I like the inositol supplement Ovasitol because it is a cost - effective way to supplement
with both myo - inositol and D - chiro - inositol.
That's why it's now recommended that women with PCOS supplement
with both myo and DCI in a 40:1 ratio, that mimics the body's natural physiological levels.
Combining treatment
with myo - inositol and D - chiro - inositol (40:1) is effective in restoring ovary function and metabolic balance in PCOS patients.
Both MYO and DCI have been shown to improve metabolic factors in PCOS,
with MYO showing the most promise.
Both MYO and DCI have been studied in infertile women with PCOS,
with MYO showing the most promise in improving ovulation and egg quality.
27Minozzi, M.; D'Andrea, G.; Unfer, V. Treatment of hirsutism
with myo - inositol: a prospective clinical study.
The combined therapy
with myo - inositol and D - chiro - inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo - inositol supplementation alone.
Ovulation was restored in 65 % of women treated
with MYO vs. 50 % in the metformin group.
I will say that the majority of patients I work with have seen better menstrual cycles and ovulation
with myo - inositol.
Assessment of the modification of the clinical, endocrinal and metabolical profile of patients with PCOS syndrome treated
with myo - inositol].
Not exact matches
Caesar Asparagus was a springy feeling side that was just so easy: roasted asparagus,
MYO caesar dressing, and top
with some hard boiled eggs and plenty of salt & pepper!
Gerli, Papaleo, Ferrari, and DiRenzo (2007) found that
myo - inositol helped women
with PCOS who were not ovulating to begin ovulating again (in women
with a BMI under 37).
Another study (Artini, DiBerardino, Papini, Genazzani, Simi, Ruggiero, & Cela, 2013) offered similar positive results on ovarian function, as well as improvement of insulin sensitivity in women
with PCOS who were taking
myo - inositol (in this study, the dosage was only 2g per day).
Randomized, double blind placebo - controlled trial: Effects of
myo - inositol on ovarian function and metabolic factors in women
with PCOS.
It is wise to find a healthcare practitioner you trust and discuss options like
myo - inositol
with him or her.
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS,
myo - inositol -1-phosphate synthase; mLST8, mammalian lethal
with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting
We treat many people
with complex chronic pain problems and the
MYO Buddy Pro Massager plays an essential role in reducing allodynia and hyperalgesia in our toughest cases.
If you are planning on trying Pregnitude, you may want to start out
with one packet per day (2 g
MYO) for a week to see how you respond.
You should use caution when combining high doses of
MYO with St. John's Wort or other herbal products or medications that may reduce blood sugar (such as metformin, byetta).
In addition to lowering glucose and insulin levels,
MYO has been shown to improve lipid and androgen levels, blood pressure and egg quality in women
with PCOS.
Metabolic and hormonal effects of
myo - inositol in women
with polycystic ovary syndrome: a double - blind trial.
Don't let the name of this product fool you: Pregnitude is a
myo - inositol (MYO) supplement for all women with PCOS, not just those looking to get pregna
myo - inositol (
MYO) supplement for all women with PCOS, not just those looking to get pregna
MYO) supplement for all women
with PCOS, not just those looking to get pregnant.
High doses of
MYO may have additive effects when taken concurrently
with selective serotonin reuptake inhibitor (SSRI) and selective serotonin norepinephrine reuptake inhibitor (SNRI) antidepressant medications.
One study showed the prevalence of GDM in the
MYO group was 17.4 % compared
with 54 % in the control group.
Lean women
with PCOS or those that don't have severe insulin resistance may not need the full dose of
MYO at 4 grams / day.
In this direct comparison that included patients both
with and without insulin resistance,
myo - inositol outperformed metformin when it came to reducing testosterone levels, hirsutism, and markers of inflammation (Jamilian et al. 201719).
These researchers also point out that based on the results of lab studies looking at how
myo - inositol and D - chiro inositol ratios are balanced in the ovary tissue of women
with PCOS (Heimark et al. 201410), it's possible that using an overwhelming amount of
myo - inositol over D - chiro - inositol in a 40:1 ratio could «exert paradoxical effects».
It's recommended that women
with PCOS take a combined amount of
MYO (2 - 4 grams) and DCI (50 - 100 mg) in a physiologic ratio of 40:1.
Angela Grassi, MS, RDN, registered dietitian and founder of the PCOS Nutrition Center, used a
MYO supplement for over a year and blogged about her positive experience
with it.
Studies have shown that
myo - inositol can improve insulin and glucose levels in women
with PCOS.
However, when
MYO is combined
with DCI in an optimal ratio, the best results are seen.
Randomized, double blind placebo - controlled trial: effects of
myo - inositol on ovarian function and metabolic factors in women
with PCOS.Europ rev med pharm sci.
What this tells us is that
myo - inositol is fairly effective at reducing acne, but it still doesn't work for everyone
with PCOS.
In a double - blind placebo trial, Costantino et al showed that
MYO (4 g / day) decreased insulin, triglycerides, testosterone, and blood pressure in women
with PCOS.
In a study of overweight women
with PCOS that were given
myo - inositol + folic acid during IVF, 32 % of women had a successful pregnancy within the 12 month study period, compared to just 12 % of women who only took a straight folic acid supplement without the inositol (Artini et al. 201315).
In a recent study of IUI patients
with PCOS, pregnancy rates were improved by approximately 50 % (regardless of whether or not they had insulin resistance) after taking
myo - inositol for just 3 months beforehand (Ozay et al. 201716).
The first thing worth keeping in mind is that if you're only (or mostly) interested in taking inositol supplements to help
with fertility, you may be just as well off taking a straight
myo - inositol supplement on its own, rather than buying the more expensive 40:1 combination products.
Follicles
with high quality oocytes have a higher concentration of
MYO.
Venturella et al showed that 2 g / day of
MYO for six months resulted in significant weight loss and improved HDL and LDL levels.48
MYO at 1,200 mg / day for 12 weeks significantly decreased androgens and insulin in non-obese women
with PCOS.
The take home from this is that if you're being prescribed recombinant follicle stimulating hormone (r - FSH) as part of an ovulation induction cycle (either
with IVF or IUI), then make sure you're fertility doctor also puts you on
myo - inositol.
One - year effects of
myo - inositol supplementation in postmenopausal women
with metabolic syndrome.
Randomized, double blind placebo - controlled trial: effects of
myo - inositol on ovarian function and metabolic factors in women
with PCOS.
In addition to CoQ10, women who are older may also be interested in
myo - inositol and NAC, which have also been shown in studies to improve egg quality in women
with PCOS.
Comparison between effects of
myo - inositol and D - chiro - inositol on ovarian function and metabolic factors in women
with PCOS.
MYO has been well documented to be superior to DCI in improving insulin resistance, egg quality and reducing the risk for gestational diabetes in women
with PCOS.
At the time of writing, there were two randomized controlled trials that experts use to demonstrate the efficacy of
myo - inositol supplements for reducing unwanted hair growth in women
with PCOS.
In my view, if you're trying to conceive, then it's well worth giving
myo - inositol a try before messing
with metformin.
It's been noticed though that although
myo - inositol is effective in improving insulin sensitivity and most hormonal parameters in overweight or obese PCOS patients, not all obese women see an improvement in metabolic health
with this supplement — even when they lose weight.
Ovasitol is a unique supplement for any woman
with PCOS that combines
myo - and d - chiro - inositol in the body's naturally occurring ratio of 40 to 1.
One group received 2g of
MYO twice daily and a second group
with.6 g of DCI twice daily.