motor proteins that are responsible for the transport of cargo along protofilaments also serve to regulate microtubule lengths.

Microtubules are hollow cylinders with walls made up of tubulin proteins — alpha (green) and beta (blue)-- plus EB proteins (orange) that can either stabilize or destabilize the structure of the tubulin proteins.

«Our study shows how EB proteins can either facilitate microtubule assembly by binding to sub-units of the microtubule, essentially holding them together, or else cause a microtubule to disassemble by promoting GTP hydrolysis that destabilizes the microtubule lattice,» says Eva Nogales, a biophysicist with Berkeley Lab's Life Sciences Division who led this research.

The findings suggest that these previously unknown microtubule structures provide a «roadway» for the transport of mitochondria crucial to maintain energy supplies into the synaptic terminals of these highly active neurons associated with vision.

Through a combination of high - resolution cryo - electron microscopy (cryo - EM) and a unique methodology for image analysis, a team of researchers with Berkeley Lab and the University of California (UC) Berkeley has produced an atomic view of microtubules that enabled them to identify the crucial role played by a family of end - binding (EB) proteins in regulating microtubule dynamic instability.

With cryo - EM and their image analysis methodology, they achieved a resolution of 3.5 Angstroms, a record for microtubules.

Like the family of taxanes (of which paclitaxel is a member), epothilones prevent cancer cells from dividing by interfering with tubulin proteins that form the cells» skeletal microtubules.

This particular active material, originally developed at Brandeis University, borrows elements of cellular machinery, with bundles of rod - like microtubules forming the filaments, kinesin motor proteins acting as the engines, and ATP as the fuel.

The researchers used their SDC - PAINT method to visualize the network of cytoskeletal microtubule filaments (green) and their proximity with two additional proteins called TOM20 (red) and HSP60 (blue).

3D CELL DIVISION: The stages of cell division, seen frequently in 2 - dimensions, imaged with the Bessel beam plane illumination: chromosomes appear in orange and microtubules in green.

To do this, they have to keep reorganizing their cytoskeleton, removing pieces from one end of a microtubule and adding them to the front, like a railroad with a limited supply of tracks.

If you imagine the female egg cell (and later, the fertilized egg) as a spherical planet with its own intrinsic biological geography, then certain characteristics of that cell — the location of protein molecules or RNA messages or biochemical traits like pH or even the internal connective structures called microtubules — will be more prominent in certain regions, like one hemisphere as opposed to the other, or near the surface rather than near the core.

In order to segregate chromosomes into the two emerging cells, the spindle itself needs a bipolar structure, and so the microtubules must be sorted to align with the long pole - to - pole axis of the spindle.

The researcher explains that «if the microtubule has traces of tyrosine, the CENP - E carrier rests and doesn't transport any chromosomes from the pole; but should the microtubules have no tyrosine signal, as it happens with the system's main microtubules, the CENP - E tows the chromosomes to the spindle equator.»

The mitotic spindle includes thousands of microtubules, rod - like structures with polarized tips, which biologists term «plus ends» and «minus ends.»

Somehow, the microtubules interact with the nuclear envelope to send a signal to increase mobility of damaged DNA.

Monte Carlo simulations with up to 1,000 blocks, a realistic size for a microtubule, confirmed the results of their calculations with smaller systems, Kolomeisky said.

And here again, that force scales up with the length of overlap between the microtubules.

«One of the most interesting phenomena associated with microtubules is this dynamic instability,» Kolomeisky said.

To figure out how MAPs respond to the movement of the microtubules, the researchers measured the friction generated while each of three MAPs were in contact with moving microtubules.

Microtubules (roads made of proteins) extend throughout a cell for motor proteins (carriers) to deliver neuronal cargo packed with many kinds of materials required for life activity.

For example, the protein PRC1 binds with microtubules, creating bundles of microtubules and cross-links between them.

The atomic structure from the NIH team could be fit into the lower - resolution 3D EM image reconstruction to identify the regions of the protein that interacted with the microtubule surface.

With this new piece in place, the researchers can tackle new aspects of microtubule function and work toward applications in human health.

The evening began with Hancock, accompanying himself on the ukulele, singing «I wish they all could be microtubules» to the tune of the Beach Boys» «I wish they all could be California girls.»

The antibody - drug conjugate consists of an anti — nectin - 4 monoclonal antibody, combined with the microtubule - disrupting agent MMAE.

Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility.

Microtubule - targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.

Nup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK.

Anastasiya Trushko (Howard, MPG)-- «Interaction of XMAP215 with a microtubule plus - end studied with optical tweezers» (2012)

The team was amazed to find a consistent association, throughout cells: the location of PTEN proteins closely coincided with the presence of tiny highways called microtubules that crisscross throughout every cell (image below).

The microscope image of the dorsal closure of a fly embryo shows alter - nating stripes of epithelial cells with aligned microtubule bundles (green) and epithelial cells treated with a microtubule - destroying drug (blue).

DNA was stained with DAPI (chromosomes, blue): Chromosomes interact with microtubules constituting mitotic spindle via kinetochores assembled on centromere region of chromosomes.

Imaging data, combined with the results of genetic experiments, revealed a mechanism by which plants orient microtubule arrays.

It does so by severing the microtubules where they intersect with each other, creating new ends that can regrow and themselves be severed, resulting in a rapid amplification of new microtubules lying in another, more desired, direction.

He received the Award of Excellence of the University of Heidelberg as well as the Otto - Haxel - Prize for his diploma work at the European Molecular Biology Laboratory (EMBL) on the «Analysis of microtubule dynamic instability with light sheet - based microscopy».

Tau is a microtubule - associated protein with an important role in the stabilization of the neuronal cytoskeleton.

These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal neurons; a decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.

a. Normal ciliary axoneme with one central pair of microtubules (arrow) and nine peripheral microtubular doublets (arrow head).

Although the respiratory system signs are usually the most important, several signs related to pathology in other tissues with ciliated epithelia or microtubules can occur, such as otitis media, infertility in males and females, hydrocephalus, and renal fibrosis or dilation of renal tubules.