Sentences with phrase «with model animals»

Not exact matches

PPAR gamma agonists have shown strong potential in animal models related to the various phenotypes associated with X-ALD.

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

As I stated in my original article, prior to conducting experiments with human cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees with reasonable certainty that an embryo is not generated.

[104] In place of WS, animal protectionists hold up their work with sheep producers of Marin County, California as a better coyote management model.

Inside, cages filled with detailed models of extinct animal species thought to be the ancestors of the animals we are familiar with today line both sides of the main floor.

Holiday Magic also includes singing to the animals, a model railroad display, photo opportunities with animals, professional ice - carving demonstrations and a 41 - foot talking tree.

December 9 - 11: Gardens Aglow transforms 100 acres into a twinkling wonderland with holiday displays, family - friendly activities, marshmallow - roasting, live performances, Santa Claus visits, model trains, and baby animals (Sandwich)

You can help teach your child to be gentle by modeling the behavior yourself, by having your child role play with a doll or stuffed animal, and by helping your child to be aware that her movements and tone of voice are just as important as gentle touch.

November 27: Gardens Aglow transforms 100 acres into a twinkling wonderland with holiday displays, family - friendly activities, marshmallow - roasting, live performances, Santa Claus visits, model trains, and baby animals (Sandwich)

Gardens Aglow transforms 100 acres into a winter wonderland with family - friendly activities, marshmallow - roasting, live performances, Santa Claus visits, model trains, and baby animals (Sandwich)

Wooden model of naked prime minister with animal's head follows claims of dining club initiation in book by Lord Ashcroft

«By studying how education changes the brain, we can find out how this uniquely human experience induces change in both brain structure and function — something we can not do with animal models.»

The Nutritional State - structured Model (NSM) by ecologist Justin Yeakel (UC Merced), biologist Chris Kempes (Santa Fe Institute), and physicist Sidney Redner (Santa Fe Institute) incorporates body size and metabolic scaling into an extinction model where «hungry» or «full» animals, great and small, interact and procreate on a landscape with limited resouModel (NSM) by ecologist Justin Yeakel (UC Merced), biologist Chris Kempes (Santa Fe Institute), and physicist Sidney Redner (Santa Fe Institute) incorporates body size and metabolic scaling into an extinction model where «hungry» or «full» animals, great and small, interact and procreate on a landscape with limited resoumodel where «hungry» or «full» animals, great and small, interact and procreate on a landscape with limited resources.

New research from an international group led by Min Zhao, professor of ophthalmology and of dermatology at the University of California, Davis, shows that, in animal models of diabetes, slow healing is associated with weaker electrical currents in wounds.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

The research, published today in Nature Neuroscience, demonstrated that brief treatment with a very low dose of romidepsin, a Food and Drug Administration - approved anti-cancer drug, restored social deficits in animal models of autism in a sustained fashion.

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

«Cerebellar interactions with the frontal cortex in cognitive processes has never been shown before in animal models,» says Parker, UI assistant professor of psychiatry and the first faculty hire of the new Iowa Neuroscience Institute.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

In animal models, the researchers found that using microRNA to disrupt cells in the brain's prefrontal cortex — a region associated with complex planning and decision - making — affected learning and memory later in life.

Senior author Byungkook Lim, an assistant professor in the Neurobiology Section, said the results require much more study and evaluation to be applied to humans with depression, but the new research in animal models provides solid grounding.

The CDC team's work combines «superb conventional epidemiology with a well - characterized animal model,» epidemiologists Barry Bloom and Peter Small write in an accompanying editorial.

The key challenge was to figure out what the right question was, and then to formulate a model that could both answer it theoretically and lead to predictions that would be testable through observations and experiments with real animals.

To find out what impact this might have on a flu epidemic, Earn and his colleagues turned to a 1982 study which showed that ferrets, a common animal model for human flu, produced more seasonal flu virus if their fevers were lowered either with painkillers or by having their fur shaved off.

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

Approach - avoidance conflict is a model used in psychology to test how animals deal with regulating fear and anxiety.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

From here, we'll be optimizing the delivery system, evaluating the approach in more severe models of DMD, and assessing efficiency and safety in larger animals with the eventual goal of getting into clinical trials.»

These tools, coupled with animal models of disease and with the latest methodologies in genomics and proteomics, are leading to vast amounts of information about the nervous system under normal and pathologic conditions.

One 2014 study based on modeling animal movement found that increasing vehicle density on existing roads, rather than adding more roads with lower density, resulted in fewer wildlife fatalities.

Animal models come with some uncertainty, cautions biochemist James Stevens of the Scripps Research Institute in La Jolla, Calif., but he says «it's probably the hemagglutinin switch which is going to be one of the critical events» in a future pandemic.

Researchers performed a meta - analysis of literature examining patients with NASH, and then tested their hypothesis using an animal model, which enabled them to eliminate possible confounders of the clinical data, such as antibiotic exposure and medical comorbidities.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

Weaver studied the animal models for as long as 100 days, and found that the islet clusters transplanted with the hydrogel and VEGF developed many blood vessels and engrafted into their new locations.

«The project's goal is to accelerate the development of technologies for mapping the brain's circuitry in animal models, specifically in the marmoset monkey, whose neural circuits are much closer to human compared with rodent models, and to connect the results to the diagnosis and treatment of human neurological disorders and mental illness.»

McDonald is working with medicinal chemists at Vanderbilt to develop more selective and potent PGD inhibitors for testing in animal models, with the ultimate goal of moving these inhibitors into clinical trials for pancreatic cancer patients.

Because the researchers found that CTLA4Ig was effective in suppressing hepatitis in this study, they suggest that CTLA4Ig should be among the therapeutic options investigated further as a potential therapy for patients with severe acute hepatitis B. To this end, this animal model is useful for virological and immunological analysis of HBV infection.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

We have mouse models for many of these diseases, says Zeng, so we can treat the brains of affected animals with the same dye - and - dice approach.

Typical pain treatment research begins with an animal model — one that uses only male mice.

«Despite the prevalence of abnormal sleep patterns in PD, very few studies to date have outlined sleep disturbances in animal models of PD,» says Sarah M. Rothman, PhD, a researcher with the National Institute on Aging, in Baltimore, MD..

With the advent of new gene editing techniques, some less common animal models such as octopuses may find their way into scientists» toolkits.

Using the freshwater polyp Hydra as a model organism, the Kiel - based researchers and their international colleagues investigated how the simple nervous system of these animals interacts with the microbiome.

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

Suzuki hopes to experiment next with animals that model muscular dystrophy and amyotrophic lateral sclerosis.

The potential strategy — which targets metabolic pathways that are active only during intestinal inflammation — prevented or reduced inflammation in a mouse model of colitis while exerting no obvious effect in control animals with healthy, balanced bacterial populations, said Dr. Sebastian Winter, Assistant Professor of Microbiology and co-corresponding author of the study published online today in Nature.

Herzberg said his stories dealt «with obviousness that is not obvious... the stethoscope as the eternal symbol of doctors, mice as our best animal model, eels as simple, almost boring, river fishes.

Chief among the criticisms were the animal's hindlimbs, significantly smaller compared with other large predatory dinosaurs, as well as other researchers» theoretical Spinosaurus models.