Sentences with phrase «with myofibroblasts»
Not exact matches
The ligands also interfered with other aspects of TED tissue remodeling including collagen production, filament formation, and myofibroblast contraction.
https://www.sciencedaily.com/
«Under normal circumstances, myofibroblasts stimulate wound healing, but when there's an ongoing injury to an organ (e.g., the liver of a hepatitis C patient, the heart of a patient with high blood pressure, or the kidney of a patient with diabetes) these proteins clog up normal functioning,» said Humphreys, a Harvard Medical School associate professor at Brigham and Women's Hospital, who leads the Harvard Stem Cell Institute Kidney Program.
The cardiomyocytes don't proliferate, but the myofibroblasts keep dividing, gradually replacing healthy tissue with fiber - stiffened (fibrotic) tissue.
But heart cells never truly regenerate in the damaged tissue, and myofibroblasts compensate for their absence by forming a stiff, collagenous scar that interferes with the heart's ability to maintain stable heart rhythms and to expand and contract forcefully to pump blood.
The resulting diffuse invasion of myofibroblasts also interferes with the electrical and mechanical functions of the tissue, and can lead to heart failure.
Although myofibroblasts expressing CXCL12 are associated with the presence of axillary metastases in HER2 breast cancers (BC), the therapeutic interest of targeting CXCR4 / CXCL12 axis in the different BC subtypes remains unclear.
As a proof of principle, we demonstrated correlation of the high - risk genotype at the statistically most strongly associated variant with decreased secretion of the soluble WNT - antagonist SFRP4, in surgical specimen - derived DD myofibroblasts.