Sentences with phrase «with normal copies»

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

Researchers used a technique called CRISPR / Cas9 - mediated genome editing, which can precisely remove a mutation in DNA, allowing the body's DNA repair mechanisms to replace it with a normal copy of the gene.

But fish with a normal copy of the gene can't cope when researchers artificially block protein production from the same gene.

However, among the two - thirds with a normal copy of KRAS, regular use of such drugs was linked to a 40 percent increase in five - year survival.

In their analysis, the research team found that a process called compensatory uniparental disomy (UPD) was responsible for the complete replacement of the ring chromosome with a normal copy of chromosome 17.

Not exact matches

playing with g - rod up front is like sticking to fingers up to traditional arsenal play of fast movement one twos and pass and move football this is very unlike wenger to make such a major shift away front his normal trends of style of play big man up front with no pace just isn't the wenger way really he needs to go back to the past really to answer the current problem i have noticed all the other top 4 teams are more wenger they are (wengerites to coin a phrase) than wenger himself playing with a big srtong pacey team like we use to have they all copied wengers blueprint and left him behind somewhere along the line and he altered his and its not been the same since do nt change a winning system of power and pace if it is was working for you mr wenger

The scientists are also experimenting with gene therapy, using a harmless virus to deliver a normal copy of the normal CIB2 gene to baby mice that have the mutated version.

The findings jibe with previous reports that PCR tests sometimes overlook a gene with large deletions, detecting only the other, normal copy of the gene.

In contrast, only 7 % to 15 % of newborns with mutated versions of either gene — or normal copies of both — were afflicted.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

Cress with two mutant copies of one gene seem to be able to correct the DNA they pass on, ensuring that at least a few of their offspring revert to normal.

Cognitive neuroscientist Frederique Liegeois of University College London is using fMRI scans to compare the brain activity of members of the KE family who have a mutated copy of FOXP2 with those who have a normal version.

They frequently find that in both types of disease the region of the «healthy» copy of chromosome 17 that should carry the normal copy of the BRCA1 gene is missing, leaving only one copy of the gene — the one with the cancer - causing mutation.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

The team found that people with only one good copy of the gene make roughly half the normal levels of the hormone.

Apparently as a result, the 13 people they studied end up heavier and packed with a significantly higher percentage of body fat than family members with two normal copies of the leptin gene, the team reports in the 1 November issue of Nature.

While normal HD genes include up to 40 copies of the DNA sequence CAG, the mutated version is crammed with many more copies.

During maturation, her eggs all started out with four copies of the gene: two normal and two flawed.

First author Baoshan Xu, Ph.D., a former postdoctoral research associate in the Gerton Lab now starting his own lab at Sun Yat - sen University in China, worked with Hua Li, Ph.D., to use computational methods to count the number of copies of ribosomal DNA in normal and cancer cells of 162 patients from the eight projects.

Again, they found reduced survival: Over 10 years, 46 % of women with two copies of NQO1 * 2 survived, compared with 75 % of women with at least one normal NQO1 gene.

... When dopaminergic input comes in, [individuals with the SNPs on one gene copy] would have a chance of having more transmission» than those with two normal copies of the gene.

The scientists looked at a process known as meiosis, which unlike normal cell division (mitosis) has two rounds of nuclear division, to ensure that when sex cells fuse with each other, they have two copies of each chromosome — one from each parent!

The team eliminated three of the four known starch synthases by inserting backward copies of the genes for each one into the potato genome, which, through an unknown mechanism, interferes with the translation of the nearby normal gene.

The reason has been a mystery, but some researchers suspect it has to do with one or more of the genes on chromosome 21, which people with Down syndrome have three copies of instead of the normal two.

«Because individuals carrying a single mutant copy of a gene often mate with an individual with two normal copies of gene, defects can be hidden for a generation and then show up in the grandchildren,» Bier adds.

Thus, chronically increased p53 activity causes premature aging in mice, whereas transgenic mice with extra copies of p53 and ARF genes under normal regulation show tumor resistance and extended life span.

In tumor samples, where we frequently encounter variants with a very small allele frequency due to contamination with normal tissue, copy number variation, and tumor heterogeneity, high coverage is essential for accurate detection of these variants with high power.

Researchers used a lentivirus to infuse a normal copy of the ABCD1 gene into the bone marrow of boys with cerebral adrenoleukodystrophy (ALD), and the corrected protein stopped disease progression.

What we've found is that in addition to utilising online dating (if you haven't got a copy of Gary Gunn's best selling online dating book you can grab a copy here) and approaching and interacting with women during our normal daily activities (which you can find out more about on our live training page), speed dating should also make up a part of our global dating strategy.

Did something similar with Year 11 (to self assess ahead of preparing for Controlled Ass) and thought about making a presentation whose slides could be copied into a normal lesson presentation if doing peer / self assessment.

Give users the option of the normal book for the usual price, but a copy with ads included for 50 % off.

Dogs with two normal copies of the gene will not develop this type of cataract.

All Italian Greyhounds that were homozygous for the IG - PRA1 risk allele were diagnosed with PRA and two copies of the risk allele were never observed in any Italian Greyhounds with normal eye exams (at the risk age or older).

A dog with two copies of the normal CEA / CH gene is homozygous normal.)

NORMAL - the dog has two copies of the RSPO2 gene with the insertion and it has a coat with proper furnishings and wire hair which is the normal phenotype for the NORMAL - the dog has two copies of the RSPO2 gene with the insertion and it has a coat with proper furnishings and wire hair which is the normal phenotype for the normal phenotype for the breed.

Normal kidneys reabsorb the Amino Acid cystine so that only small amounts pass into the urine, while dogs with mutations of both copies of the SLC3A1 gene fail to reabsorb cystine allowing large amounts to pass into the urine, hence the name cystinuria.

Dogs with two copies of the mutation have CEA, those with one are normal carriers and those with none are clear.

Dogs without any copies of the diseased gene or carriers with one copy of the PDP1 deficiency form of the gene will be clinically normal but the carrier will pass the affected gene to approximately half the offspring.

Dogs affected with Type I vWD have a mutation which allows normal vWF to be produced part of the time, so even dogs with two copies of the defective gene (affected dogs) have some minimal amount of normal vWF.

CARRIERS - heterozygotes with one copy of the mutation and one copy of the normal gene do not develop NAD but they can transmit the PLA2G6 mutation to progeny.

The affected dogs (A) are homozygous for the dodecamer repeat expansion mutation with multiple dodecamer repeats, carrier (C) dogs have the normal and mutated allele and clear dogs (WT) have three copies of the repeat [8]

NORMAL / CLEAR - homozygotes with two normal copies of the gene do not develop NAD and can only transmit the normal gene to its offsNORMAL / CLEAR - homozygotes with two normal copies of the gene do not develop NAD and can only transmit the normal gene to its offsnormal copies of the gene do not develop NAD and can only transmit the normal gene to its offsnormal gene to its offspring.

The only Metroids she came into contact with were the Infant and its copies, and if the Infant is supposed to just be a baby Metroid Queen, then why is it that all of the other clones of it (which share the same DNA) are normal Metroids?

This is if the copy works, it does on my Ps4 which is a few years old (not sure how to describe it, normal edition with a smooth power button), but my friends is a little older possibly an original version (the power and disk buttons jut out a bit) and this game simply doesn't work on his.

This new tier is included in higher tiers as normal and has been established to automatically provide the $ 100 tier with a physical copy of the game.

You must file a formal claim with the transportation provider and provide Us with copies of all claim forms and proof that the transportation provider has paid you its normal reimbursement for the lost, stolen or damaged luggage.

You can click the drive and copy files back and forth like you would with a normal external drive.

[i] They also have the right to inspect the child care setting without advance notice during normal operating hours while the child is present (unless, as noted in the previous answer, the custodial parent has given you a written request to prevent such visits along with a copy of the court order that supports that request).