Sentences with phrase «with multiple tumors»

Those with the greatest risk for recurrence are those with large, high grade (II & III), or those with multiple tumors.

Cases with multiple tumors are uniformly fatal with involvement of many organs.

The disease itself, with its multiple tumors, suggests the handiwork of such a gene gone awry.

Not exact matches

The indication now covers patients with bone metastases from solid tumors and those with multiple myeloma.

In December, Pope Francis announced that Mother Teresa would be declared a saint after recognizing a second miracle attributed to her: the healing of a Brazilian man with multiple brain tumors after loved ones prayed to her.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

Comparing the metastasized tumors with the original breast tumors, the researchers were surprised to learn that multiple, slightly genetically different cells from the original site had broken away together and established the new tumors.

«Thanks to a deeper understanding of cancer biology, we have a potential new targeted therapy for multiple myeloma, and can better tailor treatment for kids with Wilms tumor.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

These drugs are also frequently used to manage central nervous system (CNS) disorders associated with a pathologically permeable BBB, such as with brain tumors and multiple sclerosis.

If metastatic cancers are most often made up of cells with different genetic drivers, perhaps researchers should be targeting the primary tumor with multiple drugs to contain the cancer.

«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medicalmultiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard MedicalMultiple Myeloma Center, and the R.J. Corman professor at Harvard Medical School.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

Both Tsigelny and Kurzrock agreed that this finding is an excellent example of the power of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different genes involved in cancer.

«Therapy shrinks tumors in patients with multiple myeloma.»

«Having these personalized laboratory models, which we can make in a matter of weeks, will let us test multiple different drugs on the tumor and help us bring precision medicine to individuals with bladder cancer.»

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

«Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem - cell - loaded oncolytic viruses that specifically kill dividing tumor cells.»

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Yongwon Choi, with Ralph Steinman and others, identifies a new tumor necrosis factor family member TRANCE (later called RANKL), [i] and subsequently demonstrates its role in the immune and bone system, and also in bone - residing cancers such as multiple myelomas.

In conclusion, PPAM seems to inhibit TICs / CSCs of various tumor entities via multiple mechanisms with high activity.

EOS200271 has demonstrated anti-tumor activity in multiple preclinical tumor models in monotherapy and in combination with immune checkpoint inhibitors.

Many people suffering with cancer and diseases associated with immune dysfunction, such as lymphoma, leukemia, multiple myeloma, solid tumors, recurrent infections, neurodegenerative disorders and other chronic diseases, have turned to the Maharaj Institute in the hope of finding a more favorable prognosis and better quality of life.

For this compilation, I've emphasized publications in which whole - genome or exome sequencing was employed to multiple tumors or cancer cell lines, with the goal of identifying significantly altered genes or pathways in malignant cells.

These GEMM - ESCs, with often multiple modified alleles, form the basis for further genetic engineering either by Flp - recombinase mediated integration, gene targeting or Crispr / Cas9 to allow for the evaluation of altered target gene expression in a spontaneous tumor model.

To date, they have shown that BiTEs are: (1) highly - specific molecules that greatly reduce the risk of toxicity; (2) have the ability to penetrate the blood - brain barrier and accumulate in intracerebral tumors; and (3) may potentially overcome multiple mechanisms of immunosuppression present in patients with glioblastoma.

Although the differing effects of hypoxia reported here are in conflict with previously published data, where no contrasting effect was seen (18 — 20), our data was produced using 13 primary breast cancer samples, as well as established cell lines, and the opposing effects in hormone receptor — positive and negative tumors, measured using multiple in vitro and in vivo CSC assays, were consistent in all cases.

A combination of the indoleamine 2,3 - dioxygenase 1 (IDO1) inhibitor epacadostat with the anti — programmed death ligand 1 (PD - L1) antibody durvalumab was well tolerated in a phase I trial of patients with multiple solid tumor types.

I am a motivated medical writer with over 12 years of research experience in multiple labs, working on a variety of biochemical topics, centering on the role of kinases in hypertension, angiogenesis and tumor development.

Multiple other studies with mice have shown that dietary flaxseed works with tamoxifen to inhibit breast tumor growth.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

The standard for many years has been administration of multiple small doses of radiation with the goal of eradicating the tumor.

In cases of multiple myeloma with bone involvement, blood tests can help to indicate the nature of the tumor.

Multiple tumors are uniformly fatal with involvement of many organs.

LEUKOCELL 2 is a multiple viral antigen vaccine for vaccination of healthy cats 9 weeks of age or older as an aid in preventing persistent viremia, lymphoid tumors caused by feline leukemia virus (FeLV) and diseases associated with FeLV infection.

Approximately 20 % of cats with mass cell tumors will have multiple growths and about 25 % will have some ulceration of the masses present.

Four out of five dogs with lymphoma or lymphosarcoma have tumors that start in multiple places (multicentric).

Also, multiple tumor types might be present, and you can make the wrong interpretation with just this test.

Worked with multiple partners to establish a tumor tissue bank that houses samples of the most common canine cancers, which will help scientists study cancer and potential treatments

10 % of patients diagnosed with SCC will develop multiple tumors affecting two or more digits (Belluco S et al Vet Pathol 2013; Henry CJ JVIM 2005).

Her years of constant reproduction have also left her with multiple large mammary tumors.

Half of the dogs with mammary gland tumors will have multiple tumors.

With this panel, we can identify, or rule out, multiple diseases inherited in Labradors, such as hip dysplasia, ruptured anterior (cranial) cruciate ligament, mast cell tumor, T and B - cell lymphoma, posterior polar cataracts, liver disease, laryngeal paralysis, degenerative myelopathy, epilepsy, tricuspid valve dysplasia and obesity.

Prognosis of patients with this disease depends on multiple factors, the most commonly cited including: presence of metastasis (negative), elevated alkaline phosphatase (negative), large tumor size (negative), humerus location (negative), treatment chosen (dogs receiving amputation and chemotherapy have improved survival times over dogs receiving amputation alone) 1.

The biggest thing is making sure you can qualify for life insurance with SBLI, so lets cover (in general) what SBLI will and won't insure: SBLI Underwriting Uninsurable medical scenarios with SBLI: • Aids / HIV + status • ALS (Amyotrophic Lateral Sclerosis) • Alzheimer's disease or dementia or significant cognitive impairments related to functionality • Cancer diagnosis within last 2 years • Chronic pain treatment, severe, receiving disability, narcotic use • Cirrhosis of the Liver • Congestive heart Failure • COPD / Emphysema or chronic bronchitis - Severe or with current nicotine use • Cystic Fibrosis • Defibrillator use • Depression, severe, recurrent or with multiple in - patient hospitalization history • Diabetes with co-morbidities that include significant cardiac disease, or impairment of renal function or mobility • Heart / Cardiac Disease - multiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceemultiple in - patient hospitalization history • Diabetes with co-morbidities that include significant cardiac disease, or impairment of renal function or mobility • Heart / Cardiac Disease - multiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceemultiple vessels diagnosed within 2 years or any past history with current nicotine use • Muscular Dystrophy • Multiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceeMultiple Sclerosis, if symptoms progressing • Organ Transplants, in most scenarios • Quadriplegia • Pulmonary hypertension • Renal failure, Renal insufficiency - severe • Stroke within 1 year • Suicide attempt within 5 years • Surgical repair of heart valves, aneurysms, intracranial tumors, major organs within six months, including gastric bypass Uninsurable non-medical scenarios: • Marijuana use, 4 or more times weekly • Substance abuse / misuse within last 5 years • Criminal activity - any history within the last 10 years • DUI, more than 2 or under age 25 if within 1 year • Unemployed (other than homemakers or retired) with minimal household income or dependent on SSI / disability benefits • Bankruptcy filing within 2 years • Liens / Judgements - outstanding activity that exceeds $ 50K