Cells
with normal karyotype were injected into blastocysts isolated from C57BL / 6 mice.
Among cases with sonogram anomalies, microarrays detected genetic problems in 6 % of
those with a normal karyotype.
Microarray analysis, the researchers found, revealed genetic conditions in 2.5 % of the pregnancies
with a normal karyotype.
FLT3 mutations are more common in patients
with normal karyotype and appear to be associated with a higher rate of relapse after conventional chemotherapy.