Sentences with phrase «with multiple phases»

Not exact matches

BIIB098: MRI and relapse results from the phase 3 EVOLVE - MS - 1 study in patients with relapsing and remitting multiple sclerosis were presented at the 70th annual meeting of the American Academy of Neurology (AAN).

What I have learned from many years of working with tech - enabled growth companies; on both sides of mergers and acquisitions; and angel, private equity and venture capital investments, is that accretion of IP value is the key element to supporting overall enterprise value — representing scalability in phases of rapid growth and supporting attractive multiples during the fundraising and exit phases.

The company's leading program, a differentiated PPAR gamma agonist (MIN - 102) that has multiple CNS indications, has successfully completed a phase 1 clinical trial and is ready to move into a phase 2/3 study with adult AMN patients.

Product Detail: In Phase II, a company's product is sent through an exhaustive review process with investors basically attempting to poke holes in the company's product thesis from multiple angles.

Coping with two or more infants is certainly one of the most challenging phases of parenting multiples.

I give props to all you mama's with multiple children and going through the baby phase.

For customers seeing higher than average increases, our Institutional Licensing team will work closely with them to establish transition plans, phasing in our new rates over multiple years.

Watercress extract taken multiple times a day significantly inhibits the activation of a tobacco - derived carcinogen in cigarette smokers, researchers at the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter, demonstrated in a phase II clinical trial presented today at the American Association for Cancer Research (AACR) Annual Meeting in New Orleans.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

«Multiple myeloma patient study shows promise for natural killer cells: Phase I study included combination with high - dose chemotherapy and stem cell transplantation.»

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

Poseida Announces Initial Phase 1 Data for P - BCMA - 101 CAR - T Stem Cell Memory Product in Patients with Relapsed / Refractory Multiple Myeloma

on Poseida Announces Initial Phase 1 Data for P - BCMA - 101 CAR - T Stem Cell Memory Product in Patients with Relapsed / Refractory Multiple Myeloma

A Phase 1, First - in - Man, Multicenter, Open - Label, Two Part Dose - Escalation and Cohort Expansion Study of Single - Agent GBR 1342 in Subjects with Previously Treated Multiple Myeloma

In the interim analysis of this ongoing multiple - dose Phase 1b / 2a study, children with Type II or Type III SMA were dosed intrathecally with 3 mg, 6 mg or 9 mg of ISIS - SMNRx.

ISIS - SMNRx is also being evaluated in an open - label, multiple - dose, dose - escalation Phase 2 study in infants with Type I SMA.

Once we evaluate ISIS - SMNRx as a single - dose in children with SMA, we will move to multiple - doses in our Phase 1 studies and eventually evaluate the drug in Phase 2 studies in children with SMA, including infants with Type I SMA.»

ARRY - 520, a novel selective kinesin spindle protein (KSP) inhibitor showed promising clinical activity both alone and combined with low - dose dexamethasone in a phase II clinical trial in patients with relapsed and refractory multiple myeloma.

5a: Jankovic J, Goodman I, Safirstein B, Schenk D, Kinney G, Koller M, Ness DK, Griffith S, Grundman M, Soto J, Ostrowitzki S, Boess F, Martin - Facklam M, Quinn J, Isaacson S, Jennings D, Omidvar O, Ellenbogen A. Results From a Phase 1b multiple ascending - dose study of PRX002, an anti — alpha - synuclein monoclonal antibody, in patients with Parkinson's disease [abstract].

The combination of pomalidomide plus low - dose dexamethasone showed efficacy with high rates of disease control in relapsed or refractory multiple myeloma patients with severe renal impairment, according to the results of a phase II study.

Based on those previous signals, Somaiah and colleagues conducted a phase II study testing the anti — PDL - 1 agent durvalumab in combination with the anti — CTLA - 4 agent tremelimumab in multiple sarcoma subtypes.

5: Jankovic J, Goodman I, Safirstein B, Schenk D, Kinney GG, Koller M, Ness DK, Griffith SG, Grundman M, Soto J, Ostrowitzki S, Boess FG, Martin - Facklam M, Quinn JF, Isaacson SH, Jennings D, Omidvar O, Ellenbogen A. Results from a Phase 1b multiple ascending - dose study of PRX002, an anti-alpha-synuclein monoclonal antibody, in patients with Parkinson's disease.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

A Phase I study in AD patients demonstrated good safety and tolerability of multiple injections of aggregated Abeta42 (AN1792) with QS - 21 as adjuvant.

The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.

During the pilot phase, the Project is analysing Illumina short - read sequence data on 2,512 samples from multiple locations in Africa and Asia, together with laboratory samples for benchmarking and methods development.

A combination of the indoleamine 2,3 - dioxygenase 1 (IDO1) inhibitor epacadostat with the anti — programmed death ligand 1 (PD - L1) antibody durvalumab was well tolerated in a phase I trial of patients with multiple solid tumor types.

All of the trying - to - conceive women we talk to are far more interesting than textbooks... some women have multiple Cue Peaks, some women have «unexpected» ups and downs in their readings, some women end up with both a pink and purple box, and some women have vaginal readings that drop during the luteal phase.

Affleck and Pike are tasked with playing multiple versions of the same characters, and they sell each phase — from deliberately awful rom - com pretensions to claws out bitterness.

The other two phases, as said, are the use of these clues and materials found on the scene to access better and more complex solutions in the dialogue, and then the dialogue itself where you are required to save the target no matter what, with multiple endings which determine whether you'll sacrifice yourself, for example, or throw the both of you from the building.

Looking something like Johnny Cash crossed with Tom Waits, Cox has multiple addictions, wives and musical phases.

Generally, a «closed» school is one which is disbanded and replaced by another school in the same building, with different leadership, etc (or by multiple smaller schools, or several closed schools may be replaced by a single larger one)-- the phase «shutting down the school» is very misleading in this context.

It was through working with Xydias on the belly - tank restoration the next phase of Chapouris» life would begin with the re-creation of the SO - CAL Speed Shop (located in Pomona, California), which included partnerships with GM on their Bonneville salt flat racers as well as multiple SO - CAL Shops franchises located across the United States.

Advance payments may be split into multiple phases, with a payment for signing and further payments for reaching milestones in completing the contract requirements.

All throughout this legal battle, Apple has fought Judge Denise Cote on nearly every ruling, and have filed multiple motions and appeals; at one point, Apple was back in court for directly refusing to work with the court - appointed monitor that Cote ordered as a result of ruling against Apple in the initial phase.

Lump sum payments are only used for immediate annuities because multiple payments are not practical with no accumulation phase.

These funds represent the next phase of sector investing: using a factors - based approach to target companies with the potential to outperform their broader respective sectors over multiple market cycles.

In all three cases, once the AGI income threshold is reached, the marginal tax rate increases to recognize not only the rising tax brackets, but the surtaxes for Pease and PEP on top (and the cumulative impact of PEP given multiple family members with simultaneous exemptions phasing out).

«Our Asian development strategy is now entering an exciting new phase, with multiple new hotels and brand concepts set to be launched in the coming months and years.

Bahrain has launched the fourth phase of its new visa policy with the announcement of a new single entry visa and one - year multiple re-entry e-visa.

I am acting with the understanding that one big hit title can change multiple phases of a situation in the entertainment business, and I feel that finding such one big hit is my basic job.»

Set across five decks of a massive spaceship, robot opponents slash, shoot, launch missiles from their backs, fire screen sweeping lasers and create smaller enemies to attack, while the giant enemy bosses fight with everything they've got across multiple phases.

Each boss has multiple phases to overcome, with flag points indicating progress upon death in order to goad you into having one more turn, is genius design.

What I am saying is that it makes no sense at all to hand - wave at the effects of uncontrolled volcanic eruptions as «absolute proof» that geoengineering schemes «can work», while promoting a gradual 50 - year phaseout of GHG emissions (which is too slow to have any hope of preventing catastrophic outcomes) as «logical» (whatever that means) and ignoring the multiple studies that show we can easily phase out emissions in a fraction of that time with the proven technologies that are already at hand.

I just wonder if coral bleaching has been mostly correlated with warming events because over the last multiple decades there have been mostly warming events (due to positive phases of ocean cycles).

This cooperation includes technical and policy exchanges on the development of fuel efficiency standards for trucks and buses, continued progress towards implementation of CCUS projects with the selection of a project site in China as the large - scale CCUS demonstration project announced last November, cooperation on reducing HFCs, including private sector commitments to promote climate - friendly alternatives to HFCs, and continued support for phasing down HFCs through the Montreal Protocol, and additional cooperation on direct mitigation efforts across multiple other sectors.

We have a chaotic system with multiple attractors and, Tomas has argued, an almost infinite phase space.

Mishchenko, M.I., and A. Macke, 1997: Asymmetry parameters of the phase function for isolated and densely packed spherical particles with multiple internal inclusions in the geometric optics limit.

During Phase II, testimony will be heard from live witnesses representing stakeholders with interest in multiple sectors of activity, such as Indigenous communities and interest groups.

While a full enterprise implementation may take multiple months, the customer often sees savings and value in as little as 2 months with a phased approach.