Sentences with phrase «with normal cells»

The main issue with intestinal parasites is that they compete with normal cells in the absorption of nutrients found in the food of your dog.

Apoptosis is the programmed activity of a cell's self destruction or suicide, which is common with normal cells to make way for new replacement cells.

Student Georgi Yordanov looks to study how cancer cells communicate with the normal cells surrounding them in a tumor...

The causes of the widespread differential expression of non-coding RNAs in malignant compared with normal cells can be explained by the location of these genes in cancer - associated genomic regions, by epigenetic mechanisms and by alterations in the processing machinery.

Stimulation of TRAIL protein is sustained in both tumor and normal cells, with the normal cells contributing to the TIC10 - induced cancer cell death through a bystander effect.

They coat the pad with a layer of anti-epithelial cell adhesion molecules (anti-EpCAM) which bond with CTCs but not with normal cells.

Dr Sophie Roerink, joint first author from the Wellcome Sanger Institute, said: «We found mutational processes in these cancer cells that are just not seen in normal cells, leading to a huge increase in mutation rate for tumours compared with normal cells.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

Cancer cells are unlike any other cell in the body and they act totally out of line with normal cell functions.

Not exact matches

After the woman's eggs have been retrieved through the normal IVF protocol and are ready for fertilization, the mitochondria taken from her stem cells are injected into an egg along with a sperm cell.

The researchers discovered that women with elevated NK cells were potentially more likely to miscarry a chromosomally normal baby in their next pregnancy.

Other kinds of congenital anomalies that are sometimes found with this condition are, as previously mentioned, Down Syndrome, shorter intestines than normal, lower birth weight, and an imbalance of electrolytes, which are the elements in the blood, tissue and cell fluid needed to help the person balance their energy.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

With microRNA - 210 in check, cells regain their normal function and cancer can not grow.

Carcinogens may cause cancer by altering cellular metabolism or damaging DNA directly in cells, which interferes with normal biological processes.

Asexual whiptails have a special trick for making spermless reproduction work: The egg cells in other animals first double their choromosomes once and then divide twice, leaving them as haploid cells, with half the normal number of genetic material.

But the whiptails» egg cells first double their chromosomes twice and then divide twice, leaving them with the normal number of chromosomes and rendering a sperm cell unnecessary.

People with normal color vision are known as trichromats because they possess these three kinds of photosensitive cone cells.

Finally, it could be shown that low regulatory T - cell numbers in umbilical cord blood was an indication that children exposed to tobacco smoke were more likely to develop an allergy before the age of three compared to those children with normal values for miR - 223 and Treg cells.

When she compared the «healer» cells from the lupus mice with «nonhealer» cells from normal mice, she noticed several differences.

Perhaps because it is normal for human embryos to contain cells with the wrong number of chromosomes, which can cause them to self - destruct.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

The team used viruses to replace the defective genes that cause the anaemia with normal ones, then used a second virus to insert genes that «reset» the cells to a pluripotent state.

The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.

Flies with hyperactive Rac seemed to forget the association faster than normal, and those with low activity seemed to remember longer — even when odours were introduced that should have distracted the flies or conflicted with their memories (Cell, DOI: 10.1016 / j.cell.2009.12.044).

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

In this latest advance reported in PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and disease.

DIPGs are known as one of the most challenging tumors to treat because cancer cells are intimately intermingled with normal brain cells in a part of the brain that can not be surgically resected.

HIV exploits the normal version of this protein to enter cells, but can not do the same with the mutated protein.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.

«This is the first demonstration that cells carrying a genetic disease are capable of spreading into the normal mammalian brain and lead to the manifestation of behavioral abnormalities associated with the disease,» says Francesca Cicchetti, professor at the Université Laval Faculty of Medecine and researcher at Centre de recherche du CHU de Québec - Université Laval.

To understand that process, the Florida State group engineered a fruit fly to produce a mix of cells, some with normal Lgl and some with the altered version.

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

The team found that yeast cells dosed with the deuterium - based fatty acids were up to 150 times as resistant to oxidative stress as cells treated with normal fatty acids (Free Radical Biology and Medicine, DOI: 10.1016 / j.freeradbiomed.2010.10.690).

These relatively normal tissue cells communicate with the cancer cells and play a major role in cancer progression, and could offer a new target for treatment.

These cells, named cancer stem - like cells, share many characteristics with the body's normal stem cells.

But when the mutant mice were injected with about 200,000 stem cells directly into their hippocampi and retested up to three months later, the injured animals performed up to par with their normal counterparts.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Work on animals has suggested that ultrasounds can in fact interfere with fetal brain development, derailing the normal movements of cells that populate the brain.

AT2101 is a first - generation «pharmacological chaperone» — a drug that can bind malfunctioning, mutated enzymes and lead them through the cell to their normal location, which allows the enzymes to carry on with their normal work.

With this glaucoma type, cells that normally secrete proteins inexplicably start to secrete more and the proteins cluster, forming structures that are too big to pass through the eye's normal fluid outflow pathway.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells.

Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

According to Eckmann, «The special thing about these processes is that they involve known molecules with very long evolutionary histories, previously receiving attention as suppressors of tumour formation within the context of normal cell division.

Moreover, the team compared TiY with a known vimentin - inhibitor, withaferin A (WFA) and observed that TiY has a stronger selectivity towards TICs than WFA, when compared with toxicity to normal cells and non-TIC cells.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

Compared with a normal mouse cochlea (top), cisplatin exposure reduces the number of outer hair cells (middle).