Sentences with phrase «with multiple alleles»

Selection in finite populations with multiple alleles.

Not exact matches

The queen bee, who, in the course of their mating flight, mate with different drones multiple times, passes on to fertilized eggs a random combinations of two csd copies, so - called alleles.

However, prevailing GWA data analysis methods are focusing on the association of individual SNP alleles with a complex disease, although multiple alleles are involved by definition.

The WGS data was included 582 individuals from 111 multiplex AD families of European or Caribbean Hispanic ancestry, favoring families with multiple cases across generations excluding families with higher frequency of the APOE ε4 allele.

They applied a strategy for seraching genes with multiple rare (minor allele frequency < 0.001) variants in cases but not in controls with a potentially damaging effect.

These GEMM - ESCs, with often multiple modified alleles, form the basis for further genetic engineering either by Flp - recombinase mediated integration, gene targeting or Crispr / Cas9 to allow for the evaluation of altered target gene expression in a spontaneous tumor model.

«What was somewhat surprising is that we observe multiple different Neanderthal alleles contributing to skin and hair tones,» Janet Kelso, a computational biologist who co-authored the study with her colleague Michael Dannemann, told Seeker.

Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles.

The large sample size combined with sensitive sequencing techniques that detected even rare alleles and infections by multiple parasites enabled researchers to find an allele - specific response that smaller studies had missed.

The affected dogs (A) are homozygous for the dodecamer repeat expansion mutation with multiple dodecamer repeats, carrier (C) dogs have the normal and mutated allele and clear dogs (WT) have three copies of the repeat [8]

Second, we sought to determine whether the frequency of S allele carriers predicts cultural individualism and collectivism by conducting a multiple regression analysis with individualism — collectivism as the criterion variable and frequency of S allele carriers, as well as four other economic and health factors previously associated with individualism — collectivism including GDP per capita, inequity in the distribution of wealth (Gini index) as well as historical and contemporary pathogen prevalence as predictor variables (Fincher et al. 2008).