Sentences with phrase «with nearby gene»

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

Not exact matches

Further, investigation of these CpG associations revealed nearby genes whose RNA expression was altered in brain samples with Alzheimer's disease: ANK1, CDH23, DIP2A, RHBDF2, RPL13, RNF34, SERPINF1 and SERPINF2.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

In the illustration, each tissue type is followed by the number of genes whose level of activity is controlled by nearby genes on the same chromosome (cis); those whose activity is associated with genes on other chromosomes (trans); and the number of tissue samples studied.

The team eliminated three of the four known starch synthases by inserting backward copies of the genes for each one into the potato genome, which, through an unknown mechanism, interferes with the translation of the nearby normal gene.

With the statistical power of 2,000 samples (half in a discovery set, half in a validation set), they were able to search for both cis - regulatory (variants affecting nearby genes) and trans - regulatory (variants affecting distant genes) relationships.

With the encouragement of an early mentor, he volunteered at a nearby gene therapy lab through an after - school program for gifted students.

Then p300 modifies nearby chromatin with a chemical tag called acetylation, somehow releasing the inhibitory chromatin structure to activate a gene.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.

I have a HUGE long list of «happy things» so lets get going on some of them... * hubby brings me a glass of cold OJ every morning * a daughter than lives nearby * creative genes from my father * hubby is employed * we do NOT have the swine flu * completing a very long «to do» list of phone calls and paperwork * American Idol * Dancing With the Stars * opportunities to win goodies on blogs