Sentences with phrase «with normal cell functions»

Cancer cells are unlike any other cell in the body and they act totally out of line with normal cell functions.

Not exact matches

With microRNA - 210 in check, cells regain their normal function and cancer can not grow.

The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.

A virus works with the cell machinery, so it's hard to come up with a drug that doesn't interfere with the cell's normal function.

«It is currently impractical to directly restore Apc function in patients with colorectal cancer, and past evidence suggests that completely blocking Wnt signaling would likely be severely toxic to normal intestinal cells,» Lowe says.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

Again, the liver cells with suppressed ATPIF1 function dealt better with mitochondrial dysfunction than liver cells with normal ATPIF1 activity.

«In these diseases of mitochondrial dysfunction, in a sense, it's a false starvation situation for the cell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this wcell — there are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mitochondria behave as if there's not enough oxygen,» says Chen, who with Birsoy, authored a paper in the journal Cell Reports describing this wCell Reports describing this work.

«Even when they had defective mitochondria, the cells with the retrograde response and AMPK simultaneously activated during growth were able to live as long as cells with normal mitochondrial function.»

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

In the absence of pain, morphine interferes with normal body function and is viewed as a pathogen, activating the brain's innate immune cells and causing the release of inflammatory chemicals such as cytokines.

To see if her recipe worked, she ran a test, applying a drug that should cause spheres made of normal, functioning cells to fill with fluid.

When the researchers pretreated the heart cells with a derivative of the sedative drug benzodiazepine before subjecting them to conditions that mimic a heart attack, the cells» mitochondria managed to regain normal function quickly, in effect restoring a steady supply of energy that prevented the cells from misfiring.

Proteins control essentially all biological processes in a cell, and while they may sometimes act alone, proteins most often interact with other proteins to carry out their normal biological functions.

A normal cell has chemical receptors on its surface that link up with specific molecules generated by the body and control the timing of such functions as eating and sleeping.

Senescence is associated with normal aging, and senescent cells accumulate in aged tissues, which impair the normal functions of the tissue and contribute to age - related diseases.

These reactions take place without interfering with the cells» ordinary functions, allowing them to speak the binary language of computers while continuing to work as normal cells.

«Our study sounds a serious warning about the possible detrimental side effects of this strategy, since we have shown that such antibodies cause dramatic degeneration of nerve cells by interfering with the normal on - off function of the prion protein,» he added.

«Any protein that interacts with PrP is likely to be interesting,» says cell biologist David Harris of Washington University in St. Louis, because it may be involved in both the protein's normal function as well as the disease - causing conversion.

«ECPR and a factor in the blood called protein C act as a «brake» on blood coagulation and endothelial cell inflammation and also enhance the viability and integrity of blood vessels, but when the malaria parasites use PfEMP1 to bind EPCR, they may interfere with the normal function of EPCR, and thus the binding can be the catalyst for the violent reaction,» he explains.

Ledley will transplant normal liver cells into a sick child with the aim of keeping the child alive until it is possible to find a donor for a conventional liver transplant, or to give the child's own liver function time to recover.

Electrophysiological recordings of these cells after culture for about 15 weeks revealed proper responses to currents and to inhibition of receptors needed for normal cerebellar signaling, indicating that function had developed along with structure.

Today, a team led by dos Santos, in collaboration with Professor Gregory Hannon of Cancer Research UK, Cambridge Institute, and Assistant Professor William Pomerantz at the University of Minnesota, identify a protein that they show must be present in order for mammary stem cells to perform their normal functions.

«More importantly, a retrovirus can infect only dividing cells such as reactive glial cells, but it does not affect neurons, which makes it ideal for therapeutic use with minimal side effect on normal brain functions.»

«Under normal circumstances, myofibroblasts stimulate wound healing, but when there's an ongoing injury to an organ (e.g., the liver of a hepatitis C patient, the heart of a patient with high blood pressure, or the kidney of a patient with diabetes) these proteins clog up normal functioning,» said Humphreys, a Harvard Medical School associate professor at Brigham and Women's Hospital, who leads the Harvard Stem Cell Institute Kidney Program.

Along with restoring structure and function to the p53 mutant protein, this drug compound has the ability to to activate a program that selectively kills cancer cells with this particular mutation while leaving normal cells undisturbed.

One theory is that this binding interferes with the RNAs» normal functions and impairs the overall health of cells.

Cre - DOG is also suitable for optogenetic studies, and since cells infected with AAV - Cre - DOG retain normal neuronal function, this system may make optogenetics in specific cell populations even easier.

Treating human apoE4 neurons with a structure corrector eliminated the signs of Alzheimer's disease, restored normal function to the cells, and improved cell survival.

Every normal tissue or organ comprises multiple resident cell types that are heterogeneous with respect to their morphologies, functions, and gene and protein expression patterns.

This program has provided the first comprehensive picture of how a gene normally associated with cancer can influence development, survival and normal function of brain cells central to age - associated neurodegenerative disorders such as Parkinson's disease.

Failure of satellite cell activation is also believed to cause skeletal muscle loss as these cells fuse with the muscle fibres and maintain their normal functioning.

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth

VLEDs are hypothesised to disrupt this flow of lipid between the liver and pancreas; within days of VLED commencement there is a rapid fall in IHCL and within weeks, reductions in pancreatic - fat can be detected with a corresponding return in normal Î ² - cell function.

In addition to their antioxidant properties, these polyphenolic compounds exhibit neuroprotective properties by their interaction with cellular signaling pathways followed by transcription and translation that mediate cell function under both normal and pathologic conditions.

What this means is that when the membrane is inflamed, the hormone can not communicate with the receptor and get its message into the cell where it needs to go for normal function.

In patients with normal kidney function, oliguria can indicate dehydration, and the small amount of urine produced will likely be concentrated (urine specific gravity [USG] > 1.030).5 Other laboratory parameters that change with dehydration include packed cell volume and total protein (PCV / TP) levels, which demonstrate hemoconcentration (high PCV) and hyperproteinemia (high TP) in dehydrated patients5 due to the loss of the fluid portion of the blood as the body tries to maintain fluid balance and homeostasis.

Lab Technician II — TRL Plasma Laboratories — January 2013 — Present • Monitor the heat sealing and aseptic sampling of plasma units; place units of plasma into freezer in timely manner in order to ensure quality of product • Label plasma samples and units properly and store according to policy; manage an average of 50 different plasma units on a regular basis • Evaluate refrigerator and freezer temperatures ad inform supervisor if equipment is malfunctioning • Maintain efficient and clean work environment and ensure inventory is stocked properly; answer phones and answer questions or transfer calls to appropriate departmentLab Technician I — ABC Medical Technologies, Inc. — May 2007 — January 2013 • Operated laboratory equipment, such as cell counters and microscopes, to analyze urine, blood, and tissue samples; recorded both normal and abnormal findings; had less than a.1 percent margin of error in sample findings • Used computerized instruments and automated equipment to perform multiple tests at one time; maintained calibration and proper function of equipment on a regular basis • Entered data from tests into physician reports; discussed abnormal results with supervisor and re-ran tests before logging data into patient's medical record