Sentences with phrase «with normal gene»

This was attributed to «recombination» taking place between the marker and the actual gene during the formation of gametes (sperm and eggs), resulting in the marker normally associated with the mutant gene and that associated with the normal gene being «switched over».

That means I need to find ways to increase BDNF more than in someone with the normal gene in order to preserve my cognitive function, memory, and emotional regulation.8 Mu, J.S., et al. «Deprivation of Endogenous Brain - Derived Neurotrophic Factor Results in Impairment of Spatial Learning and Memory in Adult... continue 9Cirulli, F., et al. «Intrahippocampal Administration of BDNF in Adult Rats Affects Short - term Behavioral Plasticity in the Morris Water Maze and... continue

«A totally normal - looking worm with a normal gene expression and stem cell distribution can in fact be harbouring a [body plan] that's quite different,» says Levin.

The cells with the normal gene grew significantly longer dendrites — the portions of the cell that reach out to receive nerve impulses — than did neurons with the mutated gene, the team reports 14 October in Science.

f. Quantifying the long lived proteins, fats, sugars, etc that increase with aging by comparing 1 years old rats to 2 year old rats tissue, taking the difference and seeing which can be processed with normal genes being re-regulation and which we can not degrade.

Not exact matches

Guys who are rated as the most masculine — a billboard for a man's good genes — tend to have more testosterone, and men with higher testosterone levels are 43 percent more likely to get divorced than men with normal levels, 31 percent more likely to split because of marital problems and 38 percent more likely to cheat.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

The scientists are also experimenting with gene therapy, using a harmless virus to deliver a normal copy of the normal CIB2 gene to baby mice that have the mutated version.

But they do seem to have some interest in the opposite gender: Sometimes these parthenogens are mate with males of different species, creating a species with 50 percent more genes than normal.

When normal and gene - altered mice got the high - fat diet along with varying levels of doxycycline, to induce GLP1 release, the normal mice grew fat and mice expressing GLP1 showed less weight gain.

When normal and gene - altered mice ate the high - fat diet — along with varying levels of doxycycline to induce GLP1 release — mice expressing GLP1 (left) gained less weight gain while normal mice (right) grew fat.

The team used viruses to replace the defective genes that cause the anaemia with normal ones, then used a second virus to insert genes that «reset» the cells to a pluripotent state.

The findings jibe with previous reports that PCR tests sometimes overlook a gene with large deletions, detecting only the other, normal copy of the gene.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

The researchers ran physiological tests on 43 people with one mutated gene and compared them with others in the community with two normal versions.

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

When an altered X chromosome is passed down to female offspring, Gantz reasoned, the gene drive should convert the normal X from the other parent into one with a broken yellow gene.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

Fragile X occurs when a segment in the FMR1 gene on the X chromosome called the CGG triplet repeat is lengthened from the normal 5 to 40 repeats to 200 repeats in people with full mutation FXS.

Tissue taken from mice with the C. elegans gene had significantly higher levels of omega - 3 acids compared with that of normal animals, the team found.

In contrast, only 7 % to 15 % of newborns with mutated versions of either gene — or normal copies of both — were afflicted.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

The organoids with the mutated gene grew to the same proportions as the first group, but they developed few folds and the ones they did develop were very different in shape from normal wrinkles.

They destroyed the T cells in 12 mice, five of which received marrow cells from normal mice while seven received marrow from mice with a defective Fas - ligand gene.

Mineral deposits and bone formation around toe joints of mouse with mutation in the ank gene (mutant foot shown on right, normal skeleton on left).

Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests.

Cress with two mutant copies of one gene seem to be able to correct the DNA they pass on, ensuring that at least a few of their offspring revert to normal.

«But fruit flies have all their histone genes in one place on the chromosome; this makes it feasible to delete the normal genes and replace them with designer genes.»

The drug killed mutated strains with those genes knocked out faster than it killed the normal strain (solid lines), even though the three strains grew similarly without the drug (dashed lines).

Within a single tumor exists such an astonishingly varied population of cells, each with its own combination of normal and abnormal genes, that at least some cells nearly always have a way to survive any particular attack.

«We were surprised that the heritability of depressive symptoms in twins with very short sleep was nearly twice the heritability in twins sleeping normal amounts of time,» said principal investigator Dr. Nathaniel Watson, associate professor of neurology and co-director of the University of Washington Medicine Sleep Center in Seattle, Wash. «Both short and excessively long sleep durations appear to activate genes related to depressive symptoms,» added Watson, who also serves on the board of directors of the American Academy of Sleep Medicine.

Prof. Hasan's work used Drosophila flies with mutated Orai genes that prevented normal operation of the SOCE process.

Researchers used a technique called CRISPR / Cas9 - mediated genome editing, which can precisely remove a mutation in DNA, allowing the body's DNA repair mechanisms to replace it with a normal copy of the gene.

When the researchers then induced stroke in mice either with or without the PARP gene, they found that the resulting tissue damage in the mice without the enzyme was 80 % less than in normal mice.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

They frequently find that in both types of disease the region of the «healthy» copy of chromosome 17 that should carry the normal copy of the BRCA1 gene is missing, leaving only one copy of the gene — the one with the cancer - causing mutation.

Ornish, who has built a reputation on advocating healthy living, and U.C.S.F. colleagues report in the journal Proceedings of the National Academy of Sciences USA that they found the activity of more than 500 genes in the normal tissue of 30 men with low - risk prostate cancer changed after the patients began exercising regularly and eating diets heavy in fruit, veggies and whole grain (supplemented with soy, fish oil, the mineral selenium and vitamins C and E) and low in red meat and fats.

Their research, published in PLOS ONE, focused on one particular gene — TRIM29 — selected from a pool of 100 genes with regulatory patterns specific to normal breast tissue, to prove the link between breast - specific genes and the pathology of cancer.

When the researchers treated mice with JQ1, many of the abnormal activity levels of Brd4 target genes returned to normal.

«In order to be able to research more closely what effect PSENEN has, we, in collaboration with Prof. Odermatt, deactivated the gene in some zebrafish larvae and then compared these with normal larvae under the microscope,» explains Damian Ralser.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

Similarly, someone who inherits the version of a particular gene that's associated with obesity will be more likely to wind up fat than someone who inherits a normal version, but that tendency can be affected by environmental factors such as how much fattening food is available.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

The reason, reported in today's Science, is that fruit flies with a mutated methuselah gene live up to 35 % longer than normal fruit flies.

Comparing the damaged sites in normal cells before and after infection with H. pylori revealed that genes located close to the margins of the chromosomes, the so - called sub-telomeric regions, are more likely to be damaged after infection, as are genes that are active in gastric cells.

Longo also knew of research by molecular biologist John Kopchick at Ohio University, which showed that mice with a mutation in their growth hormone receptor gene lived 40 percent longer than normal mice — the equivalent of an average American living to age 110.

The team found that people with only one good copy of the gene make roughly half the normal levels of the hormone.

Apparently as a result, the 13 people they studied end up heavier and packed with a significantly higher percentage of body fat than family members with two normal copies of the leptin gene, the team reports in the 1 November issue of Nature.

While normal HD genes include up to 40 copies of the DNA sequence CAG, the mutated version is crammed with many more copies.